1... a working tumor chemosensitivity assay (tca) could be of immense benefit to the pharmaceutical...

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Page 1: 1... A working tumor chemosensitivity assay (TCA) could be of immense benefit to the pharmaceutical industry, oncologists and their patients (Cree and
Page 2: 1... A working tumor chemosensitivity assay (TCA) could be of immense benefit to the pharmaceutical industry, oncologists and their patients (Cree and

1... A working tumor chemosensitivity assay (TCA) could be of immense benefit to the pharmaceutical industry, oncologists and their patients (Cree and Kurbacher, 1997)

2... ATP-TCA can be used to select patients who might benefit from specific chemotherapeutic agents alone or in combination (Cree et al, 1999)

Literature...

Continued...

Page 3: 1... A working tumor chemosensitivity assay (TCA) could be of immense benefit to the pharmaceutical industry, oncologists and their patients (Cree and

Results of Chemotherapy guided by the ATP-TCA

1... Retrospective clinical correlation in breast carcinoma (Cree et al, 1996): 97% assay evaluability, 76% accuracy, 27% improvement in clinical response rate

2... A greater benefit with regard to both ORR and PFS in platinum refractory patients (Kurbacher et al, 1998): Overall survival, 97 weeks / 69 weeks; Response rate, 64% / 37%

Page 4: 1... A working tumor chemosensitivity assay (TCA) could be of immense benefit to the pharmaceutical industry, oncologists and their patients (Cree and

TWO GREAT BENEFITS OBTAINED FROM CHEMOSENSITIVITY TESTING

• Exclusion of chemotherapeutic agents which are not likely to be effective, thereby avoidance of their potential toxicity

• Selection of chemotherapeutic agents with the greatest likelihood of clinical effectiveness for improved response rates and prolonged survival

Page 5: 1... A working tumor chemosensitivity assay (TCA) could be of immense benefit to the pharmaceutical industry, oncologists and their patients (Cree and

Briefly...

• It is considered that defective apoptosis is a feature of malignant development

• Enhancing apoptosis in malignancies is to be aimed

• Detection of apoptosis-related proteins may be of importance in the prediction of response to chemo- or radio-therapy as well as of survival rates

• Chemosensitivity testing seems to provide more realistic approaches to the treatment of malignancies, letting oncologists design the chemotherapy regimen on the basis of patient-specificity