NCSUniversity System

A Project of NCS Education System

Tanveer TaraSenior Lecturer

Bachelor of Science in MLTMasters of Science in Hematology

Qualitative abnormalities ofNeutrophil

Functional Abnormalities are always inherited.

Severe infection.Delay wound healing

Anti biotic Resistant Sepsi

Alders Reilly Anomaly• Alder anomaly is a rare autosomal recessive disorder in which

the basic defect involves in mucopolysaccharides due to various enzymes deficiencies.

• May expressed in all cell cell types,• Large purplish granules may occur in clusters, rather than

diffusely, throughout the cytoplasm as in toxic granulation. These inclusions may be seen in the bone marrow more frequently than in peripheral blood.

Alders Anomaly

Chediak Higashi ANOMALY

• Rare autosomal recessive.• Death usally occours in infancy or childhood.• Giant grey green peroxidase positive bodies

are found in cytoplasm.• Nuioutrophil: Abnormal fusion of granules.• Abnormal cells are ineffective in killing micro-

organism.

Chediak Higashi ANOMALY

• Patient have skin hypopegmintation,silver hairs and photophobia.

• Lymphadenopathy and hepatosplenomegaly.

MPO Deficiency

Myeloperoxidase (MPO) is a human enzyme in the azurophilic granules of neutrophils and in the lysosomes of monocytes. Its major role is to microbial killing.Benign Autosomal Recessive inherited disorderAbsence of MPO .The presence of myeloperoxidase (MPO) can be determined using numerous techniques, including histochemical staining, immunocytochemistry, and flow cytometry.

Eosinophilia

• Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds (450/µL). Eosinophils usually account for less than 7% of the circulating leukocytes.

• Eosinopenia is a form of agranulocytosis where the number of eosinophil granulocytes is lower than expected. Leukocytosis with eosinopenia can be a predictor of bacterial infection.

Basophilia

• Basophilia is a condition where the basophil quantity is abnormally elevated (more than 0.15X109 /Lbasophils per liter of blood).Basophilia is associated with Pruritis (itching) due to the basophils release of histamine.

• Basophilopenia: Very Rare .• CAUSES:CML .

STUDENT Assignment

• Causes of Leucocytosis and leucopenia .• Tabulated difference between PH,DHOLEE ,TOXIC GRANULATION.• TABULATED DIFFERENCE IN CH, MPO,AA• Normal values of Wbc full counts .

MONOCYTOSIS.

• Monocytosis is increase number of monocytes .Usally in recovery stage of acute infection.

• Sub Acute bacterial Endocarditis: Phagoytosis of other blood cells.

• Mycotic• Ricketsial • Protozonal • Parsitic infections

Monocytopenia

• A decrease in circulating monocytes below the lower refrence value .

Hairy cell leukemiaGluccortecosteriods therapy