† trademark of merck & co., inc., whitehouse station, nj, usa invanz ™† (ertapenem) updated...

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  • Slide 1
  • Trademark of Merck & Co., Inc., Whitehouse Station, NJ, USA INVANZ (ertapenem) Updated Results in Complicated Intra-abdominal Infections
  • Slide 2
  • 2 Yellin AE et al. Int J Antimicrob Agents 2002;20:165-173. Solomkin JS et al. Ann Surg 2003;237:235-245. Pacelli P et al. Arch Surg 1996;131:641-645. The Clinical Impact of Intra-abdominal Infection (IAI) Intra-abdominal infections are among the most common infections in general surgery. Surgery, supportive care, and antibiotic therapy are key in managing IAI. In a retrospective study of 604 patients, morbidity rates of 59% and mortality rates of 21% were reported. IAI is a major cause of morbidity and mortality.
  • Slide 3
  • 3 Treatment of patients for IAI is costly worldwide. 1. Walters DJ et al. Pharmacoeconomics 1999;16(5):551-561. 2. Attanasio E et al. Dig Surg 2000;17:164-172. 3. Cattan P et al. Eur J Clin Microbiol Infect Dis 2002;21:787-793. 4. Davey P et al. Presented at the International Society of Pharmacoeconomics and Outcomes Research Sixth Annual International Meeting, 2001. 5. Lyu R et al. Presented at the 10 th International Congress of Infectious Disease, 2002. The Economic Burden of IAI US: USD$7678 to USD$12,523 per patient 1 Italy: 1859 to 2324 per patient 2* France: 4625 to 15,548 per patient 3 Scotland: 4190 to 7705 sterling per patient 4 Australia: AUS$5053 to AUS$5316 per patient 5 *Converted from Lira at the exchange rate on 10 March 2000, where 3.6 million Lira = 1859 and 4.5 million Lira = 2324.
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  • 4 Yellin AE et al. Int J Antimicrob Agents 2002;20:165-173. Solomkin JS et al. Ann Surg 2003;237:235-245. Mazuski JE et al. Surg Infect 2002;3:161-173. Fry DE. Surg Infect 2001;2(Suppl 1):S3-S11. Appropriate Antibiotic Therapy for IAI Antibiotic therapy is an important adjunct to surgery and supportive therapy. Antibiotic treatment should cover appropriate gram- positive and gram-negative, aerobic and anaerobic bacteria. Most of the available antibiotics for the treatment of IAI generally require multiple daily doses or combination multidrug therapy to provide adequate coverage of all important pathogens.
  • Slide 5
  • 5 Considerations in determining appropriate therapy: Raymond DP et al. Surg Infect 2002;3:375-385. Moellering RM. In: GL Mandell, JE Bennett, R Dolin, eds. Principles and Practice of Infectious Diseases, 5th ed, 2000. Fry DE. Surg Infect 2001;2:S3-S11. Defining Appropriate Therapy Spectrum of activity Timing of therapy Dose and dosing frequency Drug interactions and tolerability Adequate drug levels Prior antibiotic treatment Potential for engendering antibiotic resistance
  • Slide 6
  • 6 Possible Outcomes of Appropriate Therapy Improved chance of successful clinical outcome Reduced mortality Probable decrease in need for re-operation and second-line therapy Probable reduction in number of IV antibiotic days Possible decrease in length of hospital stay Probable reduction in hospital costs
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  • 7 p

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