1 adrenergic antagonits. 2 adrenergic blockers alpha blockers alpha 1 blockers nonselective alpha...
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ADRENERGICADRENERGIC ANTAGONITS ANTAGONITS
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ADRENERGIC BLOCKERSADRENERGIC BLOCKERSALPHA BLOCKERS
Alpha 1 Blockers Nonselective Alpha
BlockersDoxazosin PhenoxybenzaminePrazosin PhentolamineTerazosin
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BETA BLOCKERSNon Selective Beta 1 selective
Blockers Blockers
Propranolol Metoprolol Timolol AtenololNadolol Esmolol Acebutolol Betaxolol Labetalol - Both Alpha and Beta BLocker
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DRUGS AFFECTING NEUROTRANSMITTER UPTAKE OR RELEASE
CocaineGuanethidineReserpine
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PhenoxybenzaminePhenoxybenzamine
Blocks alpha 1 and 2, irreversible blockade MOSTLY
Actions - prevents V.C,
Epinephrine reversal
Therapeutic uses : – Opposing catecholamines --pheochromocytoma– Causes vasodilation
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SE:Postural hypotensionSexual dysfunction TachycardiaContraindicated in ↓ coronary perfusion.
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PhentolaminePhentolamine
Alpha 1 and 2 blockerDuration of action lessUses & SE – mostly same as
Phenoxybenzamine.
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Alpha 1 specific blockersAlpha 1 specific blockers
PrazosinTerazosinDoxazosin – long acting
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Actions ----- Dose ---- Uses ----- Side effects ----
CVS Avoid high doses HTN
Orthostatic hypotension Nasal stuffiness Fatigue Sexual dysfunction
(less)
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Non selective beta antagonistsNon selective beta antagonists
PropranololTimololNadolol
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PropranololPropranolol
CVS – HR ↓ , CO ↓PERIPHERAL VESSELS – NO ALPHA
ACTIONBRONCHI - ↑ CONTRACTIONSODIUM LEVELS - ↑GLYCOGENOLYSIS -↓ GLUCAGON - ↓BLOCKS DRUGS – Isoproterenol , & β actions of epinephrine
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USESUSES
HTN ---- decreases COANGINA---decreases oxygen demandMI---- protects myocardiumGLAUCOMA-- TimololMIGRAINEHYPERTHYROIDISM– blunts
sympathetic stimulation
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SIDE EFFECTSSIDE EFFECTS
BRONCHOCONSTRICTIONCONTRAINDICATION –ASTHMA,
COPDARRHYTHMIAS – gradual reduction in
doseSEXUAL IMPAIREMENT
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NON SELECTIVE BETA NON SELECTIVE BETA ANTAGONISTSANTAGONISTS
TIMOLOLNADOLOL → very long duration of action
Considered more potent than propranolol.
Same effects and SE as propranolol.
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SELECTIVE BETA 1 SELECTIVE BETA 1 ANTAGONISTSANTAGONISTS
ATENOLOLMETOPROLOLESMOLOL
USES – HTN,ANGINACAN BE USED IN COPD, DM CASES
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ANTAGONISTS AND ANTAGONISTS AND PARTIAL AGONISTSPARTIAL AGONISTS
PINDOLOLACEBUTOLOL
USES : HTN with moderate bradycardia
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ALPHA AND BETA ALPHA AND BETA BLOCKERBLOCKER
LABETALOL
Peripheral vasodilation -- ↓ B.PNo vasoconstrictive effectUSES : OLD AGE HTN, PIHSE: Orthostatic hypotension and dizziness.
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NT AFFECTING DRUGSNT AFFECTING DRUGSRESERPINE
- CYTOPLASM TO STORAGE VESICLE
USES -- ↓B.P. ↓ H.R
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NT AFFECTING DRUGSNT AFFECTING DRUGS
GUANETHIDINE
–BLOCKS RELEASEOF NE IN VESICLE TO MEMBRANE
USES—gradual lowering of B.P and H.R. in hypertensives
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NT AFFECTING DRUGSNT AFFECTING DRUGS
COCAINE Block Na-K ATPaseREUPTAKE DECREASED (NE)USES ----local anesthetic???