Carlos F Martino150 W University Blvd 424 LNKS

Melbourne, Fl 32901cmartino@fit.edu

EDUCATION

Florida Institute of TechnologyGraduate courses in Applied Mathematics08/15Applied Mathematics

University of Colorado - Boulder PhD in Mechanical Engineering 12/08Concentration in Biomedical Engineering/BioengineeringElectromagnetic stimulation of biological systems, reactive oxygen species, tissue engineering, systems biology, vascularization, mechanism of interaction between electromagnetic fields and biological systems, electrodynamics of continua

University of Colorado-BoulderMaster in Mathematics 5/07Diffusion, stochastic differential equations, stochastic processes, mathematical elasticity

University of Colorado - Denver Master of Science in Mechanical Engineering8/04Concentration in physics of materials: continuum mechanics, finite elasticity, electrodynamics of continuous media, analytical methods in fracture mechanics, physics of phonons, group theoretical methods in material science

University of Houston Bachelor of Science in Physics with Minor in Mathematics8/00Quantum mechanics, statistical physics, thermokinetics

EXPERIENCE

Assistant Professor 7/14 - PresentBiomedical Engineering DepartmentFlorida Institute of Technology

Visiting Research ProfessorUniversity of Paris VIC.N.R.S UMR 82561/14 – Present

Research Engineer femu – Forschungszentrum für Elektro-Magnetische Umweltverträglichkeit Uniklinik RWTH Aachen

2/14 – 06/14Conducts interdisciplinary research on biological and medical effects of electromagnetic fields in implants. Research includes electromagnetic provocation studies in patients using cardiac pacemakers. Duties include setting up patients for provocation studies, delivering interfering signal, acquiring and analyzing pacemaker signal activity, modeling interference voltage in bipolar electrode leads. Programs used include ANSYS, Matlab, LabView. Works closely with nurses and cardiologist. Assistant Professor 7/11-12/13Mechanical Engineering DepartmentUniversity of Nevada RenoServe as Principal Investigator and Project Manager in the Department’s Bioelectromagnetics Laboratory. Supervise two post-doctoral scientist, two graduate students, and one undergraduate student. Prepare program budgets, research and write proposals, and lead weekly meeting in which group members present research data, and analyze and interpret research results. Analyze group’s problems and challenges to identify solutions.

Key Accomplishments:Established bioengineering laboratory focused on micro-continuum mechanics of cells and bio-fluids, and mitochondria metabolism dysfunction after electromagnetic field exposure. Perform research in Systems Biology, with the goal to elucidate the molecular mechanism of magnetosensing in the mitochondrial reactive oxygen species (ROS), and to probe the involvement of different mitochondrial protein complexes. Research neuroscience applications, including Parkinson’s disease through Paraquat-induced ROS modulated electromagnetic fields, with the possibility of discovering potential metabolic pathways for targeting specific ROS treatment protocols in neurodegenerative disease states.Conducted project planning, direction, and execution for three major research projects.Submitted more than $2 million in grant applications to the National Science Foundation, National Institute of Health, and the Air Force Office of Scientific Research.

Research Associate 1/11- 7/11Physics Department, University of California IrvineSupervisor: Associate Professor Thorsten RitzConducted research in theoretical and experimental studies of electromagnetic field effects.Key Accomplishment:Initiated an international research program with University of Paris VI to investigate cryptochrome-mediated biomagnetic field effects. Research efforts included investigating the molecular basis of magnetic responses in a variety of organisms, particularly models amenable to genetic approaches such as plants (Arabidopsis) or fruit flies (Drosophilia).

Research Associate 6/09- 1/11Department of Electrical and Computing Engineering, University of Colorado BoulderSupervisor: Distinguished Professor Frank BarnesConducted research on a mixture of electrical engineering, physics, chemistry, and biology, with an emphasis on weak magnetic field effects on cellular physiology.Key Accomplishment:Topics included the development of theoretical models for the effects of electrical and magnetic fields on biological systems.

TECHNISCHE UNIVERSITÄT MÜNCHEN, Garching, Germany Visiting Research Fellow, Lehrstuhl für Medizintechnik, 7/15/06 - 5/15/08Received research fellowship in the Division of Biomedical Engineering to investigate the response and function of human umbilical vein endothelial cells to external electromagnetic fields.Key Accomplishment:Project included the morphological characterization of culture, cell proliferation, actin staining using fluorescent microscopy to analyze cytoskeleton, and expression profiling.

Research proof-of-principle for a vascular graft technique

UNIVERSITY OF COLORADO BOULDER, Boulder, CO Physics Specialist, Student Academic Service Center, 8/01/04 - 5/15/06Graduate Assistant, Mechanical Engineering DepartmentDeveloped physics co-seminars that emphasized applications in engineering, biology, and medicine. Taught algebra and calculus-based physics to freshmen entering biological and engineering disciplines. Conducted teaching, graded homework, and consulted with and supported students.Key Accomplishments:Investigated the effects of pulsed electromagnetic fields in mineralization process of osteoblast-like cells, identifying parameters responsible for osteogenic responses.

NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, Boulder, CO Graduate Student, Materials Reliability Division, 11/01/02 - 6/01/04Developed analysis techniques to determine elastic properties of materials using noncontacting electromagnetic excitation of acoustic modes. Research included group theoretical analysis for determining vibrational modes and stresses symmetry.Key Accomplishment:Completed Mechanical Engineering Master’s Thesis: “Mode-Selective Acoustic Resonance Spectroscopy of Trigonal Crystals.”

UNIVERSITY OF HOUSTON, Houston, TX Undergraduate Assistant, Semiconductor Physics Laboratory, 5/01/98 - 6/01/00Research tasks included sample preparation, MBE chamber operation, and electrical characterization.Key Accomplishments:Conducted experimental investigation of dielectric crystals and their layered composition as thin films

RESEARCH INTERESTS

Bioelectromagnetism Neuroscience Synthetic Biology/Systems Biology Mitochondrial metabolic functioning in external magnetic fields/Bioenergy Tunable phononic crystals Microcontinuum mechanics and applied mechanics, Mathematical modeling

HONORS AND AWARDS

Deutscher Akademischer Austausch Dienst (DAAD) Research Fellowship (~$15,000) 7/06-1/07Bioelectrochemistry Society Carl Storm Under-represented Minority Fellowship 9/06Gordon Research Conference, Modane France Bioelectromagnetic Society Scholarship 6/0628th Annual BEMS Conference, Cancun MexicoUniversity of Colorado Boulder Graduate Grants 8/05-5/07

LANGUAGES

Fluent in Spanish, English, Basic understanding of German

STUDENTS ADVISED

Master’s Thesis Cristina Mazzone --- MS in Biomedical Eng. at Florida Tech Thesis: Quantum Biology of Reactive Oxygen Species: Magnetic Fields and Bioenergetics

Ph.D. Students Louis David --- PhD Student at University of Paris et Marie Curie Mayhar Sameti, Ph.D student with Dr. Bashur Merfat Hammad Meznah Albaqami

Master’s Students Ian McClure Matthew Kraska Rashad Abdulla

Undergraduate Students Trevor Schmitt Brendon Green

Previous Students Josette ElZaklit --- PhD student Biomedical Engineering at UNR Iain Hill --- Undergraduate student at UNR Dr. Pablo Castello --- Visiting Scientist from CONICET, Buenos Aires, Argentina Steven Schwades --- Master’s student in Mechanical Engineering at UNR Syed Nazmul --- Master’s student in Mechanical Engineering

Thesis: Tuning band-gaps of phononic crystals by external electromagnetic fields Nima Ghafoorianfar --- Post doc in Mechanical Engineering ---

Project: Microcontinuum phononic crystals

SYNERGISTIC ACTIVITIESBroadening participation of underrepresented groups 1. Membership committed to Society of Hispanic Professional Engineers (SHPE). The mission of SHPE is to

changes lives by empowering the Hispanic community to realize its fullest potential and to impact the world through STEM awareness, access, support and development.

2. PI is committed to incorporating minority and underrepresented students into Academic Research and Engineering by contracting Female/Hispanic Graduate Student.

Innovations in teaching and training3. The PI has developed and taught at the graduate level specialized topics fusing applied mechanics with

electrodynamics. The PI plans to continue this approach by organizing courses in magneto-biology focusing on quantum biology.

Collaborators and Other Affiliations Collaborators and Co-EditorsMargaret Ahmad (University of Paris VI, France) Jukka Juutilainen (University of Eastern Finland)Robert Usselman (Montana State University) Maria Procopio (Johns Hopkins University)Pablo Castello (University Belgrano, Argentina) Ilia Soloy’yov (University of Southern Denmark)

Graduate Adviser and Postdoctoral SponsorsPostdoctoral Advisor: Distinguished Professor Frank Barnes, University of Colorado BoulderPostdoctoral Advisor: Associate Professor Thorsten Ritz, University of California Irvine

Thesis AdviserPhD Dissertation Advisors: Distinguished Professor Frank Barnes, University of Colorado BoulderAssistant Professor Virginia Ferguson, University of Colorado Boulder

Thesis Adviser and Postgraduate Scholar Sponsors over the last 5 YearsTotal Number of Graduate Students Advised: 9

GRANTSFunded2017-2020Quantum Coherence in Reactive Oxygen Species BiologyAir Force Office Scientific Research --- $945,000Co-PI: Carlos F Martino

2017-2020Are current therapies addressing the disabilities of osteogenesis imperfecta effectively?NSFSub-Award: Carlos F Martino ---~$125,000

2015-2017Quantum biology of low frequency magnetic fields: cryptochromes, radicals, and genomic instabilityFinland Academy of ScienceCo-PI: Carlos F Martino

2014-2017Cryptochromes and their role in magnetic signal transductionAir Force Office of Scientific Research --- $2MPI: Thorsten Ritz, University of California Irvine, Co-PI: Margaret Ahmad, University of Paris VICo-PI: Carlos Martino ~ $290,000

PUBLICATIONS2017Blue-light induced biosynthesis of ROS contributes to the signaling mechanism of Arabidopsis cryptochrome. Mohamed El-Esawi, Louis-David Arthaut, Nathalie Jourdan, Alain d’Harlingue, Justin Link, Carlos F. Martino, and Margaret Ahmad. Accepted Scientific Reports.

Direction-dependent effects of combined static and ELF magnetic fields on cell proliferation and superoxide radical production Jonne Naarala, Kavindra Kumar Kesari, Ian McClure, Cristina Chavarriaga, Jukka

Juutilainen, Carlos F Martino. 2017. BioMed Research International 2017:5675086.

Blue-light induced accumulation of Reactive Oxygen Species is a consequence of the Drosophila cryptochrome photocycle Louis-David Arthaut, Nathalie Jourdan, Ali Mteyrek, Maria Procopio, Mohamed El-Esawi,

Alain d’Harlingue, Pierre-Etienne Bouchet, Thorsten Ritz, Andre Klarsfeld, Serge Birmann, Ute Hoecker, Carlos F Martino and Margaret Ahmad. 2017. PloS One Mar 15;12(3):e0171836

2016The Quantum Biology of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergetics.Robert J. Usselman, Christina Chavarriaga, Pablo R. Castello, Maria Procopio, Thorsten Ritz, Edward A. Dratz, David J. Singel, Carlos F. Martino.  2016. Scientific Reports 6, Article number: 38543

2015Blue-light dependent ROS formation by Arabidopsis cryptochrome may define a novel evolutionarily conserved signaling mechanismLaurent Consentino, Stefan Lambert, Carlos Martino, Nathalie Jourdan, Pierre-Etienne Bouchet, Jacques Witczak ,

Pablo Castello, Mohamed El-Esawi, Francoise Corbineau, Alain D’Harlingue and Margaret AhmadNew Phytol. 2015 Jun;206(4):1450-62. doi: 10.1111/nph.13341. Epub 2015 Feb 26.

Blue-light dependent ROS formation by cryptochrome may represent a novel signaling mechanism. Nathalie Jourdan, Carlos F Martino, Mohamed El-Esawi, Jacques Witczak,Pierre-Etienne Bouchet, Alain d'Harlingue & Margaret Ahmad. 2015. Plant Signaling & Behavior, 10:8, e1042647

2014Spin biochemistry modulates reactive oxygen species production by radio frequency magnetic fieldsRobert Usselman, Iain Hill, David Singe, Carlos F MartinoPLoS ONE 9(3): e93065. doi:10.1371/journal.pone.0093065

Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fieldsPablo Castello, Lucas Portelli, Robert Usselman, Frank Barnes, Carlos F Martino

2012Reduction of the Earth’s Magnetic Field Inhibits Drosophila Melanogaster Ability to Survive Ionizing RadiationLucas Portelli, Dinu Madapatha, Sabrina Renteria, Carlos F Martino, Frank Barnes Bioelectromagnetics

2011Modulation of hydrogen peroxide production in cellular systems by low level magnetic fields Carlos F Martino, Pablo CastelloPLoS ONE 6(8)

Static magnetic field sensitivity of endothelial cellsCarlos F MartinoBioelectromagnetics 32(6): 506-508

2010Reduction of the Earth’s magnetic field inhibits growth rates of cancer cells Carlos F Martino, Lucas Portelli, Kevin McCabe, Mark Hernandez, Frank Barnes. Bioelectromagnetics 31(8): 649-655

Effects of weak static magnetic fields on endothelial cellsCarlos F Martino, Héctor Perea, Ursula Hopfner, Virginia Ferguson, Erich Wintermantel.Bioelectromagnetics 31(4): 296-301.

2008The effects of pulsed electromagnetic fields on cellular activity of SaOS-2 cells Carlos F Martino, Dmitry Belchenko, Virginia Ferguson, Sheila Preiss, Jerry H Qi Bioelectromagnetics 29(2): 125-132.

Mode-selective acoustic spectroscopy of trigonal crystalWard Johnson, Carlos F Martino, Sudook Kim, Paul HeyligerUltrasonics, Ferroelectrics, and Frequency Control 55(5): 133-1142.

PRESENTATIONS

2017Invited TalkQuantum Biology of Reactive Oxygen Species and its Impact in Cellular BioenergeticsQuantum Life Science Conference, Chiba, Japan

2016Quantum Biology of Reactive Oxygen Species. Carlos F MartinoQuantum Biology Conference, Durban, South Africa

2015Quantum physics and the aging process - the effect of weak magnetic fields on regulating the levels of ROS in living mammalian cellsCarlos F MartinoInvited talk University of Paris VI, Paris, France

Spin biochemistry regulates reactive oxygen species production by radio frequency magnetic fieldsBioelectromagnetics Society June 14-19Carlos F Martino, Robert Usselman

Effects of weak 7 MHz magnetic fields on reactive oxygen species in vitroRobert J. Usselman, Pablo Castello, and Carlos F. MartinoPIERS 2015, Prague, Czech Republic July 4-9

2013Modulation of cellular and mitochondrial reactive oxygen species by magnetic fieldsPablo Castello, Josette Zaklit, Robert Usselman, Carlos F MartinoBioelectromagnetics Society Meeting, Thessaloniki, Greece, June 2013

Cryptochrome-dependent magnetic sensitivity of Arabidopsis thaliana is maximal in the geomagnetic range and occurs by a radical pair mechanismCarlos F Martino, Thorsten Ritz, Margaret AhmadBioelectromagnetics Society Meeting, Thessaloniki, Greece, June 2013

2012Differential effects of magnetic field in biological systems in vitro and in vivoCarlos F Martino, Lucas Portelli, Frank BarnesBioelectromagnetics Society Meeting, Brisbane, Australia, June 2012

Modulation of reactive oxygen species by low level fields in cellular systemsCarlos F Martino, Pablo CastelloExperimental Biology, San Diego, April 2012

2010Low-level magnetic fields inhibit growth rates of cancer cellsCarlos F Martino, Lucas Portelli, Frank BarnesGordon Research Conference, Bioelectrochemistry, July 11-16 2010

Reduction of the Earth’s magnetic field below background levels inhibit growth rates of cancer cellsCarlos F Martino, Lucas Portelli, Frank BarnesBioelectromagnetics Society Meeting, Seoul, S Korea, June 2010

2009Weak Magnetic Fields Inhibit Growth Rates of Cancer Cell LinesCarlos F Martino, Lucas Portelli, Frank BarnesButcher Symposium, Westminster, CO

2007Biological Systems: Do Magnetic Fields Matter?Carlos F Martino, Virginia Ferguson, Jerry H. QiGraduate Engineering Annual Research Symposium, Boulder Colorado

Use of Static Magnetic Stimulation to Promote Endothelium Recovery and FunctionCarlos F Martino, Héctor Perea, Ursula Hopfer, Erich Wintermantel Tissue Engineering, Tokyo Japan

2006Interaction of Weak Static Magnetic Fields and Endothelial CellsCarlos F Martino, Héctor Perea, Ursula Hopfer, Jerry H Qi, Erich Wintermantel3rd Annual Erice School on Mechanisms of Interaction between Electromagnetic Fields and Biological Systems Poster Session, Erice Italy Electromagnetic Field Effects on Biological SystemsCarlos F Martino, Jerry H QiInvited presentation to Orthopädische Klinik der Universität Regensburg, Regensburg Germany

The Effects of Pulsed Electromagnetic Fields on Cellular Activity of Osteoblast-like Cells Carlos F Martino, Jerry H QiInvited “Hot Topics Session”, Gordon Research Conference-Bioelectrochemistry, Modane France

Comparison of Waveform on the Response of SaOS-2 Cells Carlos F Martino, Jerry H Qi Gordon Research Conference-Bioelectrochemistry Poster Session, Modane France

Effects of Pulsed Electromagnetic Fields on Cellular Activity of Osteoblast-like CellsCarlos F Martino, Dmitry Belchenko, Virginia Ferguson, Sheila Preiss, Jerry H Qi28th Annual Bioelectromagnetic Society Poster Session, Cancun Mexico

2005Electromagnetic fields in cellular response of osteoblasts-like cellsCarlos F Martino, Dmitry Belchenko, Virginia Ferguson, Sheila Preiss, Jerry H Qi University of Colorado-Denver Mathematics Department

SaOS-2 Response to Pulsed Electromagnetic FieldsCarlos F Martino, Sheila Preiss, Jerry H QiUniversity of Colorado Health Science Systems, Denver Colorado

Mode-selective Acoustic Spectroscopy of Trigonal CrystalsCarlos F Martino, Ward JohnsonGraduate Engineering Annual Research Symposium, Boulder Colorado