الرحمن الله بسمالرحيم

الرحمن الله بسمالرحيم

Part 1Part 1

Isthmus

Pyramidal lobe

Right lobe Left lobe

Ciliary bodyChoroid plexusSalivary glandMammary glandGastric mucosa

Placenta

proteins

enzymes

Mechanism of Action Mechanism of Action

Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs

I – Effects on Metabolism .

I - 1 . Cell Metabolic activity . a – Mitochondria : # & size .

b – Cell membrane ions transport : stimulation of Na / K pump .

Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs

I - 2 . Body metabolic processes .

a – Carbohydrate metabolism : increased =

glucose absorption by GIT , insulin secretion & uptake by cell : glycolysis , gluconeogenesis . b – Fat metabolism : Increased FA oxidation & depletion of fat stores c – Plasma lipids : decrease plasma cholestrol : increased secretion in bile & stools . Increased # of liver LDL receptors .

Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs

I - 2 . Body metabolic processes .

a – Carbohydrate metabolism : increased =

glucose absorption by GIT , insulin secretion & uptake by cell : glycolysis , gluconeogenesis . b – Fat metabolism : Increased FA oxidation & depletion of fat stores c – Plasma lipids : decrease plasma cholestrol : increased secretion in bile & stools . Increased # of liver LDL receptors . d – Basal Metabolic Rate : BMR : BEE = normal body wt .

Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs

II – Effects on Growth . a - Growth & Development of brain . b - Skeletal growth .

III – Effects on body systems . a – Primary effect . b – Secondary effect .

Stimulate O2 consumption : GIT , endocrine , Respiratory , CVS , …..

Except anterior pituitary , adult brain , testes, uterus, lymph nodes & spleen

Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs

Except

anterior pituitary adult brain testes, uterus, lymph nodes & spleen

TSH

Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs

II – Effects on Growth . a - Growth & Development of brain . b - Skeletal growth .

III – Effects on body systems . a – Primary effect .

b – Secondary effect .

CVS : Heart :

Chronotropic : Increased # & affinity of adr. receptors

Inotropic : Enhance response to circulating catecholamines Increased atrial MHC with more ATPase activity .

TRH

TSH

T4

T3Tissues

TSH