Research Update 2018 SpringNeurology, Sakura Medical Center , Toho University

Our research goal is:First, to develop a clear way of early diagnosis and treatment of the patients, using advanced neuroimaging (MRI tensor & curtosis imaging, functional brain mapping of autonomic stimulation), cerebrospinal fluid analysis (alpha synuclein, separating repeat-numbers of phosphorylated tau, oxidative stress, neuro-immunology), neurophysiology, cognitive testing, and advanced autonomic testing (bladder electro-sensation & video urodynamics, upper & lower gut motility).  Second, to develop a clear way of management and care for the patients, using patient-oriented care by a Neuro-Team from the functional recovery of aphasia to the bladder care.Just kick on, join and research together!

ISAN international society of autonomic nervous system in Nagoya 2017 September

ISAN international society of autonomic nervous system in Nagoya 2017 SeptemberUpper figure: Hitsumabushi, a traditional Japanese cuisine of eel.

ICS international continence society 2017 Florence, Italy. Montepulciano. The Heart of Wine. September

ICS international continence society 2017 Florence, Italy. Chairman’s reception, Palazzo Borghese, September

WCN world congress of neurology Kyoto 2017 September

WCN world congress of neurology Kyoto 2017 September

INUS international neuro-urology society 2018 Zurich, January.

INUS international neuro-urology society 2018 Zurich, January.

Paper: 1 An International Continence Society (ICS) report on the terminology for adult neurogenic lower urinary tract

dysfunction (ANLUTD). Gajewski JB, Schurch B, Hamid R, Averbeck M, Sakakibara R, Agrò EF, Dickinson T, Payne CK, Drake MJ, Haylen BT. Neurourol Urodyn. 2017 Nov 17. doi: 10.1002/nau.23397. [Epub ahead of print]

2 Urological dysfunction in synucleinopathies: epidemiology, pathophysiology and management. Sakakibara R, Tateno F, Yamamoto T, Uchiyama T, Yamanishi T. Clin Auton Res. 2017 Nov 9. doi: 10.1007/s10286-017-0480-0. [Epub ahead of print] Review.

3 The prevalence, course and clinical correlates of migraine in Parkinson's disease: A multicentre case-controlled study. Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Kaji Y, Hirano S, Suzuki S, Haruyama Y, Kobashi G, Hirata K; Kanto NMPD investigators. Cephalalgia. 2017 Jan 1:333102417739302. doi: 10.1177/0333102417739302. [Epub ahead of print]

4 Postvoid residual predicts the diagnosis of multiple system atrophy in Parkinsonian syndrome. Yamamoto T, Asahina M, Yamanaka Y, Uchiyama T, Hirano S, Fuse M, Koga Y, Sakakibara R, Kuwabara S. J Neurol Sci. 2017 Oct 15;381:230-234.

5 Impact of sleep-related symptoms on clinical motor subtypes and disability in Parkinson's disease: a multicentre cross-sectional study. Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Kaji Y, Hirano S, Kadowaki T, Hirata K; Kanto NMPD investigators. J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):953-959.

6 Editorial Comment from Dr Sakakibara to Case of possible multiple system atrophy with a characteristic imaging finding of open bladder neck during storage phase as an initial sign. Sakakibara R. Int J Urol. 2017 Nov;24(11):819-820.

7 Characterizing restless legs syndrome and leg motor restlessness in patients with Parkinson's disease: A multicenter case-controlled study. Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Kaji Y, Hirano S, Numao A, Hirata K; Kanto NMPD investigators. Parkinsonism Relat Disord. 2017 Nov;44:18-22.

8 Genetic Screening for Spinocerebellar Ataxia Genes in a Japanese Single-Hospital Cohort. Sakakibara R, Tateno F, Kishi M, Tsuyusaki Y, Aiba Y, Terada H, Inaoka T, Sawai S, Kuwabara S, Nomura F. J Mov Disord. 2017 Sep;10(3):116-122.

9 Anticoagulant-Free but Dangerous: Perisurgical Consideration. Aiba Y, Sakakibara R, Tsuyusaki Y, Kishi M, Tateno F, Ogata T, Nagao T, Terada H, Inaoka T. J Stroke Cerebrovasc Dis. 2017 Sep;26(9):2038-2040.

10 Neurogenic bowel dysfunction: Clinical management recommendations of the Neurologic Incontinence Committee of the Fifth International Consultation on Incontinence 2013. Cotterill N, Madersbacher H, Wyndaele JJ, Apostolidis A, Drake MJ, Gajewski J, Heesakkers J, Panicker J, Radziszewski P, Sakakibara R, Sievert KD, Hamid R, Kessler TM, Emmanuel A. Neurourol Urodyn. 2017 Jun 22. doi: 10.1002/nau.23289. [Epub ahead of print] Review.

11 Seiza-induced neuropathy: an occupational peroneal neuropathy in a Japanese lady. Kishi M, Sakakibara R, Takahashi O, Nakamura H, Tateno F, Tsuyusaki Y, Aiba Y, Ogata T, Suzuki Y. Neurol Sci. 2017 Aug;38(8):1521-1522.

12 The Utility of Post-Void Residual Volume versus Sphincter Electromyography to Distinguish between Multiple System Atrophy and Parkinson's Disease. Yamamoto T, Asahina M, Yamanaka Y, Uchiyama T, Hirano S, Fuse M, Koga Y, Sakakibara R, Kuwabara S. PLoS One. 2017 Jan 6;12(1):e0169405. doi: 10.1371/journal.pone.0169405.

13 Diagnostic imaging of dementia with Lewy bodies by susceptibility-weighted imaging of nigrosomes versus striatal dopamine transporter single-photon emission computed tomography: a retrospective observational study. Kamagata K, Nakatsuka T, Sakakibara R, Tsuyusaki Y, Takamura T, Sato K, Suzuki M, Hori M, Kumamaru KK, Inaoka T, Aoki S, Terada H. Neuroradiology. 2017 Jan;59(1):89-98.

14 Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy. Ogawa T, Sakakibara R, Kuno S, Ishizuka O, Kitta T, Yoshimura N. Nat Rev Urol. 2017 Feb;14(2):79-89. 　

Neural cirxuit relevant to micturition.

Basal ganglia cirxuit relevant to micturition. (Ref. No.2)

Urological dysfunction in synucleinopathies: epidemiology, pathophysiology and management. Sakakibara R, Tateno F, Yamamoto T, Uchiyama T, Yamanishi T. Clin Auton Res. 2017 Nov 9. doi: 10.1007/s10286-017-0480-0. [Epub ahead of print] Review.

Book chapter: 1 Apostolidis A, Drake MJ, Emmanuel A, Gajewski J, Hamid R, Heesakkers J, Kessler T, Madesbacher H, Mangera

A, Panicker J, Radziszewski P, Sakakibara R, Sivert KD, Wyndaele JJ. Committee 10: Neurogenic fecal incontinence. In: ICI International Consultation on Incontinence: Abrams P, Cardozo L, Wagg A, Wein A eds., Incontinence, 6th Edition, ICUD publisher, 2017: 1095-1280.

(Ref. No.1,2)ICI International Consultation on Incontinence was originally held with the endorsement of WHO World Health

Organization, which is now taken place once per 2-4 years. ICI is the multidisciplinary group to study and prevail

continence medicine. This book is a report of ICI 2016 Tokyo meeting (held during ICS 2016 Tokyo meeting).

Symposium, special lecture1 Sakakibara R. Skill Workshop (Educational Course). Novel insights into bladder and sexual dysfunction in

Parkinson’s disease. International Parkinson and Movement Disorder Society MDS 2017, Vancouver, Canada, 2017. 6.7

2 R. Sakakibara. Symposium. Synycleinopathies from autonomic point of view. Journal of the Neurological Sciences, Vol. 381, p16 Published in issue: October 15, 2017 23rd World Congress of Neurology 2017, Kyoto, 2017.9.16-21.

3 R. Sakakibara. Symposium. Autonomic bladder disorders in dementia with Lewy bodies. 70th The International Society for Autonomic Neuroscience 2017, Nagoya, 2017.8.31-9.2

4 Uchiyama T, Sakakibara R. Symposium. Autonomic bladder disorders in stroke. 70th The International Society for Autonomic Neuroscience 2017, Nagoya, 2017.8.31-9.2

Meeting

1 Sakakibara R, Tateno F. Stercoral ulcer and colonic perforation in a Parkinson’s disease patient with constipation. Asian Neurogastroenterology & Motility Association (ANMA) & Japanese Society of Neurogastroenterology & Motility (JSNM) Joint Meeting 2017, Nagoya, 2017.3.23-25.

2 Sakakibara R. Wearable gait sensors to measure degenerative cerebellar ataxia. International Parkinson and Movement Disorder Society MDS 2017, Vancouver, Canada, 2017. 6.7

3 Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Hirata K, Kanto NMPD investigators. Headache and migraine in Parkinson’s disease: a multicenter cross-sectional study. International Headache Society 2017, Vancouver, Canada, 2017.9.7-10.

4 Tateno f1, Sakakibara r1, Aiba y1, Tsuyusaki y1, Kishi m1, Ri h2, Takahashi o3, Nakamura h3, Sugiyama m3. The relationship between lower urinary tractfunction and 123i- ioflupane scintigraphyin Parkinson’s disease. International Continence Society in Florence, Italy, 2017.9.12-15.

5 Sakakibara r1, Takahashi o2, Tateno f1, Kishi m1, Tsuyusaki y1, Aiba y1, Lee h3, Yamamoto t4, Shibata c5, Uchiyama t5, Yamanishi t5. Relationship between bladder, periarterial and somatic neuropathy in diabetes. International Continence Society in Florence, Italy, 2017.9.12-15.

6 Sakakibara r1, Tateno f1, Takahashi o2, Kishi m1, Tsuyusaki y1, Aiba y1, Lee h3, Yamamoto t4, Shibata c5, Uchiyama t5, Yamanishi t5. Parkinson’s disease and prostate hyperplasia: which is more contributing to overactive bladder? International Continence Society in Florence, Italy, 2017.9.12-15.

7 Sakakibara r1, Sugiyama m2, Tateno f1, Takahashi o2, Nakamura h2, Kishi m1, Tsuyusaki y1, Aiba y1, Lee h3, Yano m3, Suzuki h3. Bladder first-sensation-volume increase is primary in diabetic neuropathy: a five-grade measure. International Continence Society in Florence, Italy, 2017.9.12-15.

8 Uchiyama t1, Yamamoto t2, Higuchi y3, Suzuki k4, Kadowaki t4, Fujita h4, Watanabe y4, Kaga k5, Yamanishi t5, Sakakibara r6, Hirata k4, Kuwabara s2. Association between abnormal circadian rhythm of melatonin secretion and nocturnal polyuria in patients with Parkinson’s disease. International Continence Society in Florence, Italy, 2017.9.12-15.

9 Shibata c1, Ishii t2, Kanya k3, Mayuko k3, Miki f4, Oikawa s5, Hishinuma a5, Sakakibara r6, Yamanishi t3, Igarashi t2. The morphological characteristics of the bladder contraction in female. International Continence Society in Florence, Italy, 2017.9.12-15.

10 Yamamoto t1, Asahina m1, Yamanaka y1, Uchiyama t2, Hirano s1, Fuse m3, Koga y4, Sakakibara r5, Kuwabara s1. Large postvoid residual is a strong predictor of the diagnosis of multiple system atrophy in patients with parkinsonian syndrome. International Continence Society in Florence, Italy, 2017.9.12-15.

11 Sakakibara r1, Doi h2, Tateno f1, Kishi m1, Tsuyusaki y1, Ogata t1, Aiba y1. Gatrointestinal dysfunction in dementia with Lewy bodies: a comparison with Parkinson’s disease. International Continence Society in Florence, Italy, 2017.9.12-15.

12 Y. Aiba, R. Sakakibara, Y. Tsuyusaki, F. Tateno, M. Kishi, T. Ogata. Antithrombotic-free but dangerous: Post-surgical consideration. Journal of the Neurological Sciences, Vol. 381, p390 Published in issue: October 15, 2017 23rd World Congress of Neurology 2017, Kyoto, 2017.9.16-21.

13 R. Sakakibara, K. Terayama, A. Ogawa, H. Haruta, T. Akiba, F. Tateno, M. Kishi, Y. Tsuyusaki, and others. Wearable gait sensors to measure degenerative cerebellar ataxia. Journal of the Neurological Sciences, Vol. 381, p56–57 Published in issue: October 15, 2017 23rd World Congress of Neurology 2017, Kyoto, 2017.9.16-21.

14 R. Sakakibara, H. Doi, F. Tateno, M. Kishi, Y. Tsuyusaki, T. Ogata, Y. Aiba. Gatrointestinal dysfunction in dementia with lewy bodies: A comparison with Parkinson’s disease. Journal of the Neurological Sciences, Vol. 381, p115 Published in issue: October 15, 201 23rd World Congress of Neurology 2017, Kyoto, 2017.9.16-21.

15 K. Suzuki, Y. Okuma, T. Uchiyama, M. Miyamoto, R. Sakakibara, Y. Shimo, N. Hattori, S. Kuwabara, and others. The effect of sleep-related symtpoms on clinical motor subtype and disease-related disability in parkinson’s disease: A multicenter, cross-sectional study. Journal of the Neurological Sciences, Vol. 381, p178 Published in issue: October 15, 2017 23rd World Congress of Neurology 2017, Kyoto, 2017.9.16-21.

16 M. Kishi, S. Mori, K. Shigemoto, H. Nakamura, O. Takahashi, R. Sakakibara, Y. Tuyusaki, F. Tateno, and others. Low-density lipoprotein receptor-related protein 4 (LRP4) antibody positive myasthenia gravis: Electrophysiological evaluations in model mice (IN VITRO) and a patient. Journal of the Neurological Sciences, Vol. 381, p475 Published in issue: October 15, 2017 23rd World Congress of Neurology 2017, Kyoto, 2017.9.16-21.

17 R. Sakakibara. Parkinson’s disease and prostate hyperplasia: which is more contributing to overactive bladder?. 70th The International Society for Autonomic Neuroscience 2017, Nagoya, 2017.8.31-9.2

18 R. Sakakibara. Gastrointestinal dysfunction in dementia with Lewy bodies: a comparison with Parkinson’s disease. 70th The International Society for Autonomic Neuroscience 2017, Nagoya, 2017.8.31-9.2

19 Tateno F, Sakakibara R. Relationship between lower urinary tract dysfunction and 123I-ioflupane scintigraphy in Parkinson’s disease. 70th The International Society for Autonomic Neuroscience 2017, Nagoya, 2017.8.31-9.2