124 nitrate tolerance

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Nitrate Tolerance • Decreased biotransformation or activity of nitric oxide (NO) • Counterregulatory mechanisms including neurohormonal activation and plasma volume expansion • GTN increases MMP activity • Survival after MI is worst in pts treated with nitrates

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Page 1: 124 nitrate tolerance

Nitrate Tolerance• Decreased biotransformation or activity of

nitric oxide (NO)• Counterregulatory mechanisms including

neurohormonal activation and plasma volume expansion

• GTN increases MMP activity• Survival after MI is worst in pts treated

with nitrates

Page 2: 124 nitrate tolerance

Page 3: 124 nitrate tolerance

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124 nitrate tolerance

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