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Inflammation visualization

www.smart-thermograph.com

SMA®T THERMOGRAPH

Cold? Sinusitis? Arthritis? Other inflammation?

What is your choice on a shelf in mall or pharmacy?

OR +



The main marketArthritis is the most commoncause of disability adults for thepast 15 years globally and costs$128 bln a year.

45000000

50000000

55000000

60000000

65000000

70000000

2000 2005 2010 2015 2020 2025 2030 2035

Adults with doctor diagnosed arthritis in U.S.

67.5%

12.9%

9.8%

Adults (18-65) arthritis distribution

Low risk Have diagnosed arthritis Have life&work limitations

http://www.cdc.gov/arthritis/data_statistics/arthritis_related_stats.htm

There is no efficient home device solution for arthritis monitoring on

the market



Market gap - opportunity

Hypertonia

Diabetes Arthritis

Sm

art

Th

erm

og

rap

h

Medical self-care devices & mHealth market



The product – sample package

Local temperature increase is a well-known sign of arthritis, sinusitis and

other inflammatory sicknesses of organs close to the skin surface.

(Clinical study can be found here in Appendix 1 )



The product

Smart Thermograph device with Bluetooth LE

Source of raw data

Free application for iPhone, Android or Windows

User interface

Data interpretation

Web service Data storage

Integration with other services

Data analysis & sharing

Retail price ~$59



The product

Patented medical intelligent inflammation monitoring device for home use

Provide treatment monitoring of inflammation accompanying arthritis and 100+ inflammatory diseases of organs close to skin surface

Treatment efficiency thermo monitoring of inflammation

Lifestyle correction to prolong time to disability

Build precise and medically correct thermograms

Measure surface temperature at any area of a body

Adds value to the standard medical body thermometer by novel but easy to understand and highly demanded functions

IR thermometers with “Surface temperature” function are FDA/CE approved

Existing on the market business model is used



Target audience

The product is intended for more than 50% of global population:

• People who suffer from one or several of 100+ chronic

inflammation diseases (Arthritis, Phlebitis, Pulpitis, Lymphadenitis,

Dermatitis, Sinusitis, Laryngitis, Tracheitis, Mastitis, Myositis, Prostatitis, Post Injection

Inflammation, etc.).

• People after trauma

Helps to solve “quality of life” problem for people with arthritis by:

• Promotion of treatment efficiency

• Finding correct zone to rub gels and apply other local treatment

• Lifestyle correction



Chronical inflammation sicknesses

First chronical inflammation

sickness diagnosed by a

doctor

35•Development of the first and appearance of others sicknesses

•Lifestyle is getting worse

•Active search of solutions

45•Sicknesses are developed

•Less active search for solutions

70

Best point for salesMinimal salesMinimal sales



Conservative market volume estimation

Device Targetglobal population (%)

Device sales volume (est.)

Total market (per year)

Conversion (without device replacement)

Glucometer 10% 60 mln per year

$6 bln 20%

Tonometer 35% 15 mln per year

$1.5 bln 1.5%

Smart Thermograph

20% 60 mln per year

$3.6 bln 10%

Glukometer

52%Tonometer

13%

Smart

Thermograph31%

Others

4%

Estimation

Source: IHS



Market goals

Conventional thermometers

Tonometers

Glukometers

Others

MARKET SHARES

Conventional thermometers

Tonometers

Glukometers

Others

Smart Thermograph -new niche

MARKET SHARES (GOAL)

Goal:

• Create a new niche of home inflammation monitoring devices with full patent monopoly in it

Method:

• Using existing distribution & production chains introduce the standard thermometer with

unique thermograph features



Business modelSmart Thermograph LTD

• Owns and manages

intellectual property

(patents, trade marks)

• Manages production,

manages development

of hardware and

software

• Certification support

for distributors

Regional distributor

• Manages certification,

sales and support in

the region

Smart Thermograph LTDContractor

Product liability

Regional distributor

Regional certification

organization

Distributor may not have any marketing budget as it

uses standard available sales channels

Mall Pharmacy

Distribution agreement

Online

Third-party apps



Success history

Personal blood pressure monitoring market “Hypertension is estimated to affect 43 to 56 million adults or

24% to 31% of the US population and is emerging as a major

health problem in some countries in the Third World.1-

3 Hypertension contributes to all the major atherosclerotic

cardiovascular disease outcomes.”

“Consumers generally prefer machines with digital readouts and

are purchasing an increasing number of electronic HBP monitors

(Eric Vennemeyer, written communication, December 10,

1997).24 Sales of electronic monitors have increased from

57% of the world market in 1992 to 58% in 1995 and are

expected to increase to 68% in 2002.”

http://archinte.jamanetwork.com/article.aspx?articleid=485316

http://archinte.jamanetwork.com/article.aspx?articleid=485316#ref-ira90023-1





WE INVITE DISTRIBUTORS

RECOMMENDED RETAIL PRICE $59



MARKETING DETAILS

Appendix 1



Market volumes

Smart Thermograph –

solution for monitoring

• Chronic inflammatory

diseases organs close

to skin surface

(arthritis, sinusitis,

phlebitis, myositis etc.)

• Independent aging

(arthritis – major

reason for restricting

ability to move)



Applicable sicknesses

The Smart Thermograph is intended for thermo monitoring of inflammation skin and organs located near skin:

Dermatitis, eczema, abscess, furuncle, carbuncle, cellulitis, arthritis and

polyarthritis, periarthritis, tendinitis, bursitis, epicondylitis, fasciitis,

pulpitis, osteitis, synovitis, tenosynovitis, periostitis, sialoadenitis,

lymphadenitis, thyroiditis, otitis, mastoiditis, sinusitis, laryngitis,

tracheitis, tonsillitis, mastitis, phlebitis, thrombophlebitis, angiitis,

lymphangitis, polymyositis, myositis, prostatitis, injury etc.

Smart Thermograph is not intended for diagnostics of any diseases and not intended for thermo monitoring of inflammation diseases of organs located deeply in regard to skin surface (e.g. nephritis, pyelonephritis, gastritis, colitis, pancreatitis, cholecystitis, encephalitis etc.).

You may find complete clinical research in top world medical magazines here

http://smart-thermograph.com/wp-content/uploads/2014/12/Medical_Review.doc





Smart Thermograph is the cheapest and efficient technology ever

Thermograph

IR CCD\CMOS matrix

Provides instant thermogramm

Impossible to compare results for monitoring

Not applicable for curved body areas*

Applicable in professional setup

Smart Thermograph

Single sensor

Takes 1 sec to measure1 point*

Automatically compare results for monitoring

Applicable for all body areas

Applicable at home

* For the details please refer to the movie for experts on the site http://www.smart-thermograph.com



Thermometer is the simplest tool for inflammation thermo monitoring.

Thermometer measures the overall body temperature to assess the common

inflammation of the body.

However, it is insufficient for revealing of local thermo signs of

inflammation diseases, visualization, estimation of the effectiveness of

therapy, thermo monitoring of diseases.

Smart Thermograph provides visualization of inflamed area and

intelligent treatment thermo monitoring.

Thermometer



The most popularhome medical

device

Diseases for monitoring

Visualization of the health

problem

Measurement accuracy

Automatic interpretati

on

Educational market barriers

Patent protection

Automatic tonometer

Hypertension Hypotension

No Satisfactory No Medium No

Electronic glucometer

Diabetes No Satisfactory No Medium No

Conventional thermometer

Inflammatory diseases/non-specifically

No Satisfactory No Low No

Smart Thermograph

Inflammatory diseases/local thermosigns(100+ diseases)

Yes Satisfactory Yes MediumYes

(up to 2029)

Comparison with similar products



Application comparison for inflammation sicknesses

Child Adult Senior

Body temperature reactivity

High Moderate Low

Local temperature reactivity

High High High

Standard (body) thermometer efficiency

High Moderate Low

Smart Thermograph efficiency

High High High

Smart Thermograph is

efficient for all ages



Usage scenario

Inflammationsickness

diagnosed

First thermomonitoring

session

Gel applied or medicine

taken

Some other treatment activities conducted

All subsequent thermo

monitoring sessions

Visual and digital dynamics of inflammation thermosigns

Objective treatment efficiency monitoring

• Objective thermo signs of inflammation

• Dimensions of inflamed area

• Precise location for local therapy

Negative

or

Positive

dynamics

Negative

or

Positive

dynamics

Diagnose is conducted only by a doctor.

This requirement is stated in the product

manual

Smart Thermograph boundaries



Smart Thermograph advantages in accuracy

• Single value

• Incorrect position

• Shaking hands

Low precision

• Multiple spatial measurements

• Tolerant to positioning errors

• Averages measurements

Higher accuracy



Technical details

Smart Thermograph method is a visualization method of temperature fields of a biological object skin surface providing medically correct distribution of the temperature.

Special grid of points allows unrevealing of temperature gradient between the measurement points and identify areas of relative normo-, hypo-, hyperthermia of measured area.

For inflammation sicknesses areas of hyperthermia are relevant. Color visualization provides a handy way to analyze inflammation process.

During inflammation of skin surface and organs placed close to skin surface temperature of inflamed area is increased\decreased depending on the dynamics of inflammation process. Those trends are automatically being interpreted by software service.



Umbrella EU patent claim

1. A method of displaying a temperature field of a biological object, the method comprising the steps of:

obtaining temperature measurements of an area of a biological object;

obtaining an image of the area of the biological object;

generating an image of a temperature field of the area of the biological object and superimposing the image of the temperature field on the image of the area of the biological object;

displaying the superimposed image of the temperature field on the image of the area of the biological object on a computer screen, wherein an area of the biological object is an area of human skin surface;

an image of the area of the biological object is a photographic image of the area of the human skin surface; characterized in that:

before the temperature measurements are obtained:

obtaining and displaying on the computer screen a photographic image of the area of the human skin surface;

marking points by graphic indications on the photographic image displayed on the computer screen, the points marked by graphic indications on the photographic image correspond to the points on the area of the human skin surface on which measurements of temperature will take place;

displaying on the computer screen a photographic image with marked graphic indications of points marked on it; herewith obtaining temperature measurements by infrared thermometer or infrared pyrometer consistently at the points of the area of the human skin surface in correspondence with the points marked by graphic indications on the photographic image, wherein temperature measurements are obtained by an infrared thermometer or an infrared pyrometer.

2. The method of claim 1, wherein the temperature field of the area of the human skin surface is formed by interpolation of temperatures, measured at the measurement points on the area of the human skin surface.

3. The method of claim 2, wherein the temperature field of the area of the human skin surface is formed by linear interpolation of temperatures, measured in adjacent measurement points on the area of the human skin surface.

4. The method of claim 2, wherein the image of the temperature 5 field of the area of the human skin surface is displayed on the computer screen in accordance with a computer program color palette, in which each specific color corresponds to a temperature value.

5. The method of claim 1, wherein the temperature measurements are displayed in a numerical form on the screen of the computer at the corresponding measurement points on the image of the area of the human skin surface.

6. The method according to any previous claim, wherein the temperature measurements are obtained serially.

7. The method according to any previous claim further comprising the step of saving the temperature field in a database.

8. The method according to any previous claim, wherein each point where a temperature measurement is to be taken is displayed on the image sequentially following a temperature measurement of a previous point.

9. A computer program comprising program instructions that, when executed on a computer cause the computer to perform the method of any of claims 1 to 8.

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