03 guerra, rudy
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Rudy Guerra, PhDDepartment of Statistics,
Rice University
Statistical Genetics
•Heritability - phenotype caused in part by genes••Genotype-phenotype correlations
•Genetic Linkage (family studies)••Linkage disequilibrium (association)• - Population based samples
•Genes and environment
•Genome scans
Problems center on identifying and characterizingassociations between genes and phenotypes (diseases,cholesterol, plant height).
Bioinformatics: The New Era
The National Center for Biotechnology Information (2001)
Bioinformatics is the field of science in which biology, computer science, and information technology merge into a single discipline. There are three important sub-disciplines within bioinformatics: the development of new algorithms and statistics with which to assess relationships among members of large data sets; the analysis and interpretation of various types of data including nucleotide and amino acid sequences, protein domains, and protein structures; and the development and implementation of tools that enable efficient access and management of different types of information."
Hot spots Block
MicroarrayCorner of 2-sample cDNA slideCorner of Affymetrix Human chip
Areas of significant correlation on chr 4
Down Syndrome (Trisomy 21)
DNA copy number profiles of 57 medulloblastomas based on SNP array
Tum
or
Chromosome
6 7 171 22
Gain Loss
Rice Statistics Department: Statistical Genetics & BioinformaticsMajor Research Components of ResearchRudy Guerra Dennis CoxMarek Kimmel Javier RojoMarina Vannucci
Collaborators ApplicationsIntra-department Cancer, heart disease, metabolic syndrome,MD Anderson, BCM-TCH genomic disorders, obesity, cholesterol