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EOSINOPHIL NEWS

INTERNATIONAL EOSINOPHIL SOCIETY, INC. WINTER 2014

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Message from the PresidentDear colleagues and friends,

Time runs fast and we would like to update you with a newsletter about recent developments in our society as well as in our field of research. For instance, you will find information about the upcoming biennial meeting to be held in July next year in downtown Chicago kindly summarized by the meeting organizer Bruce Bochner. You are also informed about a recently established multicenter consortium on eosinophilic disorders that received a 5-year, $6.25 million NIH grant. Congratulations to Marc Rothenberg, Glenn Furuta, and the other involved principal investigators of the consortium - this is great news for the researcher in this field. Moreover, our young investigator group provides you with an IES trainee update. This newsletter also contains a list of selected studies that have recently been published and we hope that this service will be appreciated by our members.

Finally, I am happy to inform you that Marie Carlson and Christine Wennerås will be the organizers of the 2017 IES symposium which will be held in Gothenburg, Sweden. We currently collect applications for 2019 and would like to encourage you to send us your application until June 30, 2015.

I would like to take the opportunity to wish you all the best for the upcoming holiday season.

Sincerely,

Hans-Uwe Simon, MD PhDPresident

Planning for the July 2015 IESBruce S. Bochner, MD, 2015 IES Scientific Program DirectorNovember 2014

Dear Colleagues-

Planning for the July 2015 IES meeting is now in full swing. Our NIH grant application requesting travel grant support for trainees, which we have successfully received in the past, has kindly been written by Dr. Steve Ackerman and already submitted by our able IES meeting staff. Conference calls have been arranged for the Organizing Committee to begin discussing specific details for the meeting, and the Fundraising Committee will also soon begin their efforts in ernest. We are delighted to hear of exciting progress being made in clinical trails with a range of novel eosinophil-active biologicals for the treatment of asthma, atopic

dermatitis, eosinophilic gastrointestinal disorders and others, and hope to showcase these advances at our meeting. And besides the clinical and basic science presentations, we are working on offering nearby fun, interesting and affordable event options for your free time to make the meeting as enjoyable as possible. By the time of the next quarterly newsletter, we should be able to begin providing additional specifics, so for now, please save the date if you have not already done so.


International Eosinophil Society, Inc.

9th Biennial Symposium

14-18 July 2015Chicago, IL

Holiday Inn Mart Plaza

AS AN IES MEMBER, YOU ARE ENTITLED TO THE FOLLOWING MEMBERSHIP BENEFITS:

• Access to the "Members Only" section of the website including:

- Membership Directory - Abstract books from the 2011 and 2013 Biennial Symposia - Photo gallery from the 2011 and 2013 Biennial Symposia - Eosinophil research aids• Reduced Biennial Symposium registration rates (In order to

receive the reduced membership rate, members must be in good standing for at least two years.)

• Participation in a variety of committees

During the past 12 years, the biennial meetings of the IES have consistently provided an exciting venue for interactions between scientists and clinicians studying eosinophils and eosinophilic disorders. In order to continue to do so, the IES needs your support.

In order to better facilitate our member’s needs, we have transitioned to two-year dues. Trainee members still have the option of selecting one-year or two-year dues. We hope that you will consider renewing your membership for 2015-2016. Watch for the dues announcement coming soon.


Eosinophils in Health and DiseaseEdited By James J. Lee and Helene F. Rosenberg

Key Features:• The only updated, comprehensive source of information on

eosinophils currently available• Presents a holistic view of the subject, including basic science,

disease-specific chapters, therapeutic options and emerging areas of research

• Features content from over 100 authors who are prominent members of the eosinophil research and clinical community

• Includes detailed illustrations, figures and tables

More details available online atwww.eosinophil-society.org/eosinophil-resources/iespublications

World Allergy Organization International Scientific Conference 2014 (WISC 2014)6-9 December 2014Rio de Janeiro, Brazil

American Society of Hematology6-9 December 2014San Francisco, CA

AAAAI Annual Meeting20-24 February 2015Houston, TX

British Society for Haematology20 - 22 April 2015Edinburgh, United Kingdom

American Thoracic Society15 - 20 May 2015Denver, CO

EAACI Congress 20146 - 10 June 2015Barcelona, Spain

European Hematology Association11 - 14 June 2015Vienna, Austria

Federation of Clinical Immunology Societies (FOCIS)22 - 28 June 2015San Diego, CA

9th Biennial Symposium of the International Eosinophil Society, Inc.13-19 July 2015Chicago, IL

CALENDAR OF EOSINOPHILIC EVENTS


Kottyan, Leah C., Benjamin P. Davis, Joseph D. Sherrill, Kan Liu, Mark Rochman, Kenneth Kaufman, Matthew T. Weirauch et al. “Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.” Nature Genetics DOI: 10.1038/ng.3033 (2014).

Caldwell, Julie M., Margaret H. Collins, Emily M. Stucke, Philip E. Putnam, James P. Franciosi, Jonathan P. Kushner, J. Pablo Abonia, and Marc E. Rothenberg. “Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome.” Journal of Allergy and Clinical Immunology (2014).

Alexander, Eileen S., Lisa J. Martin, Margaret H. Collins, Leah C. Kottyan, Heidi Sucharew, Hua He, Vincent A. Mukkada et al. “Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis.” Journal of Allergy and Clinical Immunology (2014).

Cugno M, Marzano AV, Lorini M, Carbonelli V, Tedeschi A. “Enhanced Tissue Factor Expression by Blood Eosinophils from Patients with Hypereosinophilia: A Possible Link with Thrombosis.” PLOS ONE 9.11 (2014): e111862.

Capocelli KE, Fernando SD, Menard-Katcher C, Furuta GT, Masterson JC, Wartchow EP. “Ultrastructural features of eosinophilic oesophagitis: impact of treatment on desmosomes.” Journal of Clinical Pathology. 2014 Oct 30. pii: jclinpath-2014-202586. doi: 10.1136/jclinpath-2014-202586. [Epub ahead of print]

Elmose C, Sverrild A, van der Sluis S, Kyvik KO, Backer V, Thomsen SF. “Genetic factors explain half of all variance in serum eosinophil cationic protein.” Clinical & Experimental Allergy. 2014 Oct 29. doi: 10.1111/cea.12445. [Epub ahead of print]

Odemuyiwa SO, Ilarraza R, Davoine F, Logan MR, Shayeganpour A, Wu Y, Majaesic C, Adamko DJ, Moqbel R, Lacy P. “Cyclin-Dependent Kinase 5 Regulates Degranulation in Human Eosinophils.” Immunology. 2014 Oct 26. doi: 10.1111/imm.12416. [Epub ahead of print]

Radonjic-Hoesli S, Valent P, Klion AD, Wechsler ME, Simon HU. “Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy.” Annual Review of Pharmacology and Toxicology. 2014 Oct 17. [Epub ahead of print]

Jiang P, Wang DZ, Ren YL, Cai JP, Chen BX. „Significance of eosinophil accumulation in the thrombus and decrease in peripheral blood in patients with acute coronary syndrome.“Coronary Artery Disease. 2014 Oct 21. [Epub ahead of print]

Gordy C, Liang J, Pua H, He YW. “c-FLIP Protects Eosinophils from TNF-α-Mediated Cell Death In Vivo.” PLoS One. 2014 Oct 21;9(10):e107724. doi: 10.1371/journal.pone.0107724. eCollection 2014.

Min A, Lee YA, Kim KA, El-Benna J, Shin MH. “NOX2-Derived ROS-Mediated Surface Translocation of BLT1 Is Essential for Exocytosis in Human Eosinophils Induced by LTB4.” International archives of allergy and immunology. 2014 Oct 15;165(1):40-51. [Epub ahead of print]

Brannan JD, Bood J, Alkhabaz A, Balgoma D, Otis J, Delin I, Dahlén B, Wheelock CE, Nair P, Dahlén SE, O’Byrne PM. “The effect of omega-3 fatty acids on bronchial hyperresponsiveness, sputum eosinophilia and mast cell mediators in asthma.” CHEST Journal. 2014 Oct 16. doi: 10.1378/chest.14-1214. [Epub ahead of print]

Takeda K, Shiraishi Y, Ashino S, Han J, Jia Y, Wang M, Lee NA, Lee JJ, Gelfand EW. “Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge.” Journal of Allergy and Clinical Immunology. 2014 Oct 10. pii: S0091-6749(14)01186-5. doi: 10.1016/j.jaci.2014.08.014. [Epub ahead of print]

Castro M, Wenzel SE, Bleecker ER, Pizzichini E, Kuna P, Busse WW, Gossage DL, Ward CK, Wu Y, Wang B, Khatry DB, van der Merwe R, Kolbeck R, Molfino NA, Raible DG. “Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study.” The Lancet Respiratory Medicine. 2014 Oct 8. pii: S2213-2600(14)70201-2. doi: 10.1016/S2213-2600(14)70201-2. [Epub ahead of print]

HOT OFF THE PRESS


Jhun BW, Kim SJ, Kim K, Lee JE, Hong DJ. „Clinical implications of correlation between peripheral eosinophil count and serum levels of IL-5 and tryptase in acute eosinophilic pneumonia.“ Respiratory Medicine. 2014 Sep 30. pii: S0954-6111(14)00322-9. doi: 10.1016/j.rmed.2014.09.011. [Epub ahead of print]

Wong D, Winter O, Hartig C, Siebels S, Szyska M, Tiburzy B, Meng L, Kulkarni U, Fähnrich A, Bommert K, Bargou R, Berek C, Chu VT, Bogen B, Jundt F, Manz RA. “Eosinophils and Megakaryocytes Support the Early Growth of Murine MOPC315 Myeloma Cells in Their Bone Marrow Niches.” PLoS One. 2014 Oct 1;9(10):e109018. doi: 10.1371/journal.pone.0109018. eCollection 2014.

Salazar VA, Rubin J, Moussaoui M, Pulido D, Nogués MV, Venge P, Boix E. “Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms.” FEBS Journal. 2014 Sep 30. doi: 10.1111/febs.13082. [Epub ahead of print]

Makita N, Hizukuri Y, Yamashiro K, Murakawa M, Hayashi Y. “IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration.” International immunology. 2014 Sep 29. pii: dxu090. [Epub ahead of print]

Ponikau JU, Winter LA, Kephart GM, Squillace DL, Hershcovitch MD, Moon S, Sherris DA, Kern EB, Gleich GJ, Kita H. “An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein.” International forum of allergy & rhinology. 2014 Sep 29. doi: 10.1002/alr.21421. [Epub ahead of print]

Minai-Fleminger Y, Gangwar RS, Migalovich-Sheikhet H, Seaf M, Leibovici V, Hollander N, Feld M, Moses AE, Homey B, Levi-Schaffer F. “The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation.” Clinical & Experimental Allergy. 2014 Nov;44(11):1335-46. doi: 10.1111/cea.12422.

Messingham KN, Holahan HM, Frydman AS, Fullenkamp C, Srikantha R, Fairley JA. “Human Eosinophils Express the High Affinity IgE Receptor, FcεRI, in Bullous Pemphigoid.” PLoS One. 2014 Sep 25;9(9):e107725. doi: 10.1371/journal.pone.0107725. eCollection 2014.

Fulkerson PC, Schollaert KL, Bouffi C, Rothenberg ME. “IL-5 Triggers a Cooperative Cytokine Network That Promotes Eosinophil Precursor Maturation.” The Journal of Immunology. 2014 Oct 15;193(8):4043-52. doi: 10.4049/jimmunol.1400732. Epub 2014 Sep 17.

Rothenberg ME, Wen T, Greenberg A, Alpan O, Enav B, Hirano I, Nadeau K, Kaiser S, Peters T, Perez A, Jones I, Arm JP, Strieter RM, Sabo R, Gunawardena KA. “Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis.” Journal of Allergy and Clinical Immunology. 2014 Sep 13. pii: S0091-6749(14)01053-7. doi: 10.1016/j.jaci.2014.07.049. [Epub ahead of print]

Melo RC, Weller PF. “Unraveling the complexity of lipid body organelles in human eosinophils.” Journal of leukocyte biology. 2014 Nov;96(5):703-712. Epub 2014 Sep 10. Review.

Huang L, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Lee NA, Lee JJ, Appleton JA. „Eosinophil-derived IL-10 supports chronic nematode infection.“ The Journal of Immunology. 2014 Oct 15;193(8):4178-87. doi: 10.4049/jimmunol.1400852. Epub 2014 Sep 10.

Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT. “Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis.” Gut. 2014 Sep 10. pii: gutjnl-2014-306998. doi: 10.1136/gutjnl-2014-306998. [Epub ahead of print]

Brightling CE, Bleecker ER, Panettieri RA Jr, Bafadhel M, She D, Ward CK, Xu X, Birrell C, van der Merwe R. “Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study.” The Lancet Respiratory Medicine. 2014 Sep 5. pii: S2213-2600(14)70187-0. doi: 10.1016/S2213-2600(14)70187-0. [Epub ahead of print]

Tian BP, Hua W, Xia LX, Jin Y, Lan F, Lee JJ, Lee NA, Li W, Ying SM, Chen ZH, Shen HH. “Exogenous Interleukin-17A Inhibits Eosinophil Differentiation and Alleviates Allergic Airway Inflammation.” American journal of respiratory cell and molecular biology. 2014 Sep 2. [Epub ahead of print]

HOT OFF THE PRESS, CONTINUED


Cunha AA, Porto BN, Nuñez NK, Souza RG, Vargas MH, Silveira JS, Souza TT, Jaeger N, Pitrez PM. “Extracellular DNA traps in bronchoalveolar fluid from a murine eosinophilic pulmonary response.” Allergy. 2014 Dec;69(12):1696-700. doi: 10.1111/all.12507. Epub 2014 Sep 13.

Lee JJ, Protheroe CA, Luo H, Ochkur SI, Scott GD, Zellner KR, Raish RJ, Dahl MV, Vega ML, Conley O, Condjella RM, Kloeber JA, Neely JL, Patel YS, Maizer P, Mazzolini A, Fryer AD, Jacoby NW, Jacoby DB, Lee NA. “Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice.” Journal of Allergy and Clinical Immunology. 2014 Aug 13. pii: S0091-6749(14)00954-3. doi: 10.1016/j.jaci.2014.07.003. [Epub ahead of print]

Landolina NA, Levi-Schaffer F. “Eosinophils as a pharmacological target for the treatment of allergic diseases.” Current opinion in pharmacology. 2014 Aug;17C:71-80. doi: 10.1016/j.coph.2014.07.014. Epub 2014 Aug 14. Review.

Burnham ME, Esnault S, Roti Roti EC, Bates ME, Bertics PJ, Denlinger LC. “Cholesterol selectively regulates IL-5 induced mitogen activated protein kinase signaling in human eosinophils.” PLoS One. 2014 Aug 14;9(8):e103122. doi: 10.1371/journal.pone.0103122. eCollection 2014.

Dent G, Loweth SC, Hasan AM, Leslie FM. „Synergic production of neutrophil chemotactic activity by colonic epithelial cells and eosinophils.“ Immunobiology. 2014 Oct;219(10):793-7. doi: 10.1016/j.imbio.2014.06.008. Epub 2014 Jul 23.

Felton JM, Lucas CD, Rossi AG, Dransfield I. “Eosinophils in the lung - modulating apoptosis and efferocytosis in airway inflammation.” Frontiers in immunology. 2014 Jul 1;5:302. doi: 10.3389/fimmu.2014.00302. eCollection 2014. Review.

Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A, Shen P, Gordon ME, Barra NG, Bassett JD, Kong J, Fattouh R, McCoy KD, Bowdish DM, Erjefält JS, Pabst O, Humbles AA, Kolbeck R, Waserman S, Jordana M. “Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.” The Journal of experimental medicine. 2014 Jul 28;211(8):1657-72. doi: 10.1084/jem.20131800.

Jung Y, Rothenberg ME. “Roles and regulation of gastrointestinal eosinophils in immunity and disease.” The Journal of Immunology. 2014 Aug 1;193(3):999-1005. doi: 10.4049/jimmunol.1400413. Review.

EOSINOPHIL RESOURCES

Please visit www.eosinophil-society.org/eosinophil-resources/website-and-listservs for a link to these resources:

• American Partnership for Eosinophilic Disorders (APFED)

• Children’s Hospital of Philadelphia - Center for Pediatric Eosinophilic Disorders

• Churg Strauss Syndrome Association (CSSA)• Cincinnati Center for Eosinophilic Disorders• Diagnostics Development• HES Listserv• NJ/PA Eosinophilic Support Group• Office of Rare Diseases• TIGER

HOT OFF THE PRESS, CONTINUED

Stay tuned: IES t-shirt competition will be announced in January 2015!

http://www.eosinophil-society.org/eosinophil-resources/website-and-listservs

http://www.eosinophil-society.org/eosinophil-resources/website-and-listservs


WAO BRAZIL 2014Bochner, Bruce Sunday, 7 December, 2014: 08:05 - 08:30 Biologic Basis of the Allergic Response

Wardlaw, Andrew Saturday, 6 December 2014: 16:05 - 16:20 What to do after High Doses of Steroids

Monday, 8 December 2014: 10:35 - 11:00 IL- 4 and IL-13 Blockade in Asthma

Monday, 8 December 2014: 13:45 - 14:05 Endotypes and Treatment of Eosinophilic Airway Diseases

AAAAI HOUSTON 2015Aceves, Seema Sharma

Friday, February 20, 2015: 4:00 PM EoE Beyond Medications: The Emerging Role of Dietary Management; Primary Allergist, Station 3

Saturday, February 21, 2015: 12:30 PM-1:30 PM PPI-Responsive Esophageal Eosinophilia is a Distinct Entity: Con Speaker

Ackerman, Steven Sunday, February 22, 2015: 11:25 AM Eosinophils and Airway Remodeling: New Insights

Alam, Rafeul Saturday, February 21, 2015: 7:00 AM-8:00 AM Non-IgE-Mediated Effects of Allergens: DNA Injury, Tissue Memory and Innate Signaling

Busse, William Saturday, February 21, 2015: 10:45 AM Inner City Asthma Phenotypes: Implications for Treatment Approaches and Disease Severity

Sunday, February 22, 2015: 1:45 PM Advances in Adult Basic Science, Clinical and Translational Asthma Research in the Past Seven Years

Butterfield, Joseph Saturday, February 21, 2015: 7:00 AM-8:00 AM Mastocytosis Mimics: Cutting Through the Clutter

Monday, February 23, 2015: 4:45 PM-6:00 PM Mast Cell Activation Syndromes: Case 2

Collins, Margaret Tuesday, February 24, 2015: 3:30 PM Pathologist: Eosinophils in the Gut: What Is Abnormal?

Furuta, Glenn Saturday, February 21, 2015: 12:30 PM-1:30 PM PPI-Responsive Esophageal Eosinophilia is a Distinct Entity: Pro Speaker

Gleich, Gerald Sunday, February 22, 2015: 7:00 AM-8:00 AM Biomarkers and Asthma: Making Sense of it All

Kita, Hirohito Saturday, February 21, 2015: 11:25 AM Development of Follicular T Cells and Their Roles in Allergic Responses

Saturday, February 21, 2015: 5:00 PM IL-33 and ILC2 and Development of Allergic Sensitization

Klion, Amy Friday, February 20, 2015: 8:45 AM 2015 Chrysalis Project Program: Eosinophilic Disorders

Tuesday, February 24, 2015: 7:00 AM-8:00 AM So the Patient Has Eosinophilia: What Next?

Levi-Schaffer, Francesca

Tuesday, February 24, 2015: 12:30 PM-1:30 PM Inhibitory Receptors on Allergy Effector Cells: New Therapeutic Targets

Minnicozzi, Mike Tuesday, February 24, 2015: 10:45 AM Panel Discussion: NIH Funding Opportunities and Strategies for Success

Members Speaking at other Meetings


AAAAI HOUSTON 2015, CONTINUEDMunitz, Ariel Tuesday, February 24, 2015: 12:30 PM-1:30 PM Inhibitory Receptors on Allergy Effector Cells: New

Therapeutic Targets

Nair, Parameswaran Saturday, February 21, 2015: 4:45 PM Non-Invasive Monitoring of Airway Inflammation in Asthma: Eosinophils in Blood and Induced Sputum

Ogbogu, Princess Friday, February 20, 2015: 5:00 PM EoE Beyond Medications: The Emerging Role of Dietary Management; Primary Allergist, Station 4

Prussin, Calman Saturday, February 21, 2015: 12:30 PM-1:30 PM Quantifying Th2 Immunomodulation in Clinical Trials

Rothenberg, Marc Sunday, February 22, 2015: 1:45 PM New Diagnostic Tools for Diagnosis and Monitoring of Eosinophilic Esophagitis

Monday, February 23, 2015: 10:45 AM How the Esophageal Epithelial Cells Shape the Immune Response in Eosinophilic Esophagitis

Schleimer, Robert Friday, February 20, 2015: 4:00 PM Activation of the Innate and Adaptive Immune Systems in Nasal Polyposis

Sheikh, Javed Tuesday, February 24, 2015: 7:00 AM-8:00 AM Medical Management of Eosinophilic Esophagitis in Adults

Simon, Hans-Uwe Sunday, February 22, 2015: 10:45 AM Molecular Pathways Leading to Eosinophil Cytolysis

Weiler, Catherine Monday, February 23, 2015: 4:45 PM-6:00 PM Mast Cell Activation Syndromes: Case 1

Tuesday, February 24, 2015: 7:00 AM-8:00 AM So the Patient Has Eosinophilia: What Next?

Tuesday, February 24, 2015: 12:30 PM-1:30 PM Aspirin and Antibiotic Desensitization

Weller, Peter Sunday, February 22, 2015: 11:05 AM Eosinophil Cytolysis and Extracellular DNA Trap Formation

EACCI 2015Busse, William Tuesday, June 9, 2015: 10:30 AM - 11:00 AM The pathophysiology of asthma in the elderly

Gauvreau, Gail Monday, June 8, 2015: 3:45 PM - 4:15 PM Thymic stromal lymphopoietin: a central regulator of allergic asthma

Levi-Schaffer, Francesca

Wednesday, June 10, 2015: 11:30 AM - 12:00 PM Eosinophilia and skin diseases

Lloyd, Clare Wednesday, June 10, 2015: 9:30 AM - 10:00 AM Role of epithelial derived IL-33 in allergy

Nair, Parameswaran Monday, June 8, 2015: 10:45 AM - 11:15 AM The clinical use of biomarkers in asthma: Sputum

Simon, Hans-Uwe Monday, June 8, 2015: 10:00 AM - 10:30 AM Eosinophil activation and degranulation

Straumann, Alex Monday, June 8, 2015: 3:45 PM - 4:15 PM Eosinophilic esophagitis in adults and children: different entities?

Valent, Peter Monday, June 8, 2015: 2:15 PM - 2:45 PM Mastocytosis and mast cell activation syndrome

Wardlaw, Andrew Monday, June 8, 2015: 11:45 AM - 12:15 PM Treatment of Aspergillus fumigatus-associated asthma


Request for Proposals: 2019 IES Biennial SymposiumDEADLINE FOR SUBMISSIONS: JUNE 30, 2015

THE APPLICATIONS WILL BE DISCUSSED IN CHICAGO (AT THE 2015 SYMPOSIUM).

Below, we provide information about the process that will be used to decide on the location of the 2019 meeting and proposal information.

When you submit a proposal please discuss the following issues that are of concern to the Board, and to the members of the Society.

1. Distance from Airport - Please include the convenience and cost of transportation to the site from the major cites of Europe, North America and Asia from which our members will be traveling.

2 Hotel Room Rates during the month of July3. Average Temperature during the month of July4. Please provide a list of available conference facilities that

could be used for the Symposium.5. Please include a list of nearby attractions.6. Please include a few novel things about the venue and city.

If it is convenient for you to do so, please send a summary of your responses to the points listed above to Ashley Salmon ([email protected]) with the IES Secretariat, who

then will distribute them to the Board to review.

On behalf of the Board, we want to thank, in advance, those of our colleagues who are willing to consider presenting a proposal for the 2019 meeting and future meetings of our Society. The Board’s objective will be to use its best judgment to choose a site for the 2019 meeting that is likely to be appealing to the majority of our members, and where they can enjoy the traditional collegial scientific and social interactions characteristic of our organization, in a stimulating and interesting site. We look forward to receiving your proposals.

Sincerely,

Hans-Uwe Simon, MD, PhD President, International Eosinophil Society, Inc.

Trainee UpdateNeda FarahiIES Trainee MemberUniversity of Cambridge, UK

Plans are afoot to organize the Chicago 2015 Symposium. One element that we plan to incorporate this year is that trainee members will co-moderate sessions alongside the senior IES members. This will be a fantastic opportunity for trainee members to be more actively engaged in the symposium and develop their own skills of chairing a scientific session.

In other news we had some fantastic entrees for the photo competition, these will be posted online shortly and all IES members will have the opportunity to vote for their favourite

one. For those of you with an artistic streak, there will be another chance to display your creative talents in the form of an eosinophil themed T-shirt competition. Details will be announced early next year.

Finally, if you are a trainee member and want to get more actively involved in the IES affairs (for example participate in a sub-committee or write a newsletter article for trainees) please get in touch with me by email at [email protected]


Cincinnati Children’s Receives NIH Grant To Lead Multicenter Consortium on Eosinophilic DisordersOct. 8, 2014Contact: Jim Feuer513-636-4656

Cincinnati Children’s Hospital Medical Center has received a 5-year, $6.25 million grant from the National Institutes of Health to lead a consortium of organizations from around the country that will conduct clinical research into eosinophilic disorders and train investigators in how to conduct clinical research.

Eosinophilic disorders are chronic inflammatory disorders. These conditions are thought to be triggered by allergic hypersensitivity to certain foods and an over-accumulation in the gastrointestinal tract of white blood cells called eosinophils (part of the body’s immune system). Eosinophilic disorders can cause a variety of gastrointestinal complaints including reflux-like symptoms, vomiting, difficulty swallowing, tissue scarring, fibrosis, the formation of strictures, diarrhea, abdominal pain, failure to grow in childhood and other medical complications.

When inflammation is in the esophagus, the condition is known as eosinophilic esophagitis. When it is in the stomach, the condition is called eosinophilic gastritis. When it is in the colon, it is known as eosinophilic colitis. Although most prior work on these conditions has focused on eosinophilic esophagitis, the new grant will also focus on eosinophilic gastritis and colitis.

“These are painful, lifelong diseases that make it difficult or impossible for individuals to eat many or all foods,” says Marc Rothenberg, MD, PhD, director of the Cincinnati Center for Eosinophilic Disorders at Cincinnati Children’s and principal investigator on the grant. “Individuals with these diseases often have to fuel their bodies by drinking costly formulas. We will collaborate with researchers, patients and patient advocacy groups to better understand, treat and educate about these diseases.”

The grant funds and establishes a Consortium of Eosinophilic Gastrointestinal Disease Researchers referred to by the acronym CEGIR. In addition to Dr. Rothenberg, the grant will be orchestrated by Glenn Furuta, MD, director of the Gastrointestinal Eosinophilic Diseases Program at Children’s Hospital Colorado and professor of pediatrics at the University of Colorado School of Medicine, who will serve as the grant’s administrative director.

CEGIR will also include clinical researchers from Rady Children’s Hospital, Lurie Children’s Hospital, Northwestern University, Riley Children’s Hospital, the National Institutes of Health, Tufts University, University of North Carolina, Children’s Hospital of Philadelphia and Bern University Switzerland.

These sites were chosen on the basis of their previous record of collaboration; expertise in relevant clinical specialties, including gastroenterology, allergy, immunology and pathology; the ability to integrate children and adult patients into the consortium; and their well-established record of excellence in clinical research. These sites are considered the major centers working on these diseases and provide clinical care to more than 8000 patients with the diseases being studied.

The CEGIR will also work with a number of strong patient advocacy groups, including the American Partnership for Eosinophilic Disorders (APFED), the Campaign Urging Research for Eosinophilic Disease (CURED), and the Eosinophilic Family Coalition (EFC).

"Collaborative research is critical for progress in understanding and treating these rare diseases,” says Dr. Furuta. “Little could be accomplished without the support of patients and patient advocacy groups, our professional networks, and clinicians and researchers


from around the globe. These conditions are a global health concern, and it will take everyone working together to address them. We are so fortunate to be able to formalize these collaborations through this new consortium and the stellar infrastructure and processes of the Rare Disease Research Network.”

The NIH grant (U54AI117804) is believed to be the first to establish a network focusing on these three distinct diseases. The funding specifically will further research and clinical expertise, train clinical investigators, pilot clinical research projects, and provide access to information related to eosinophilic disorders for basic and clinical researchers, physicians, patients and the lay public. The grant is funded by the Office of Rare Diseases Research, which is part of the NIH’s National Center for Advance Translational Studies, as part of the Rare Disease Research Network.

This award is co-funded by the National Center for Advancing Translational Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute of Allergy and Infectious Diseases.

ABOUT CINCINNATI CHILDREN’S

Cincinnati Children’s Hospital Medical Center ranks third in the nation among all Honor Roll hospitals in U.S.News and World Report’s 2014 Best Children’s Hospitals. It is also ranked in the top 10 for all 10 pediatric specialties. Cincinnati Children’s, a non-profit organization, is one of the top three recipients of pediatric research grants from the National Institutes of Health, and a research and teaching affiliate of the University of Cincinnati College of Medicine. The medical center is internationally recognized for improving child health and transforming delivery of care through fully integrated, globally recognized research, education and innovation. Additional information can be found at www.cincinnatichildrens.org. Connect on the Cincinnati Children’s blog, via Facebook and on Twitter.

Volunteers are needed to work the IES booth at the AAAAI meeting (February 20-24, 2015).

Please contact the IES Office.

Volunteers Needed!


IES, Inc. Board of DirectorsEXECUTIVE COMMITTEE

President Hans-Uwe Simon, MD PhD (Switzerland)

President-Elect Peter Weller, MD (USA)

Immediate Past-President Amy D. Klion, MD (USA)

Secretary-Treasurer Hirohito Kita, MD (USA)

Scientific Program Director Bruce S. Bochner, MD (USA)

Trainee Board Member Neda Farahi, BSc PhD (United Kingdom)

At-Large DirectorsPatricia T. Bozza, MD PhD (Brazil)Simon P. Hogan, PhD (USA)Leo Koenderman, PhD (The Netherlands)James J. Lee, PhD (USA)Kenji Motsumoto, MD PhD (Japan)Parameswaran Nair, MD (Canada)Marc Rothenberg, MD PhD (USA)Florence Roufosse, MD PhD (Belgium)Lisa Spencer (USA)Andrew Wardlaw, MD (UK)

CONTACT INFORMATION FOR MEMBERSHIP, MEETING, WORKSHOP

Ashley Salmon Membership and Meetings ManagerInternational Eosinophil Society, Inc.555 East Wells StreetSuite 1100Milwaukee, WI 53202Tel: (414) 276-6445Fax: (414) 276-3349 [email protected]

THE EOSINOPHIL NEWS IS SEEKING CONTRIBUTORS — NEXT ISSUE SPRING 2015!

Whether you are interested in writing a recurring column or a one-time piece, have an idea for new content, or information about a newsworthy item, we would like to hear from you. Pictures are always appreciated. Contact Hans-Uwe Simon at [email protected]. To place an ad in the newsletter, contact Ashley Salmon at [email protected].

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