2-y-e1-1 yia recombinant human α δ-1 purification for ......recombinant human α2δ-1 purification...

2-Y-E1-1

Recombinant human α2δ-1 purification for structural analysis of mirogabalinbinding mode

Daisuke Kozai1,2, Nobutaka Numoto3, Kouki Nishikawa4, Akiko Kamegawa4,5, Hiroyuki Hanzawa6,Kousei Shimada7, Mizuki Takahashi6, Yutaka Kitano7, Yoshinori Fujiyoshi4,5

1CeSPI, Nagoya Univ., 2JBIC, 3Med. Res. Inst., Tokyo Med. and Dent. Univ.,4CeSPIA Inc., 5Adv. Res. Inst., TokyoMed. and Dent. Univ., 6Daiichi-Sankyo RD Novare Co., Ltd., 7Daiichi-Sankyo Co., Ltd.

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Copyright © The Japanese Pharmacological Society

2-Y-E1-2

V1a Vasopressin Receptor Deficient Mice as a Model for Accelerated Aging

Casmad Fujianti, Morio Azuma, Sajjaviriya Chortip, Hiroyoshi Tsuchiya, Taka-aki Koshimizu

Juchi Med. Univ. Mol. Pharmacol.

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2-Y-E1-3

1,2-Naphthoquinone functions as an activator of the EGF receptor viacovalent modification of a specific lysine residue

Kengo Nakahara1, Tomoki Tsuchida1, Yumi Abiko2, Yoshito Kumagai2, Takashi Uehara1

1Department of Medical pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences,Okayama University, 2Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba

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2-Y-E1-4

EGFP-tagged Syntaxin 17 localized on autophagosome is accumulated byDoxorubicin

Guanjie Li1, Delan Lin1, Noriko Toda1,2, Masaki Saito1, Masanori Yamauchi2, Kazuhiko Yanai1,3,Takeya Sato1

1Dept. Mol. Pharmacol., Tohoku Univ., Grad. Sch. Med,2Dept. Anes & Perio Med., Tohoku Univ., Grad. Sch. Med,3Dept. Pharmacol., Tohoku Univ., Grad. Sch. Med

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2-Y-E2-1

Transcription factor ATF4 maintains pancreatic β-cell identity during ERstress

Keisuke Kitakaze1,2, Miho Oyadomari1, Jun Zhang1, Yoshimasa Hamada1, Yasuhiro Takenouchi2,Kazuhito Tsuboi2, Yoshio Fujitani3, Yasuo Okamoto2, Seiichi Oyadomari1

1Div. of Mol. Biol., Inst. for Genome Res., Inst. of Adv. Med. Sci., Tokushima Univ.,2Dept. of Pharmacol., KawasakiMed. Sch., 3Lab. of Dev. Biol. and Metab. Inst. for Mol. and Cell. Regul., Gunma Univ.

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2-Y-E2-2

Role of alpha 1 antitrypsin-induced ER stress in placental trophoblast cells

Kanoko Yoshida1, Kazuya Kusama1, Kiyoko Kato2, Gen Ishikawa3, Mikihiro Yoshie1,Kazuhiro Tamura1

1Dept. Pharmacol., Tokyo Univ. Pharm. & Life Sci.,2Dept. Obstet. & Gynecol., Kyushu Univ., 3Dept. Obstet. &Gynecol., Nippon Med. Sch.

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2-Y-E2-3

Globin Digest Exerts Anti-Obesity Effects through UCP1 Upregulation inZebrafish and Mouse Obesity Models

Zang Liqing1, Yasuhito Shimada2, Hiroko Nakayama1, Izumi Matsuoka1, Youngil Kim3, Djong-Chi Chu3, Lekh Raj Juneja3, Rika Tsuruta4, Yuka Sasakawa4, Junya Kuroyanagi5,Norihiro Nishimura1

1Grad. Sch. of Regional Innovation Studies, Mie Univ., 2Dept. Integr. Pharmacol., 3Rohto Pharmaceut. Co., Ltd.,4MG Pharma Inc., 5UMOU Sci. Lab

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2-Y-E2-4

Comprehensive cardiotoxicity assessment of hydroxychloroquine usinghuman iPSC-derived cardiomyocytes

Yanagida Shota1,2, Ayano Satsuka1, Sayo Hayashi1, Atsushi Ono2, Yasunari Kanda1

1Div. Pharmacol, NIHS, 2Div. Pharmaceut. Sci, Grad Sch Med., Dent. and Pharmacet. Sci, Okayama Univ.

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2-Y-E3-1

Chemerin/CMKLR1 in the brain of spontaneously hypertensive rats mediatessystemic hypertension

Atsunori Yamamoto1, Naoko Yamaguchi2, Shoshiro Okada2, Kosuke Otani1, Muneyoshi Okada1,Hideyuki Yamawaki1

1Lab. Vet Pharmacol., Sch., Vet. Med., Kitasato Univ.,2Dept. Pharmacol., Sch., Med., Aichi Med. Univ.

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2-Y-E3-2

The alteration of molecular properties in plasma extracellular vesicles fromspontaneously hypertensive rats

Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University

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2-Y-E3-3

Evaluation of the pathological symptoms in retinal vascular disease withneovascular glaucoma

Anri Nishinaka, Miruto Tanaka, Koki Nitta, Shinsuke Nakamura, Masamitsu Shimazawa,Hideaki Hara

Gifu Pharmaceut . Univ.

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2-Y-E3-4

The role of ANKFY1 in endothelial cells for retinal angiogenesis

Miruto Tanaka1, Shinsuke Nakamura1, Masashi Maekawa2,3, Shigeki Higashiyama2,3,Hideaki Hara1

1Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 2Division ofCell Growth and Tumor Regulation, Proteo-Science Center, Ehime University,3Department of Biochemistry andMolecular Genetics, Ehime University Graduate School of Medicine

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2-Y-F1-1

Inhibitory effect of panaxytriol on the lipopolysaccharide-induced microglialactivation

Genki Hiramatsu1, Kosuke Matsuda1, Daisuke Uta1, Kenichi Mihara2, Ysuhunobu Andoh4,Toshiaki Kume1

1Dept. Appl Pharmcol. Toyama Univ.,2Dept. Appl Pharmcol. Toyama Univ.,3KIM's Korean Ginseng Co. Ltd., 4Dept.Pharmacol & Pathophysiol. Kinjo Gakuin Univ.

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2-Y-F1-2

Real-time imaging unveils mechanisms underlying synaptic engulfment bymicroglia

Megumi Andoh1, Yuji Ikegaya1,2,3, Ryuta Koyama1,4

1Lab. of Chem. Pharmacol., Grad. Sch. of Pharmaceut. Sci., The Univ. of Tokyo,2Inst. for AI and Beyond, 3Centerfor Information and Neural Networks, 4Japan Sci. and Tech. Agency, PRESTO

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2-Y-F1-3

Identification of scavenger inducing factor for the accelerated removal ofinflammatogenic DAMPs

Otani Kento1,2, Jun Tsuyama1, Koji Hase2, Takashi Shichita1

1Stroke Renaissance Project, Tokyo Met. Inst. of Med. Sci.,2Dept. Biochem., Grad. Sch. of Pharmaceutical Sci.,Keio Univ.

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2-Y-F1-4

A subpopulation of microglia emerged in a recovery phase of neuropathicpain

Kohno Keita, Makoto Tsuda

Dept. Mol. and Syst. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ.

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2-Y-F2-1

Intrathecal injection of sulfatides induced mechanical allodynia via glial cellsactivation and nitric oxide production

Motoki Morita1,2, Shun Watanabe1,2, Misa Oyama1,2, Takashi Iwai1,2, Mitsuo Tanabe1,2

1Lab. Pharm., Sch. Pharm., Kitasato Univ., 2Medical Research Lab.,Sch. Pharm.,Kitasato Univ.

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2-Y-F2-2

Treatment with anti-interleukin-6 receptor antibody improves mechanicalhypersensitivity and cognitive dysfunction in mice with neuropathic pain

Kodai Moriwaki1, Kazue Nakashima2, Toshiki Yoshii1, Yoki Nakamura2, Norimitsu Morioka2

1Dept. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., 2Sch. Pharmaceu. Sci., Hiroshima Univ.

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2-Y-F2-3

Comprehensive analysis of epigenetic modification under a persistentpostoperative pain-like state

Tanaka Kenichi1,3, Yoshiyuki Yamabe1,3, Michiko Narita2,3, Hideyuki Takesima4,Yusuke Hamada1,3, Daisuke Sato1,3, Yosuke Katsuda1,5, Masako Iseki5, Takahiro Ochiya2,Naoko Kuzumaki1, Toshikazu Ushijima4, Minoru Narita1,3,5

1Dept. Pharmacol., Hoshi Univ., Tokyo, Japan,2Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan,3Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan,4Div. Epigenomics, Natl. Cancer Ctr. Res. Inst.,Tokyo, Japan, 5Dept. Anesthesiol., Pain Med., Juntendo Univ., Tokyo, Japan

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2-Y-F2-4

Inhibitory effects of anti-high mobility group box-1 neutralizing antibody onnociceptive hypersensitivity in Parkinson’s disease

Fumiaki Sato1, Yoki Nakamura2, Simeng Ma2, Takahiro Kochi2,3, Kazue Hisaoka-Nakashima2,Wang Dengli4, Keyue Liu4, Hidenori Wake4, Masahiro Nishibori4, Norimitsu Morioka2

1Sch. Pharmaceu. Sci., Hiroshima Univ., 2Dept. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ.,3Dept. Dent. Anesth., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., 4Dept. Pharmacol., Grad. Sch. Med.,Dentistry & Pharmaceu. Sci., Okayama Univ.

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2-Y-F3-1

An essential role of the median raphe serotonin neurons projecting to theinterpeduncular nucleus in reward processing.

Kawai Hiroyuki1, Yuma Nagai1, Masashi Koda1, Naoya Nishitani2, Kazuki Nagayasu1,Hisashi Shirakawa1, Shuji Kaneko1

1Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 2Lab. Mol. Pharmacol., Inst. Med.,Pharmaceut., Health Sci., Kanazawa Univ.

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2-Y-F3-2

Distinct role of heterogeneously expressed receptors on D2-receptor-containing medium spiny neurons in the development of behavioralsensitization induced by abused drugs

Kensuke Yamashita1, Kotaro Oikawa1, Yusuke Hamada1,2, Daisuke Sato1, Michiko Narita2,3,Naoko Kuzumaki1, Tomohisa Mori1, Minoru Narita1,2

1Dept. Pharmacol., Hoshi Univ., Tokyo, Japan,2Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan,3Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan

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2-Y-F3-3

Piccolo knockdown in the nucleus accumbens suppressedmethamphetamine-induced alterations

Yuka Kusui1, Kyosuke Uno1,2, Shin-ichi Muramatsu3,4, Atsumi Nitta1

1Dept. Pharm Therap and NeuroPharm, 2Dept. Funct Molphology, 3Univ. Jichiika, 4Univ. Tokyo Ctr. Therap gene

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2-Y-F3-4

Oxytocin reverses 3,4-Methylenedioxypyrovalerone-induced impairment ofhippocampal synaptic plasticity in mice

Takahshi Junpei1, Daisuke Yamada1, Kosho Makino2, Ryo Fujikawa1, Toshinori Yoshioka1,Eri Koga1, Hideyo Takahashi2, Akiyoshi Saitoh1

1Lab Pharmacol., Fac Pham Sci, Tokyo Univ of Science, 2Lab Med Chem., Fac Pham Sci, Tokyo Univ of Science

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2-Y-G1-1

Chemogenetic inhibition of histaminergic neurons significantly decreasedwakefulness during the dark periods in mice.

Hiroshi Kuroyanagi, Masato Tanaka, Fumito Naganuma, Tadaho Nakamura, Nobuyuki Okamura

Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University

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2-Y-G1-2

Acute effect of ramelteon treatment on central and peripheral activity of ratsduring wakefulness and sleep

Airi Yoshimoto1,2, Kotaro Yamashiro2, Takeshi Suzuki1, Yuji Ikegaya2, Nobuyoshi Matsumoto2

1Keio Univ. Fac. Pharm., 2Grad. Sch. Pharmaceut. Sci., Univ. Tokyo

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2-Y-G1-3

The role of the formin protein Fhod3 in morphogenesis of dendritic spines inthe mouse cerebral cortex

Hikmawan Wahyu Sulistomo1,2, Takayuki Nemoto1,3, Yohko Kage1, Hajime Fujii4, Haruhiko Bito4,Ryu Takeya1

1Dept. of Pharmacol., Fac. of Med., Univ. of Miyazaki, 2Dept. of Pharmacol., Fac. of Med., Univ. of Brawijaya,3Dept. of Pharmacol., Fac. of Med., Fukuoka Univ., 4Dept of Neurochem., Grad. Sch. of Med., The Univ. of Tokyo

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2-Y-G1-4

Proliferative effect of tri-deoxyribonucleotides on mouse neural stem cells

Takahiro Ishimoto1, Naoto Matsumura1, Yusuke Masuo1, Keisuke Kiriyama2, Keita Sutoh2,Yukio Kato1

1Fac. Pharm., Kanazawa Univ., 2FORDAYS Co., Ltd.

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2-Y-G2-1

Muscle specific aging signature of PDGFRα-positive stromal cells underliesthe development of age-related sarcopenia

Kurosawa Tamaki1,2, Noriyuki Kaji3, Madoka Uezumi2, Heying Zhou2, Keitaro Minato2,Akiyoshi Uezumi2, Masatoshi Hori1

1Lab. of Veterinary Pharmacol., Dept. of Veterinary Med. Sci., Grad. Sch. of Agr. and Life Sci., Tokyo Univ.,2MuscleAging and Regenerative Med., Tokyo Metropolitan Inst., of Gerontol.,3Lab. of Veterinary Pharmacol., Sch. ofVeterinary Med., Azabu Univ.

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2-Y-G2-2

Treatment with resveratrol attenuates aging-related loss of muscle mass andfunction in mice.

Ryusuke Hosoda, Atsushi Kuno, Seidai Asakura, Naotoshi Iwahara, Iyori Nojima,Risa Kunimoto, Yoshiyuki Horio

Dept. Pharmacol., Sapporo Med. Univ. Sch. Med.

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2-Y-G2-3

Involvement of microRNA-133a-3p with the conversion of muscle fiber typein human skeletal myogenesis.

Zhou Yuhang1, Yoshinori Ichihara1, Hirotaka Iwasaki2, Agung Kurniawan Priyono1,Tatsuya Sawano1, Keiko Nagata1, Junichiro Miake1, Hidetoshi Sakurai3, Takeshi Imamura1

1Tottori University, Pharmacology Department, 2Shiga Medical Unicersity, Pharmacology Department, 3KyotoUniversity, iPS Cell Institute

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2-Y-G2-4

Pyro-drive jet injector (PJI) as a novel gene transfer approach to muscletissues

Takafumi Nakae1, Masanori Obana1,2, Takahiro Maeda1, Hiroshi Miyazaki3, Kazuhiro Terai3,Yasushi Fujio1,2

1Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical sciences, Osaka University,2Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary ResearchInitiatives (OTRI), Osaka University, 3Medical Device Division, Innovation and Business DevelopmentHeadquarters, Daicel Corporation

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2-Y-G3-1

Topical treatment of Mastic significantly ameliorates inflammatory andpruritic response in a mouse model of atopic dermatitis.

Kishimoto Risako1, Mayuka Koike1, Naoki Iwashita1,2, Tomoki Fukuyama1

1Lab.Veterinary pharmacology,Sch.Veterinary Medicine,Azabu Univ.,2Bioalchemis

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2-Y-G3-2

15d-Prostaglandin J2 inhibits noncanonical inflammasome response toameliorate endotoxin shock.

Manabu Taura, Ryosuke Sasaki, Naoki Takemura, Tatsuya Saitoh

Laboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University

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2-Y-G3-3

Bitter taste receptor signaling facilitates neutrophil migration

Daichi Kobayashi1, Atsumasa Tohda1, Madoka Ozawa1, Yasuhiro Kanda1, Arata Takeuchi1,Fumihiro Saika2, Norikazu Kiguchi2, Shinsuke Matsuzaki3, Tomoya Katakai1

1Niigata Univ. Med. Dent. Immunol., 2Wakayama Med. Univ. Med. Pharmacol.,3Morinomiya Univ. Med. Sci.Radiobiol.

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2-Y-G3-4

Clarification of pathophysiological roles that suppressed Th2 cytokineresponse by Aquaporin-5

Keisuke Osada, Kanta Fujikawa, Takumi Okaya, Yoichiro Isohama

Lab. appl. Pharmacol., Fac. of Pharm. Sci., Tokyo univ. of Sci

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2-Y-G3-5

Role of NKT cells in liver repair after hepatic ischemia-reperfusion injury inmice

Goto Takuya1,2,3, Yoshiya Ito1,2, Masashi Satoh4, Shuji Nakamoto1,2,3, Kanako Hosono1,2,Ko Hatanaka1,2, Hideki Amano1,2

1Dept. of Mol. Pharmacol., Kitasato Univ. Grad. Sch. of Med. Sci., 2Dept. of Pharmacol., Kitasato Univ. Sch. ofMed, 3Dept. of Surg., Kitasato Univ. Sch. of Med., 4Dept. of Immunol., Kitasato Univ. Sch. of Med

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2-y-e1-1 yia recombinant human α δ-1 purification for ......recombinant human α2δ-1 purification...

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