OriginalThe All-on-4® treatment concept

1 surgeryNo time-consuming grafting procedures.

4 implantsTwo straight in the anterior, two tilted in the posterior.

1 fixed prosthesisProvisional full-arch restoration delivered on the day of surgery.*

* For patients meeting criteria for immediate loading of implants.

In a patient-

centered approach,

the aim should be

to avoid more

invasive procedures,

such as grafting,

when a more limited

number of implants

offers the same

reliable long-term

outcome. 1

OriginalFrom the pioneer in full-arch restorations

Today2004

Per-Ingvar Brånemark treats his first patient Gösta Larsson with a full-arch restoration.

1965

Dr Paulo Malo treats the first patient using the All-on-4® treatment concept.

Launch of the All-on-4® treatment concept

1998

Hundreds of thousands of patients have been treated with the All-on-4® treatment concept.

ProvenHigh survival rates

at 10 years in the mandible4

94.8 %

at 5 years in the maxilla3

98.0 % at 3 years2

99.0 %

0 6 1812 24 30 36 42 48 54 60

Time after implant placement [months]

–0.2

–0.4

–0.6

–0.8

–1.0

–1.2

–1.4

–0.0

Mar

gin

al b

one

leve

l cha

nge

[mm

]

ProvenStable bone levels 5 – 9 and healthy soft tissue 6

Favorable bone remodeling for both tilted and axial implants 5

Implants immediately loaded with radiographic baseline set at time of insertion. Therefore all bone remodeling is reported. Graph shows results for mandible, but results for maxilla are similar. The asterisks (*) indicate a statistically significant difference (p=0.03).5

Tilted implants

Axial implants

ProvenOften copied, never equaled

Many have tried to copy the All-on-4® treatment concept, but only Nobel Biocare has scientifically documented success.2,10

Nobel BiocareAll-on-4®

Straumann®Pro Arch

clinical studiesclinical studies0 34

0 patients >2400 patients

0 implants >9250 implants

Life changingImmediate quality of life on the day of treatment

Conventional treatment

All-on-4® treatment concept

Bone grafting and adaptation of removable denture.

Implant placement and adaptation of removable denture.

Placement of fixed restoration.

6 months1st day

1 day

9 months

Implant placement and fixed provisional restoration in one visit.*

* For patients meeting criteria for immediate loading of implants.

OriginalFrom the pioneer in full-arch restorations

Today2004

Per-Ingvar Brånemark treats his first patient Gösta Larsson with a full-arch restoration.

1965

Dr Paulo Malo treats the first patient using the All-on-4® treatment concept.

Launch of the All-on-4® treatment concept

1998

Hundreds of thousands of patients have been treated with the All-on-4® treatment concept.

ProvenHigh survival rates

at 10 years in the mandible4

94.8 %

at 5 years in the maxilla3

98.0 % at 3 years2

99.0 %

0 6 1812 24 30 36 42 48 54 60

Time after implant placement [months]

–0.2

–0.4

–0.6

–0.8

–1.0

–1.2

–1.4

–0.0

Mar

gin

al b

one

leve

l cha

nge

[mm

]

ProvenStable bone levels 5 – 9 and healthy soft tissue 6

Favorable bone remodeling for both tilted and axial implants 5

Implants immediately loaded with radiographic baseline set at time of insertion. Therefore all bone remodeling is reported. Graph shows results for mandible, but results for maxilla are similar. The asterisks (*) indicate a statistically significant difference (p=0.03).5

Tilted implants

Axial implants

ProvenOften copied, never equaled

Many have tried to copy the All-on-4® treatment concept, but only Nobel Biocare has scientifically documented success.2,10

Nobel BiocareAll-on-4®

Straumann®Pro Arch

clinical studiesclinical studies0 34

0 patients >2400 patients

0 implants >9250 implants

Life changingImmediate quality of life on the day of treatment

Conventional treatment

All-on-4® treatment concept

Bone grafting and adaptation of removable denture.

Implant placement and adaptation of removable denture.

Placement of fixed restoration.

6 months1st day

1 day

9 months

Implant placement and fixed provisional restoration in one visit.*

* For patients meeting criteria for immediate loading of implants.

Life changingLess pain and lower costs

Conventional treatment

All-on-4® treatment conceptShorter treatmentLess pain 1

Lower costs 11

Life changingHigh patient satisfaction

With regards to function, esthetics, sense, speech, and self-esteem.11

98% of patients would recommend this treatment.

95% of patients are satisfied with their new teeth.

74 %extremelysatisfied

88 %definitelyrecommend

21%satisfied

10 % considerrecommending to a friend

Life changingLess pain and lower costs

Conventional treatment

All-on-4® treatment conceptShorter treatmentLess pain 1

Lower costs 11

Life changingHigh patient satisfaction

With regards to function, esthetics, sense, speech, and self-esteem.11

98% of patients would recommend this treatment.

95% of patients are satisfied with their new teeth.

74 %extremelysatisfied

88 %definitelyrecommend

21%satisfied

10 % considerrecommending to a friendLife changing

Increasing demand

20 %of the adult world population is affected by complete edentulism.1

Patients are increasingly aware of treatment options and the benefits of implant-based treatments.

Life changingThe solution that grows your practice

24 % of dental professionals that attended a Nobel Biocare All-on-4® course ... ... grow their number

of placed implants by more than

50 %in the nextyear.13

1 Patient centered management and optimal number of implants in the treatment of edentulism – A consensus conference. Eur J Oral Implantol 7 (2014), No. 2 (24.06.2014)

2 Patzelt SB, Bahat O, Reynolds MA, Strub JR. The All-on-Four Treatment Concept: A Systematic Review. Clin Implant Dent Relat Res 2014;16(6):836-55

3 Malo P, de Araujo Nobre M, Lopes A, Francischone C, Rigolizzo M. “All-on-4” Immediate-Function Concept for Completely Edentulous Maxillae: A Clinical Report on the Medium (3 Years) and Long-Term (5 Years) Outcomes. Clin Implant Dent Relat Res 2012;14 Suppl 1:e139-50

4 Malo P, de Araujo Nobre M, Lopes A, Moss SM, Molina GJ. A longitudinal study of the survival of All-on-4 implants in the mandible with up to 10 years of follow-up. J Am Dent Assoc 2011;142(3):310-20

5 Francetti L, Romeo D, Corbella S, Taschieri S, Del Fabbro M. Bone Level Changes Around Axial and Tilted Implants in Full-Arch Fixed Immediate Restorations. Interim Results of a Prospective Study. Clin Implant Dent Relat Res 2012;14:646-54

6 Agliardi E, Panigatti S, Clericò M, Villa C, Malò P. Immediate rehabilitation of the edentulous jaws with full fi xed prostheses supported by four implants: interim results of a single cohort prospective study. Clin Oral Implants Res 2010;21:459-65

7 Balshi TJ, Wolfi nger GJ, Slauch RW, Balshi SF. A retrospective analysis of 800 Brånemark System implants following the All-on-Four™ protocol. J Prosthodont 2014;23:83-8

8 Weinstein R, Agliardi E, Fabbro MD, Romeo D, Francetti L. Immediate rehabilitation of the extremely atrophic mandible with fi xed full-prosthesis supported by four implants. Clin Implant Dent Relat Res 2012;14:434-41

9 Mozzati M, Arata V, Gallesio G, Mussano F, Carossa S. Immediate Postextractive Dental Implant Placement with Immediate Loading on Four Implants for Mandibular-Full-Arch Rehabilitation: A Retrospective Analysis. Clin Implant Dent Relat Res 2013;15:332-40

10 Data on fi le (REP 134625 v03, May 03, 2016 and REP 146920 v00, April 22, 2016)11 Babbush CA, Kanawati A, Kotsakis GA, Hinrichs JE. Patient-Related and Financial Outcomes Analysis of

Conventional Full-Arch Rehabilitation Versus the All-on-4 Concept: A Cohort Study. Implant Dent 2014;23(2):218–24

12 Al-Quran FA, Al-Ghalayini RF, Al-Zu’bi BN. Single-tooth replacement: factors affecting different prosthetic treatment modalities. BMC Oral Health. 2011 Dec 21;11:34

13 Data on fi le: comparing annual increase in customer net sales (2013-2014)

GMT 47772 GB 1609 © Nobel Biocare Services AG, 2016. All rights reserved. Nobel Biocare, the Nobel Biocare logotype and all other trademarks are, if nothing else is stated or is evident from the context in a certain case, trademarks of Nobel Biocare. Please refer to nobelbiocare.com/trademarks for more information. Product images are not necessarily to scale. Disclaimer: Some products may not be regulatory cleared/released for sale in all markets. Please contact the local Nobel Biocare sales offi ce for current product assortment and availability. For prescription use only. Caution: Federal (United States) law restricts this device to sale by or on the order of a licensed dentist. See Instructions for Use for full prescribing information, including indications, contraindications, warnings and precautions.

References

Life changingIncreasing demand

20 %of the adult world population is affected by complete edentulism.1

Patients are increasingly aware of treatment options and the benefits of implant-based treatments.

Life changingThe solution that grows your practice

24 % of dental professionals that attended a Nobel Biocare All-on-4® course ... ... grow their number

of placed implants by more than

50 %in the nextyear.13

1 Patient centered management and optimal number of implants in the treatment of edentulism – A consensus conference. Eur J Oral Implantol 7 (2014), No. 2 (24.06.2014)

2 Patzelt SB, Bahat O, Reynolds MA, Strub JR. The All-on-Four Treatment Concept: A Systematic Review. Clin Implant Dent Relat Res 2014;16(6):836-55

3 Malo P, de Araujo Nobre M, Lopes A, Francischone C, Rigolizzo M. “All-on-4” Immediate-Function Concept for Completely Edentulous Maxillae: A Clinical Report on the Medium (3 Years) and Long-Term (5 Years) Outcomes. Clin Implant Dent Relat Res 2012;14 Suppl 1:e139-50

4 Malo P, de Araujo Nobre M, Lopes A, Moss SM, Molina GJ. A longitudinal study of the survival of All-on-4 implants in the mandible with up to 10 years of follow-up. J Am Dent Assoc 2011;142(3):310-20

5 Francetti L, Romeo D, Corbella S, Taschieri S, Del Fabbro M. Bone Level Changes Around Axial and Tilted Implants in Full-Arch Fixed Immediate Restorations. Interim Results of a Prospective Study. Clin Implant Dent Relat Res 2012;14:646-54

6 Agliardi E, Panigatti S, Clericò M, Villa C, Malò P. Immediate rehabilitation of the edentulous jaws with full fi xed prostheses supported by four implants: interim results of a single cohort prospective study. Clin Oral Implants Res 2010;21:459-65

7 Balshi TJ, Wolfi nger GJ, Slauch RW, Balshi SF. A retrospective analysis of 800 Brånemark System implants following the All-on-Four™ protocol. J Prosthodont 2014;23:83-8

8 Weinstein R, Agliardi E, Fabbro MD, Romeo D, Francetti L. Immediate rehabilitation of the extremely atrophic mandible with fi xed full-prosthesis supported by four implants. Clin Implant Dent Relat Res 2012;14:434-41

9 Mozzati M, Arata V, Gallesio G, Mussano F, Carossa S. Immediate Postextractive Dental Implant Placement with Immediate Loading on Four Implants for Mandibular-Full-Arch Rehabilitation: A Retrospective Analysis. Clin Implant Dent Relat Res 2013;15:332-40

10 Data on fi le (REP 134625 v03, May 03, 2016 and REP 146920 v00, April 22, 2016)11 Babbush CA, Kanawati A, Kotsakis GA, Hinrichs JE. Patient-Related and Financial Outcomes Analysis of

Conventional Full-Arch Rehabilitation Versus the All-on-4 Concept: A Cohort Study. Implant Dent 2014;23(2):218–24

12 Al-Quran FA, Al-Ghalayini RF, Al-Zu’bi BN. Single-tooth replacement: factors affecting different prosthetic treatment modalities. BMC Oral Health. 2011 Dec 21;11:34

13 Data on fi le: comparing annual increase in customer net sales (2013-2014)

GMT 47772 GB 1609 © Nobel Biocare Services AG, 2016. All rights reserved. Nobel Biocare, the Nobel Biocare logotype and all other trademarks are, if nothing else is stated or is evident from the context in a certain case, trademarks of Nobel Biocare. Please refer to nobelbiocare.com/trademarks for more information. Product images are not necessarily to scale. Disclaimer: Some products may not be regulatory cleared/released for sale in all markets. Please contact the local Nobel Biocare sales offi ce for current product assortment and availability. For prescription use only. Caution: Federal (United States) law restricts this device to sale by or on the order of a licensed dentist. See Instructions for Use for full prescribing information, including indications, contraindications, warnings and precautions.

References

OriginalThe original graftless full-arch solution on four implants.

OriginalThe original graftless full-arch solution on four implants.

ProvenThe proven long-term solution.

ProvenThe proven long-term solution.

Life changingThe solution that changes your patients’ lives and grows your practice.

Life changingThe solution that changes your patients’ lives and grows your practice.

OriginalThe original graftless full-arch solution on four implants.

ProvenThe proven long-term solution.

Life changingThe solution that changes your patients’ lives and grows your practice.

All-on-4® treatment conceptScience First

OriginalThe All-on-4® treatment concept

1 surgeryNo time-consuming grafting procedures.

4 implantsTwo straight in the anterior, two tilted in the posterior.

1 fixed prosthesisProvisional full-arch restoration delivered on the day of surgery.*

* For patients meeting criteria for immediate loading of implants.

In a patient-

centered approach,

the aim should be

to avoid more

invasive procedures,

such as grafting,

when a more limited

number of implants

offers the same

reliable long-term

outcome. 1

OriginalThe original graftless full-arch solution on four implants.

ProvenThe proven long-term solution.

Life changingThe solution that changes your patients’ lives and grows your practice.

All-on-4® treatment conceptScience First