Multi-Focal ERG Systems

leading the wave

Unmatched repeatability;

ERG responses from 15

different systems1

Performance LeaderUnprecedented 1 nano Volt

resolution and illuminated

receptacles guide lead

insertion and electrode

contact quality

32-Bit Amplifi erHandheld Ganzfeld

stimulator option; enables

optimal Pediatric and

Operating Room ERG testing

ColorBurst™

1Rustum Karanjia, Martin W. ten Hove and Stuart G. Coupland (2011). Electroretinograms and Normative Data, Electroretinograms, Dr. Gregor Belusic (Ed.), InTech, DOI: 10.5772/23387.

E3 consoles are paired with high performance LCD monitors and integrated patient chin rest

E3 with LCD Monitor SystemOur advanced high brightness and fast response monitors are custom engineered to

enable very effective clinical diagnostic testing

Diagnosys offers a selection

of high performance fi xation

monitoring cameras that

integrate with Espion™

software

Fixation Cameras

LCD monitor features:• Brightness up to 1,000 cd/m2

• Contrast up to 3,000:1• Compact screen sizes

Fully compliant ISCEV

standard PERG and

pVEP are delivered

using the miniature

OLED monitor which

enables unprecendented

repeatability

22" desktop all-in-one

computer with Espion

software and SQL relational

database enables fast

testing and reporting;

computer can be off-cart

(Europe only)

Integrated Computer Pattern Stimulator

Blue Profi le™ SystemOur fully integrated cart-based systems enable compact funtionality in a mobile system

for use throughout your facility

!!!

Multi-Focal ERG Systems leading the wave

Multi-Focal ERG Features

3rd Generation advanced performance • All multi-focal and pattern visual electrophysiology tests possible • Industry leading 32-bit amplifiers: <1 Nano-Volt resolution • Advanced brightness and fast response monitors engineered for mfERG • Unprecedented ERG repeatability

Modular, full features, easy to use • 5 powerful stimulators you can mix & match • Most cost effective, compact and mobile systems on the market • Set up system and initiate testing in hours • Unique, electrode testing amplifier speeds patient set-up • Most widely used system world-wide

Choose from the broadest range of stimulators in the industry:

Stimulator Performance LCD Performance LCD ColorBurst 19” CRT Envoy Mini Pattern Stimulator

Primary use Multi-focal ERG Multi-focal ERG Pediatric, OR, handheld Ganzfeld

Pattern ERG, VEP

Pattern ERG, VEP

Applications Full range of retina functional test: clinical diagnostics, clinical trials, clinical safety studies, Stem cell & genetic research, Neuro-ophthalmology, R&D, advanced diagnostics

Configuration options

Cart-based system Desktop system with E3 console

With or without stand

Protocols ISCEV multi-focal ERG (mfERG)

ISCEV multi-focal ERG (mfERG)

ISCEV full-field ERG (6 tests)

ISCEV PERG ISCEV PERG

Pattern VEP* Pattern VEP* Dark-adapted 30 ERG ISCEV mfERG Multi-focal ERG Uniform field PERG Uniform field

PERG Long duration flash ISCEV VEP ISCEV Pattern

VEP Multi-focal PhNR

(mfPhNR) Multi-focal PhNR (mfPhNR)

Flash VEP ISCEV Pattern VEP

Uniform field PERG

Sweep VEP Sweep VEP Uniform field PERG mfVEP Multi-focal VEP** Multi-focal VEP** PhNR Uniform field

PERG

Scotopic threshold response

mfPhNR

Double flash ERG Other: see ColorBurst

brochure

Notes: 1) *Non-ISCEV standard protocol, 2) **In development at Diagnosys

UK: Diagnosys UK LTD ! 5 Trust Court, Vision Park ! Histon, Cambridge, CB24 9PW ! Phone/Fax: +44 (0) 1223 520699 ! Email: mail@diagnosysuk.co.uk

!

!!

The information listed herein is accurate as of the date of printing, however may change at any time without notice. The contents may differ from the current status of approval of the product in your country. Please contact your local Diagnosys representative for more information © 2016 by Diagnosys, LLC. All copyrights reserved.

Doc: #14682 Rev: #C ECN 1168 Date: 9/27/2018

US: Diagnosys LLC USA ! 55 Technology Dr, Suite 100 ! Lowell, MA 01851 USA ! Phone: 978.458.1600 ! Fax: 978.458.1755 ! Email: sales@diagnosysllc.com www.diagnosysllc.com

System specifications ERG Controller • Advanced real-time acquisition system with integrated power isolation

• Direct pattern generator • Isolated auxiliary line outlets to meet medical leakage current standards• All-digital filtering • Hardened, machined aluminum case • Advanced, medically qualified power-lift cart (Profile systems)

Amplifier • Full DC 2-channel, fully differential, 32-bit amplifiers have 1 nano Volt resolution, which provide the highest resolution in the industry; ultra low noise

• 5 Volt input range, ensures amplifier will not over-range • Common mode rejection: >100 dB

Stimulators Refer to individual stimulator brochures Computer Desktop all-in-one computer or Laptop computer; Runs on Windows® 7 through 10 Espion Software • Automatic rejection

• Peak/trough detect & measure • SQL relational database • Multiple operator modes

Cameras Included with LCD monitor

System configurations 1. Model number: D310 (Profile cart-based systems) Configuration: select 1 option per field below Note: all systems come with an ERG controller, 32-bit amplifier, computer, Espion software, cart and starter accessory kit.

2. Model number: D315 (E3 desktop systems) Configuration: select 1 option per field below Note: all systems come with an E3 console, 32-bit amplifier with stand, computer, Espion software and starter accessory kit.

Optional accessories Model Description

D354 19” CRT

D370 Sweep VEP

US: Diagnosys LLC USA ● 55 Technology Dr, Suite 100 ● Lowell, MA 01851 USA ● Phone: 978.458.1600 ● Fax: 978.458.1755 ● Email: sales@diagnosysllc.comUK: Diagnosys UK LTD ● 5 Trust Court, Vision Park ● Histon, Cambridge, CB24 9PW ● Phone/Fax: +44 (0) 1223 520699 ● Email: mail@diagnosysuk.co.uk

Simplify your visual electrophysiology

If you would like more information on Diagnosys products,

please contact us at either our US or UK locations.

Doc #: 14682 Rev: C ECN #: 1168 Date: 9/27/2018

Ordering information:Model #: D310 (Blue Profi le System) D315 (E3 system with an LCD monitor)

System options: Normative data DICOM print module Envoy Mini OLED monitor for PERG and pVEP Sweep VEP module

www.diagnosysllc.com

The industry leader. Decades of experience, thousands of installations.

• Most experienced customer support team in the industry• Hundreds of peer-reviewed papers published using our systems• Extensive world-wide network of leading experts operating Diagnosys systems

Diagnosys Lab 1 of 1 [Espion: 0-999 V6.2012.109.50]

Patient: NORMAL, DOB:1/1/1950, Female Examiner: Natalie Doran Date Tested: 1/1/2012 (Updated: 11/16/2015) Time Tested: 9:50:40 AM Test Comment: Done w ith trial lenses Unique ID: B6E89837-5E8E-419E-BC71-01D6-05AA-BFA6 61 Hex 60 degree [11-Mar-2010] Normal patients will show a strong central peak and moderate peripheral responses in the surface plot. Traces should line up fairlywell against normative data, and group averages should show markers within the normative data boxes. Patients with excellent fixation may even show a dip in function at the location of the blind spot.

1

2

3

4

5

Response Density index Hex n Area deg² P1 ms P1 nV

1 1 19.8 32.4 462.8* 2 6 27.6 31.0 450.7* 3 12 38.5 30.3 321.1* 4 18 49.3 31.1 274.6* 5 24 57.7 31.5 276.9*

50nV

/deg

²

50ms

Group AveragesConcentric Rings [RE]

1

2

3

4

5

Response Density index Hex n Area deg² P1 ms P1 nV

1 1 19.8 32.4 538.0* 2 6 27.6 31.5 420.6* 3 12 38.5 31.1 303.5* 4 18 49.3 30.8 258.9* 5 24 57.7 30.9 257.8*

50nV

/deg

²

50ms

Group AveragesConcentric Rings [LE]

50ms

500n

V

T NTrace ArrayTraces Average[3],Adaptive[3],Secondary Smoothed Normals [RE]

Retinal (TN)

50ms

500n

V

N TTrace ArrayTraces Average[3],Adaptive[3],Secondary Smoothed Normals [LE]

Retinal (TN)

NT

nV/deg²8.0

6.0

4.0

2.0

0.0

NT

Patient 3-D TopographyRMS Density x Normals nV/deg² [RE]

TN

nV/deg²8.0

6.0

4.0

2.0

0.0

TN

Patient 3-D TopographyRMS Density x Normals nV/deg² [LE]

Espion™ software provides detailed test reports that are concise and easy to interpret (ISCEV standard mfERG tests using a multi-focal ERG system shown).