(IX) Shu-Chi Chang, Ph.D., P.E., P.A.Assistant Professor1 and Division Chief21Department of Environmental Engineering2Division of Occupational Safety and Health, Center for Environmental Protection and Occupational Safety and HealthNational Chung Hsing University

Tuesday, November 25, 2008

Outline

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SARSwww.redcross.org

SARS(severe acute respiratory syndrome, SARS)(WHO)2003315SARS2710(38)XSARS842291611%2003SARS2003

6750%-80%71

39-405-624341% 15-50%

(1)Avian Influenza virus, or Bird fluAInfluenza ARNA

(2): 53.9%

(Biosafety Level, BSL)

BSL1Risk group 1 , RG1

Bacillus licheniformis, Escherichia coli-K12, adeno-associated virusadeno-associated virus

BSL2Risk group 2 , RG2

Escherichia coliK1E. coli O157H7MycobacteriumM. avium complex, M. asiaticum, M. bovis BCG vaccine strain, M. chelonei, M. fortuitum, M. kansasii, M. leprae, M. malmoense, M. marinum, M. paratuberculosis, M. scrofulaceum, M. simiae, M. szulgai, M. ulcerans, M. xenopi SalmonellaS. arizonae, S. cholerasuis, S. enteritidis, S. gallinarum-pullorum, S. meleagridis, S. paratyphi, A, B, C, S. typhi, S. typhimuriumShigellaS. boydii, S. dysenteriae, type 1, S. flexneri, S. sonnei

BSL3

.Mycobacterium bovisBCG, M. tuberculosis Coronaviruses: SARS-associated Coronaviruses (SARS-CoV)FlavivirusesTogaviruses- Group B ArbovirusesWest Nile Virus Yellow fever virusPrionsTransmissible spongioform encephalopathiesTSEagentsCreutzfeldt-Jacob disease and kuru agentsRetrovirusesa. Human immunodeficiency virusHIVtypes 1 and 2b. Human T cell lymphotropic virusHTLVtypes 1 and 2c. Simian immunodeficiency virusSIV

BSL4 Filovirusesa. Ebola virus (50-90%)b. Marburg virus (21-88%)

(Physical Containment Level)P1P2P3P420LS-CLS-1LS-2(BSLBiosafety Level)DNABSL-1BSL-2BSL-3BSL-4ABSL-1ABSL-2ABSL-3ABSL-4

(Risk group 1 , RG1)(Risk group 2 , RG2)(Risk group 3 , RG3)(Risk group 4 , RG4)

200444/224/265/135/28C-prM

20069P2: 9(2006/9/17)(Shigella flexneri )

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2-650%32191819465-1 5.2.2 1961DDTDDTDDT20035.2.3 10%1/4 10-15 70%5-2 1960

5.2.4 5-3 5.2.5 6750%-80%7119981999711-25-4 5.2.6 (severe acute respiratory syndrome, SARS)(WHO)2003315SARSSARS2710(38)XSARS20021120032SARS20033SARS715SARS2003416WHOSARSSARSSARS2002-3SARS842291611%2003SARS2003

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4/224/265/135/28C-prM

93614(1200 N)