1 nucleotides: the subunits of dna. 2 the four dna bases gc a t
TRANSCRIPT
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Nucleotides: the subunits of DNA
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The four DNA bases
G C
A T
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DNA strand: polymer of nucleotides
DNA Double Helix
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Examples of proteinsProtein Role
alpha-keratin component of hair
beta-keratin component of scales
insulin regulates blood glucose level
actin & myosin muscle contraction
DNA polymerase synthesis of DNA
ATP synthase makes ATP
hemoglobin transport of oxygen
endonuclease cuts DNA (restriction enzyme)
EcoRI – restriction enzyme
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Hemoglobin: carrier of oxygen
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Mutant -globin Sickle blood cells
Fiber of sickle hemoglobin Sickle and normal blood cells
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Normal blood flow
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Sickle cell complications
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The alphabet of protein: 20 amino acids
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Protein: polymer of amino acids
Nucleotides vs. Amino Acids
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Nucleotide Amino Acid
Both made up of “backbone” and “residue” parts
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The inaccessible code
DNA is in the nucleus
Proteins are (mostly) made in the cytoplasm
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Decoding a codon: UGG
Only one way to code for tryptophan
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Decoding codons: AGC & AGU
Both code for serine!
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Stop codons Don’t code for an amino acid
They terminate translation
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RNA vs. DNA structureDNA RNA
linear polymer linear polymer
double-stranded single-stranded
deoxyribonucleotide
monomer
ribonucleotide
monomer
A,C,G,T bases A,C,G,U bases
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Transcription: DNARNA
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The Central Dogma
DNA
RNA
Protein
replication
transcription
translation