* wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin
TRANSCRIPT
![Page 1: * Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin](https://reader036.vdocuments.mx/reader036/viewer/2022062518/5697bf921a28abf838c8effd/html5/thumbnails/1.jpg)
* Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin
![Page 2: * Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin](https://reader036.vdocuments.mx/reader036/viewer/2022062518/5697bf921a28abf838c8effd/html5/thumbnails/2.jpg)
Extracellular signal molecule
Receptor protein
Intracellular signaling proteins
Target proteins
Metabolic enzyme
Gene regulatory protein
Cytoskeletal protein
![Page 3: * Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin](https://reader036.vdocuments.mx/reader036/viewer/2022062518/5697bf921a28abf838c8effd/html5/thumbnails/3.jpg)
Extracelluar signal
molecules bind to specific receptors
![Page 4: * Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin](https://reader036.vdocuments.mx/reader036/viewer/2022062518/5697bf921a28abf838c8effd/html5/thumbnails/4.jpg)
Three classes of cell-surface receptors
oror
![Page 5: * Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin](https://reader036.vdocuments.mx/reader036/viewer/2022062518/5697bf921a28abf838c8effd/html5/thumbnails/5.jpg)
Gene transcription is activated by a rise in cAMP conc
Relay protein
Amplifier and transducer protein
Messenger protein
![Page 6: * Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin](https://reader036.vdocuments.mx/reader036/viewer/2022062518/5697bf921a28abf838c8effd/html5/thumbnails/6.jpg)
MAP-kinase serine/threonine phosphorylation pathway activated by
Ras
Raf
MEK
MAPK
![Page 7: * Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin](https://reader036.vdocuments.mx/reader036/viewer/2022062518/5697bf921a28abf838c8effd/html5/thumbnails/7.jpg)
Cytokine receptors activate the Jak-STAT signaling pathway
JAKsJAK1JAK2JAK3Tyk2
Signal transducers and activators of transcription
![Page 8: * Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin](https://reader036.vdocuments.mx/reader036/viewer/2022062518/5697bf921a28abf838c8effd/html5/thumbnails/8.jpg)
* Wnt proteins bind to frizzled receptors and inhibit the degradation of -catenin