1 one-minute nmr history current events 17 august 2006 presented by tim peck & dean olson
TRANSCRIPT
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One-Minute NMR• History• Current Events
17 August 2006
Presented by Tim Peck &
Dean Olson
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e-Seminar Etiquette
Press *6 to mute
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(to ask a question)
As a courtesy to others, please mute your phone line while listening:
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One-Minute NMRhistorical roots
UIUC Campus
Paul Lauterbur: MRI
Herb Gutowski Memorial
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One-Minute NMR2006 tour
• Am. Soc. of Pharmacognosy: Arlington, VA 8/6 – 8/9• ENC: Monterey, CA 4/24 – 4/28
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MicroFlow NMRThe NMR Front End for the Modern Analytical Laboratory
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Live ParticipationEnter Your Sample Info
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System OperationWatch the Analysis!
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NMR Data Collected Pre-Conference Varian Inova 600 MHz
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View the Results!Automated Structure Confirmation
Click
…
Thumbs Up!(Confirmation)
Thumbs Down!(Rejection)
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View the Results!Automated Structure Confirmation
Integrated ACD/Web Librarian
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Am. Soc. PharmacognosyAugust 6-9, 2006
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Natural ProductsChemical Assignment Rapid Dereplication
M. Gronquist, J. Meinwald, F. C. Schroeder, JACS 2005, 127, pp. 10810-10811
dqf-COSY spectrum 8 scans 512 complex incrementstotal time 3 h 45 min
coupled non-gradient HMQC spectrum 16 scans, 512 complex incrementstotal time 7 h
non-gradient HMBC spectrum baseline-subtracted in F164 scans, 460 complex incrementstotal time 21 h 45 min
NOESY spectrum 16 scans, 256 complex incrementstotal time 4 h 18 min
dqf-COSY
HMQC
HMBC
NOESY
S. Van der Sar, J. Blunt, and M. Munro, Org. Let. 2006, 8(10), pp. 2059-2061
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Some time for fun…
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And re-connecting with old friends
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How Small is 10 μL?
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Autosampler Injection Port
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Autosampler Needle on a96-Well Microtitre Plate
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Needle at Wash Station
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Autosampler Control Pad
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Solvent Conditioner Bottles
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Solvent Conditioner
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One-Minute NMR Features
SampleReturn
SampleReturn
StackedSample
Drawers
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One-Minute NMRSystem Configuration
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Quiz Question: What is this?
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Hint:Am. Soc. Pharmacognosy Dinner Cruise was down the Potomac
river