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Today’s Technology to Keep Access Sites Dry and

Intact

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The ChallengeA major source of catheter-related infection is soiled, wet or loose dressings caused by bleeding or oozing at insertion sites and/or diaphoresis.

The Centers for Disease Control (CDC) Guidelines for Prevention of Intravascular Catheter-Related Infections include recommendations to:

Replace catheter-site dressing if the dressing becomes damp, loosened, or visibly soiled; therefore, keep catheter site dry and intact.

Replace dressings used on short-term CVC sites every 2 days for gauze dressings and at least every 7 days for transparent dressings.

How do you keep access sites dry and intact?

Photos by Penny Offer, CRNI

Site without BioSeal CVC – soiled dressing

Site with BioSeal CVC –Dry/intact dressing 0-7days

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The Solution: BioSeal CVC Powder

The ingredients are a mixture of a hydrophilic polymer and a potassium ferrate.

BioSeal CVC Powder is not a vasoconstrictor, or a cauterizing agent. It is non-systemic, non-toxic and it is not biologically derived.

BioSeal CVC Powder, formerly PRO QR Powder, is a topical powder that forms an occlusive seal to stop the flow of blood and exudates and keep microbes from entering the site.

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Proven EfficacyResults from a product trial** of BioSeal CVC (PRO QR) usage for 418 PICC lines at a large Florida hospital:

Time to Hemostasis (including patients with clotting difficulties)

≤ 2 minutes in 96% of applications

Elimination of 24-48 hour dressing change (first dressing change at 7 days)

100%

Total reported complications 0

Reduction in Catheter-Related Bloodstream Infections (CRBSIs)

40%

**Trial results on file at Biolife.

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How Does the Powder Work? The mechanism of action is a simultaneous

two-step action whereby the hydrophilic polymer rapidly dehydrates the blood and absorbs exudates while the potassium ferrate binds with the blood proteins to create an occlusive seal.

As the blood becomes dehydrated, the “nothing in, nothing out” seal thickens until blood and nutrient-rich exudates can no longer permeate through the seal. The seal creates a hostile barrier to microbes on the distal side, while maintaining a neutral environment on the proximal side.

For more on the mechanism of action, see the video at: http://www.youtube.com/watch?v=00bcKWOFTrs

Actual scanning electron microscopy (SEM) image

BioSeal CVC Powder

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The Difference is the Seal

The seal:

Allows “nothing in/nothing out” Keeps sites dry and intact Minimizes complications from

bleeding/exudate leakage Eliminates unnecessary dressing

changes Fits all sizes of lines or tubes Increases patient satisfaction

SEM photography of a 5 Fr. Catheter. Note the occlusive seal that

has formed around the line.

Seal the site, don’t just patch it.TM

Extra powder

Seal

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BioSeal Creates a Sustained Hostile EnvironmentAbove the Seal

• Bacteria, full of water and salts, come in contact with the BioSeal CVC powder on the top side of the seal. (H20 & Ca++, Na+, K+)

• The bacteria dries (desiccation)• The moisture pulled from the bacteria contain salts.

The cations of these salts are exchanged for H+ (acidic), creating a low pH environment (~2) above the seal.

The Seal• Composed of coagulated blood components• Below the seal the pH is ~ neutral• Above the seal the pH is ~ 2

Below the SealThe BioSeal CVC Powder floats on the blood, therefore it doesn’t penetrate the seal. This results in a neutral pH below the seal. (The pH below the seal was measured @ 7.4 in a saline extraction of a laboratory-created seal.)

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Key ApplicationsUse BioSeal CVC Powder with the following devices to stop bleeding and oozing and protect the site:

Vascular Devices: (insertions and removal)

PICCs/Midlines Central Venous Catheters Dialysis Catheters Arterial Catheters (maintenance)

Also effective in controlling bleeding and exudate leakage from Non-Vascular Devices such as:

Peritoneal dialysis catheters Epidural catheters Large-bore needles used for paracentesis, thoracentesis, or biopsies PEG/Gastrostomy feeding tubes

Photo by Penny Offer, CRNI

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BioSeal CVC Application – Tips for SuccessDo’s: To ensure success, secure the line with securement

device before applying powder Apply firm pressure for two minutes directly over wound

with dry, gloved fingers or non-adherent dressing to form the protective seal and achieve hemostasis.

Roll fingers off of site to release pressure Leave seal over wound; the “BioSeal” will fall off naturally

on its own, or if needed, may be removed with sterile technique.

Don’ts: Do not hold pressure over BioSeal powder with gauze to

avoid tearing the seal (use dry, gloved fingers instead). Do not check for hemostasis before the recommended

holding time complete. This could disturb the strengthening seal.

Pour Powder

Hold Pressure

Seal is formed

Photos by Penny Offer, CRNI

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Additional Clinical Studies

Further clinical studies have been completed and data is available for the following BioSeal CVC Powder applications:

Vascular Access (arterial and venous) Mohs Surgery Wound dehiscence

Ask your sales representative for further information including clinical references.

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Educational Tools

Brochures for Patients and Medical Staff Posters Protocols Computer-based Learning Modules Other support at www.biosealcvc.com

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BIOSEAL CVC Ordering Information

Order Number Product Description

LP606 6 Applications per Box*

LP636 24 Applications per Case*

* Each application includes bottle, PCD, product description label and Patient Discharge Instructions.

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More Biolife Products

BioSeal Advanced Biolife’s powder technology

that controls external bleeding from arterial access procedures

PRO QR for Nosebleeds Topical powder that stops

anterior nosebleeds and other hard to reach wounds in a convenient package with an applicator

Other Biolife product offerings include:

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For More Information

Call Biolife at 800-722-7559 Visit www.biosealcvc.com