ثوحبلل ىموقلا زكرملا center of scientific excellence for influenza ... · center...

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Center of Scientific Excellence

for Influenza Viruses

Prof.Dr. Mohamed Ahmed Ahmed Ali, Director

Project ID # 5175

Problem Definition: Viral threats have made a lasting impact on human population for thousands of years. One of the earliest records of an emerging infectious disease dates back to ancient Egyptians (1500 BC) where poliomyelitis and smallpox were emerged and killed many people, Greece (430 BC) with the devastating Plague of Athens, which killed an estimated 40,000 people. Many of the most serious viruses are emerged in the 20th century (like Hepatitis, AIDs, Mosquito-borne viruses and most of the human, animal and zoonotic viruses. At the beginning of the 21th century, some new viruses were emerged as SARS and MERS-CoV. Some other viruses are crossed the species barrier to infect humans as avian influenza H5N1. On October 2012,a novel coronavirus had been emerged and infect human in the KSA and spread to the Arabian peninsula and other countries in the world. Zika and ebola viruses reemerged in different countries other than African countries and recorded outbreaks. This means that new and re-emerging infectious disease threats will continue to challenge the world. The risk impact of emerging viral diseases is referred to:

• Easy spreading. • High capability to mutate. • Lack of effective drug or vaccine for most of them. • Extension of host specificity and cross species barrier.

To face these challenges we have to: 1. Establish a laboratory capable of studying these viruses whether of animal

or human origin. 2. Study the ecology of these viruses in Egyptian environment. 3. Study the epidemiology of virus infection in the Egyptian population. 4. Characterize these viruses genetically and antigenically. 5. Introduction of approaches toward vaccine development. 6. Study the efficacy of commercial vaccines under laboratory and field

settings. 7. Study alternative vaccine strategies to solve problems related to vaccines

produced under traditional methods.

صندوق العلوم والتنمية التكنولوجيةScience & Technology Development Fund

مركز التميز العلمى لفيروسات األنفلونزاCenter of Scientific Excellence for Influenza Viruses

المركز القومى للبحوثNational Research Centre

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8. Monitor the newly emerging and reemerging viruses.

1. Establish a laboratory capable of studying these viruses whether of animal or human origin: • Our laboratory is currently equipped with state of the art equipment and

have well trained scientists capable of conducting virus culture, molecular analysis, antigenic characterization, serological testing, and reverse genetics technology.

• Our equipment include state of the art equipment such as: Thermal cyclers, real time PCR machine, level III biological safety cabinet, 96-cage self-contained mouse rack, CO2 incubators and others.

• We are the only laboratory in Egypt that is allowed to use the reverse genetic technology and the only laboratory that have the necessary plasmids to conduct such work based on agreement with St. Jude Children’s Research Hospital, USA.

• We have a library of all human and avian influenza viruses (H1 – H16), and other reference viruses, polyclonal and monoclonal antibodies, and typing and sequencing primers for all subtypes.

2. Study the ecology of these viruses in Egyptian environment. • We have one of the few systematic prospective poultry surveillance system

for influenza viruses conducted in various governorates in the Nile Delta and Upper Egypt.

• Through this surveillance system, we are able to monitor the evolution of H5N1 virus in Egyptian poultry as well as detecting the emergence of H9N2 and its cocirculation with H5N1 in Egyptian poultry.

• We are also able to shed light on the reservoirs and foci of influenza viruses in Egypt.

• We could for the first time MERS-CoV in imported Camels.

3. Study the epidemiology of virus infection in the Egyptian population. • We currently have an ongoing prospective cohort of 750 Egyptians exposed

to poultry and 250 individuals with no poultry exposure. • For this study, we collect serum samples on an annual basis as well as swabs

whenever our subjects report influenza-like illness symptoms. • We developed a microneutralization assay using a reverse genetics antigen to

test the collected sera for antibodies against avian influenza viruses. We also use horse blood, chicken blood, and turkey blood hemagglutination inhibition assays.

• Through this study, we were able to measure the seroprevalence of H5 antibodies in our study population and calculated the prevalence to be 2%.

4. Characterize these viruses genetically and antigenically. • Through our molecular analysis capabilities we were able to sequence and

analyze a large collection of H5N1 and H9N2 influenza viruses and reported our findings on the genetic characteristics and mutations of these viruses in peer reviewed journals.

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• We used our panel of monoclonal and polyclonal antibodies to characterize the Egyptian avian influenza viruses antigenically.

• We routinely conduct antiviral sensitivity studies on influenza viruses and study the potential antiviral effects of synthetic and natural compounds.

5. Introduction of approaches toward vaccine development. • Through our surveillance and reverse-genetics capabilities we were able to

select the H5N1 virus strains and prepare low-pathogenic reassortants suitable for poultry vaccine production.

• Our vaccine strains were used to produce vaccines locally through the Ministry of Agriculture as well as a private sector manufacturing facility.

6. Study the efficacy of commercial vaccines under laboratory and field settings. • We have conducted vaccine efficacy trials in laboratory settings using specific

pathogen free chickens as well as in a field setting using commercial breeds of chickens in Egypt.

• Our findings indicate that although commercial vaccines are efficacious in the lab, this efficacy is decreased in the field.

• We were the first to report the potential role of maternal antibodies in decreasing the efficacy of vaccines in chickens and recommend vaccination to be at day 10-14 of the chick age.

• We recommended that vaccines used for poultry in Egypt should be based on Egyptian isolates.

7. Study alternative vaccine strategies to solve problems related to vaccines

produced under traditional methods. • We are currently experimenting with various alternative vaccine strategies

including DNA vaccines, virus-like particles vaccines, synthetic genes carrying epitopes of several influenza subtypes, and various reassortant vaccine seeds.

The main output of the Project

• 14 International publications (Scopus). • 196 full gene sequence deposited in GeneBank. • 2 Patents. • Prizes • Training • Post graduates

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Publications

1. Ahmed Kandeil, Joseph T. Hicks, Ahmed S. Kayed, Ahmed N. El Taweel, Omnia Kutkat, Yassmin Moatasim, Ola Bagato, Basma Sheta, Pamela P. McKenzie, Zhipeng Cai, Rebecca Badra, Justin Bahl, Richard J. Webby, Ghazi Kayali and Mohamed A. Ali (2019).Surveillance for Avian Influenza Viruses in Wild Birds at Live Bird Markets, Egypt, 2014-2016.Influenza and Other respiratory viruses,:1-8.

2. Amira Adel Al-Hosary, Ahmed Nageh El-Taweel, Ann Nordengrahn, Malik Merza, Rebecca Badra, Ghazi Kayali , Mohamed Ali (2019). Co-infection with different serotypes of FMDV in vaccinated cattle in Southern Egypt. Virus Genes (Accepted).

3. Ahmed Kandeil, Mokhtar Gomaa, Mahmoud Shehata, Ahmed Nageh, Ahmed Kayed, Awatef Abiadh, Jamel Jrijer, Yassmin Moatassim, Omnia Kutkat, Ola Bagato, Sara Mahmoud, Ahmed Mostafa, Rabeh El-Shesheny, Ranawaka APM Perera, Ronald LW Ko, Nagla Hassan, Basma Elsokary, Lotfi Allal, Ahmed Saad, Heba Sobhy, Pamela McKenzie, Richard Webby, Malik Peiris, Ghazi Kayali, and Mohamed A. Ali (2019). Middle East Respiratory Syndrome coronavirus infection in non-camelid domestic mammals. Emerging Microbs and Infection, 8(1):103-108. doi.org/10.1080/22221751.2018.1560235

4. Kandeil A, Gomaa MR, Shehata MM, El Taweel AN, Mahmoud SH, Bagato O, Moatasim Y, Kutkat O, Kayed AS, Dawson P, Qiu X, Bahl J, Webby RJ, Karesh WB, Kayali G, Ali MA. (2019). Isolation and characterization of a distinct influenza A virus from Egyptian bats. J Virol. 93(2). pii: e01059-18. doi: 10.1128/JVI.01059-18.

5. Ahmed Kandeil, Jamal S. M. Sabir, Ahmed Abdelaal, Ehab H. Mattar, Ahmed N. El-Taweel, Mumdooh J. Sabir, Ahmed Aly Khalil, Richard Webby, Ghazi Kayali, and Mohamed A. Ali (2018). Efficacy of commercial vaccines against newly emerging avian influenza H5N8 virus in Egypt. Scientific Report, 8(1), 9697.

6. Nouran Y. Hamed, Ahmed Kandeil, Jamal S. M. Sabir, Salah E. M. Abo-Aba, Nahid H. hajrah, Mohammad K. Al-ghamdi, Alawiah M. Alhibshi, Abdelfatteh El Omri, Areej K. Al-gamdi, Mohamed A. Ali (2018). Effect of antigen content on avian influenza vaccine efficiency. Journal of Experimental Biology and Agricultural Sciences; 6(6):997 – 1003.

7. Nagwa E. Awad, Hanaa A. Kassem, Manal A. Hamed, Amal M. Elfiki,Mohamed A. A. Elnaggar, Khaled Mahmoud , Mohamed A. Ali (2018). Isolation and characterization of the bioactive metabolites from the soil derived fungus Trichoderma viride, Mycology 9(1):70-80, DOI: 10.1080/21501203.2017.1423126.

8. Gomaa MR, Kandeil A, El-Shesheny R, Shehata MM, McKenzie PP, Webby RJ, Ali MA, Kayali G.(2018). Evidence of infection with avian, human, and swine influenza viruses in pigs in Cairo, Egypt. Arch Virol. 163(2), 359-364. doi: 10.1007/s00705-017-3619-3.

9. Samar S. Tawfik, Abdelbasset A. Farahat*, Magda A.-A El-Sayed, Atif S. Tantawy, Ola Bagato,Mohamed A. Ali (2018). Synthesis and Anti-influenza Activity of Novel Thiadiazole, Oxadiazole and Triazole Based Scaffolds. Letters in Drug Design & Discovery; 15 (4): 363 – 374. DOI : 10.2174/1570180814666170512122832.

10. Ahmed Kandeil, Ahmed Mostafa, Rabeh El-Shesheny, Ahmed Nageh El-Taweel, Mokhtar Gomaa, Hussein Galal, Ghazi Kayali, Mohamed A. Ali (2018): Avian influenza H5N1 vaccination efficacy in Egyptian backyard poultry. Vaccine 35 (45):6195-6201., doi: 10.1016/j.vaccine.

11. Yassmin Moatasim, Ahmed Kandeil, Ahmed Mostafa, Sary Khaleel Abd Elghaffar, Rabeh El Shesheny, Ahmed Helmy M Elwahy, Mohamed Ahmed Ali (2017): Single gene reassortment of highly pathogenic avian influenza A H5N1 in the low pathogenic H9N2 backbone and its impact on pathogenicity and infectivity of novel reassortant viruses. Archives of Virology; 162(10)::2959–2969., DOI:10.1007/s00705-017-3434-x.

12. Ahmed Kandeil, Ahmed Kayed, Yassmin Moatasim, Richard J. Webby, Pamela P. McKenzie, Ghazi Kayali, Mohamed A. Ali (2017): Genetic characterization of highly pathogenic avian influenza A H5N8 viruses isolated from wild birds in Egypt. Journal of General Virology; 98(7). DOI:10.1099/jgv.0.000847.

https://doi.org/10.1080/22221751.2018.1560235

https://www.ncbi.nlm.nih.gov/pubmed/?term=Kandeil%20A%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Gomaa%20MR%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Shehata%20MM%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=El%20Taweel%20AN%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Mahmoud%20SH%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Bagato%20O%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Moatasim%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Moatasim%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Kutkat%20O%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Kayed%20AS%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Dawson%20P%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Qiu%20X%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Bahl%20J%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Webby%20RJ%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Karesh%20WB%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Kayali%20G%5BAuthor%5D&cauthor=true&cauthor_uid=30381492

https://www.ncbi.nlm.nih.gov/pubmed/?term=Ali%20MA%5BAuthor%5D&cauthor=true&cauthor_uid=30381492


https://www.ncbi.nlm.nih.gov/pubmed/?term=bat+flu+virus+in+Egypt

https://www.ncbi.nlm.nih.gov/pubmed/?term=Gomaa%20MR%5BAuthor%5D&cauthor=true&cauthor_uid=29075888

https://www.ncbi.nlm.nih.gov/pubmed/?term=Kandeil%20A%5BAuthor%5D&cauthor=true&cauthor_uid=29075888

https://www.ncbi.nlm.nih.gov/pubmed/?term=El-Shesheny%20R%5BAuthor%5D&cauthor=true&cauthor_uid=29075888

https://www.ncbi.nlm.nih.gov/pubmed/?term=Shehata%20MM%5BAuthor%5D&cauthor=true&cauthor_uid=29075888

https://www.ncbi.nlm.nih.gov/pubmed/?term=McKenzie%20PP%5BAuthor%5D&cauthor=true&cauthor_uid=29075888

https://www.ncbi.nlm.nih.gov/pubmed/?term=Webby%20RJ%5BAuthor%5D&cauthor=true&cauthor_uid=29075888


https://www.ncbi.nlm.nih.gov/pubmed/?term=Kayali%20G%5BAuthor%5D&cauthor=true&cauthor_uid=29075888

https://www.ncbi.nlm.nih.gov/pubmed/?term=Evidence+of+infection+with+avian%2C+human%2C+and+swine+influenza+viruses+in+pigs+in+Cairo%2C+Egypt

https://doi.org/10.2174/1570180814666170512122832

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13. Ahmed Kandeil, Rabeh El-Shesheny, Asmaa Maatouq, Yassmin Moatasim, Zhipeng Cai, Pamela McKenzie, Richard Webby, Ghazi Kayali, Mohamed Ahmed Ali (2016): Novel reassortant H9N2 viruses in pigeons and evidence for antigenic diversity of H9N2 viruses isolated from quails in Egypt. Journal of General Virology; 98(4), DOI:10.1099/jgv.0.000657.

14. Rabeh El-Shesheny, Ahmed Mostafa, Ahmed Kandeil, Sara H. Mahmoud, Ola Bagato, Amel Naguib, Samir El Refaey, Richard J. Webby, Mohamed A. Ali, Ghazi Kayali (2016): Biological characterization of highly pathogenic avian influenza H5N1 viruses that infected humans in Egypt in 2014-2015. Archives of Virology;, DOI:10.1007/s00705-016-3137-8

15. Rabeh El-Shesheny, Ola Bagato, Ahmed Kandeil, Ahmed Mostafa, Sara H. Mahmoud, Hamdi M. Hassanneen, Richard J. Webby, Mohamed A. Ali, Kayali Ghazi (2016): Re-emergence of amantadine-resistant variants among highly pathogenic avian influenza H5N1 viruses in Egypt. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases; 46: 102-109. DOI:10.1016/j.meegid.2016.10.022.

16. A.S. Kayed, A. Kandeil, R. El Shesheny, M.A. Ali, G. Kayali (2016). Active surveillance of avian influenza viruses in Egyptian poultry, 2015. East Mediterr Health J.; 22(7):557-561.

17. Mokhtar R. Gomaa, Ahmed Kandeil, Ahmed S. Kayed, Mona A. Elabd, Shaimaa A. Zaki, Dina Abu Zeid, Amira S. El Rifay, Adel A. Mousa, Mohamed M. Farag, Pamela P. McKenzie, Richard J. Webby, Mohamed A. Ali, Ghazi Kayali (2016): Serological Evidence of Human Infection with Avian Influenza A H7virus in Egyptian Poultry Growers. PLoS ONE 06/2016; 11(6):e0155294., DOI:10.1371/journal.pone.0155294.

18. Ghazi Kayali, Ahmed Kandeil, Rabeh El-Shesheny, Ahmed S. Kayed, Asmaa M. Maatouq, Zhipeng Cai, Pamela P. McKenzie, Richard J. Webby, Samir El Refaey, Amr Kandeel, Mohamed A. Ali (2016): Avian influenza A(H5N1) virus in Egypt. Emerging infectious diseases 03/2016; 22(3)., DOI:10.3201/eid2203.150593.

19. Ahmed Kandeil, Yassmin Moatasim, Mokhtar R. Gomaa, Mahmoud M. Shehata, Rabeh El-Shesheny, Ahmed Barakat, Richard J. Webby, Mohamed A. Ali, Ghazi Kayali (2016): Generation of a reassortant avian influenza virus H5N2 vaccine strain capable of protecting chickens against infection with Egyptian H5N1 and H9N2 viruses. Vaccine; 34(2)., DOI:10.1016/j.vaccine.2015.11.037.

20. Amna M. Abdella, Yassmin Moatasim, Mohamed A. Ali, Ahmed H. M. Elwahy, Ismail A. Abdelhamid (2017): Synthesis and Anti-influenza Virus Activity of Novel bis(4 H -chromene-3-carbonitrile) Derivatives: Anti-influenza Virus Activity of bis(4H-chromene-3-carbonitrile) Derivatives. Journal of Heterocyclic Chemistry; 54(3): 1854-1862, DOI:10.1002/jhet.2776.

21. F.K. El-Baz, O. Bagato, H.F. Aly, S A. Saad, M.A. Ali and A.A. Mohamed (2015). Comparative evaluation of jatropha curcas leaves extract for antibacterial, anti avian influenza A virus (H5N1) properties and GC-MS profile. Int J Pharm Bio Sci; 6(2): (B) 108 – 120.

22. N.A. Ibrahim, S.S. El-Hawary, M.M.D. Mohammed, M.A. Farid, N.A.M. Abdel-Wahed, M.A. Ali, E.A.W. El-Abd (2015): Chemical composition, antiviral against avian influenza (H5N1) virus and antimicrobial activities of the essential oils of the leaves and fruits of Fortunella margarita, lour. swingle, growing in Egypt. Journal of Applied Pharmaceutical Science; 5(1):006-012., DOI:10.7324/JAPS.2015.50102.

23. Alaa A. Gaafar, Mohsen S. Asker, Zeinab A. Salama, Bagato O., Ali MA (2015). In-vitro, Antiviral, Antimicrobial and Antioxidant Potential Activity of Tomato pomace. Int. J. Pharm. Sci. Rev. Res., 32(2), Article No. 44, Pages: 262-272.

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Genes Deposited in GeneBank

Year Authors Accession

No. Name of the Gene No.

2017

Kandeil,A., Kayed,A., Moatasim,Y., Webby,R., McKenzie,P.P., Kayali,G. and Ali,M.A.

MF037863.1

Influenza A virus (A/green-winged teal/Egypt/877/2016(H5N8)) segment 1 polymerase PB2 (PB2) gene

1

2017

Kandeil,A., Kayed,A., Moatasim,Y., Webby,R., McKenzie,P.P.,Kayali,G. and Ali,M.A.

MF037862.1

Influenza A virus (A/green-winged teal/Egypt/877/2016(H5N8)) segment 4 hemagglutinin (HA) gene

2

2017

Kandeil,A., Kayed,A., Moatasim,Y., Webby,R., McKenzie,P.P.,Kayali,G. and Ali,M.A

MF037861.1

Influenza A virus (A/green-winged teal/Egypt/877/2016(H5N8)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes

3

2017

Kandeil,A., Kayed,A., Moatasim,Y., Webby,R., McKenzie,P.P.,Kayali,G. and Ali,M.A

MF037857.1

Influenza A virus (A/green-winged teal/Egypt/877/2016(H5N8)) segment 6 neuraminidase (NA) gene

4

2017


MF037855.1

Influenza A virus (A/green-winged teal/Egypt/877/2016(H5N8)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes

5

2017


MF037853.1

Influenza A virus (A/green-winged teal/Egypt/877/2016(H5N8)) segment 5 nucleocapsid protein (NP) gene

6

2017


MF037850.1

Influenza A virus (A/green-winged teal/Egypt/877/2016(H5N8)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes

7

2017


MF037849.1

Influenza A virus (A/green-winged teal/Egypt/877/2016(H5N8)) segment 2 polymerase PB1 (PB1) and putative PB1-F2 protein (PB1-F2) genes

8

2017

Kandeil,A., Kayed,A., Moatasim,Y., Webby,R., McKenzie,P.P., Kayali,G. and Ali,M.A.

MF037860.1

Influenza A virus (A/green-winged teal/Egypt/871/2016(H5N8)) segment 2 polymerase PB1 (PB1) and putative PB1-F2 protein (PB1-F2) genes

9

2017


MF037859.1

Influenza A virus (A/green-winged teal/Egypt/871/2016(H5N8)) segment 1 polymerase PB2 (PB2) gene

10

2017


MF037858.1

Influenza A virus (A/green-winged teal/Egypt/871/2016(H5N8)) segment 5 nucleocapsid protein (NP) gene

11

2017


MF037856.1

Influenza A virus (A/green-winged teal/Egypt/871/2016(H5N8)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes

12

7

2017


MF037854.1

Influenza A virus (A/green-winged teal/Egypt/871/2016(H5N8)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes

13

2017


MF037852.1

Influenza A virus (A/green-winged teal/Egypt/871/2016(H5N8)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes

14

2017


MF037851.1

Influenza A virus (A/green-winged teal/Egypt/871/2016(H5N8)) segment 4 hemagglutinin (HA) gene

15

2017


MF037848.1

Influenza A virus (A/green-winged teal/Egypt/871/2016(H5N8)) segment 6 neuraminidase (NA) gene

16

2017 Rubrum,A., Jeevan,T., Kayali,G., Ali,M.A., Kandeil,A.,El-Shesheny,R. and Webby,R.

KY558870.1 Influenza A virus (A/chicken/Egypt/N12638D/2016(H5N1)) segment 4 hemagglutinin (HA) gene

17


KY558869.1 Influenza A virus (A/chicken/Egypt/N12643B/2016(H5N1)) segment 6 neuraminidase (NA) gene

18


KY558868.1 Influenza A virus (A/chicken/Egypt/F12168D/2016(H9N2)) segment 4 hemagglutinin (HA) gene

19


KY558867.1 Influenza A virus (A/chicken/Egypt/F12170A/2016(H9N2)) segment 4 hemagglutinin (HA) gene

20


KY558866.1 Influenza A virus (A/chicken/Egypt/F12505C/2016(H5N1)) segment 4 hemagglutinin (HA) gene

21


KY558865.1 Influenza A virus (A/chicken/Egypt/F12170A/2016(H9N2)) segment 6 neuraminidase (NA) gene

22

2017

Rubrum,A., Jeevan,T., Kayali,G., Ali,M.A., Kandeil,A.,El-Shesheny,R. and Webby,R.

KY558864.1 Influenza A virus (A/chicken/Egypt/F12505B/2016(H5N1)) segment 6 neuraminidase (NA) gene

23


KY558863.1 Influenza A virus (A/chicken/Egypt/F12505E/2016(H5N1)) segment 6 neuraminidase (NA) gene

24


KY558862.1 Influenza A virus (A/chicken/Egypt/N12642E/2016(H5N1)) segment 6 neuraminidase (NA) gene

25


KY558861.1 Influenza A virus (A/chicken/Egypt/F12505C/2016(H5N1)) segment 6 neuraminidase (NA) gene

26


KY558860.1 Influenza A virus (A/chicken/Egypt/F12168B/2016(H9N2)) segment 4 hemagglutinin (HA) gene

27


KY558859.1 Influenza A virus (A/chicken/Egypt/F12168D/2016(H9N2)) segment 6 neuraminidase (NA) gene

28

2017 Rubrum,A., Jeevan,T., Kayali,G., Ali,M.A., Kandeil,A., El-Shesheny,R. and Webby,R.

KY558858.1 Influenza A virus (A/chicken/Egypt/N12640A/2016(H5N1)) segment 4 hemagglutinin (HA) gene

29

2017 Rubrum,A., Jeevan,T., Kayali,G., KY558857.1 Influenza A virus 30

https://www.ncbi.nlm.nih.gov/nuccore/KY558869.1



8

Ali,M.A., Kandeil,A.,El-Shesheny,R. and Webby,R.

(A/chicken/Egypt/S12568C/2016(H9N2)) segment 4 hemagglutinin (HA) gene


KY558856.1 Influenza A virus (A/chicken/Egypt/F12170E/2016(H9N2)) segment 4 hemagglutinin (HA) gene

31


KY558855.1 Influenza A virus (A/chicken/Egypt/F12168B/2016(H9N2)) segment 6 neuraminidase (NA) gene

32


KY558854.1 Influenza A virus (A/chicken/Egypt/S12568C/2016(H9N2)) segment 6 neuraminidase (NA) gene,

33


KY558853.1 Influenza A virus (A/chicken/Egypt/F12173D/2016(H9N2)) segment 4 hemagglutinin (HA) gene

34


KY558852.1 Influenza A virus (A/chicken/Egypt/N12642E/2016(H5N1)) segment 4 hemagglutinin (HA) gene

35



36

2017 Rubrum,A., Jeevan,T., Kayali,G., Ali,M.A., Kandeil,A.,El-Shesheny,R. and Webby,R

KY558850.1 Influenza A virus (A/chicken/Egypt/N12643B/2016(H5N1)) segment 4 hemagglutinin (HA) gene,

37


KY558849.1 Influenza A virus (A/chicken/Egypt/N12638D/2016(H5N1)) segment 6 neuraminidase (NA) gene,

38



39


KY558847.1 Influenza A virus (A/chicken/Egypt/F12505B/2016(H5N1)) segment 4 hemagglutinin (HA) gene,

40


KY558846.1 Influenza A virus (A/chicken/Egypt/F12054D/2016(H9N2)) segment 4 hemagglutinin (HA) gene,

41


KY558845.1 Influenza A virus (A/chicken/Egypt/F12170E/2016(H9N2)) segment 6 neuraminidase (NA) gene

42


KY558844.1 Influenza A virus (A/chicken/Egypt/F12505E/2016(H5N1)) segment 4 hemagglutinin (HA) gene

43


KY558843.1 Influenza A virus (A/chicken/Egypt/N12640A/2016(H5N1)) segment 6 neuraminidase (NA) gene,

44

2017

El-Shesheny,R., Mostafa,A., Kandeil,A., Mahmoud,S.H., Bagato,O.,Naguib,A., Refaey,S.E., Webby,R.J., Ali,M.A. and Kayali,G.

KX247645.1

Influenza A virus (A/Egypt/MOH-NRC-8434/2014(H5N1)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes,

45

2017


KX247644.1

Influenza A virus (A/Egypt/MOH-NRC-8434/2014(H5N1)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes

46

2017 El-Shesheny,R., Mostafa,A., Kandeil,A., Mahmoud,S.H.,

KX247643.1 Influenza A virus (A/Egypt/MOH-NRC-8434/2014(H5N1)) segment 6

47










9

Bagato,O.,Naguib,A., Refaey,S.E., Webby,R.J., Ali,M.A. and Kayali,G.

neuraminidase (NA) gene

2017 El-Shesheny,R., Kandeil,A., Mahmoud,S., El Refaey,S., Kayali,G. and Ali,M.

KX247642.1 Influenza A virus (A/Egypt/MOH-NRC-8434/2014(H5N1)) segment 5 nucleocapsid protein (NP) gene

48

2017


KX247641.1

Influenza A virus (A/Egypt/MOH-NRC-8434/2014(H5N1)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes,

49

2017

El-Shesheny,R., Mostafa,A., Kandeil,A., Mahmoud,S.H., Bagato,O.,Naguib,A., Refaey,S.E., Webby,R.J., Ali,M.A. and Kayali,G

KX247640.1

Influenza A virus (A/Egypt/MOH-NRC-8434/2014(H5N1)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes

50

2017


KX247639.1 Influenza A virus (A/Egypt/MOH-NRC-8434/2014(H5N1)) segment 1 polymerase PB2 (PB2) gene

51

2016 Gomaa,M., Kandeil,A., El Shesheny,R., Ali,M.A. and Kayali,G

KX097876.1 Influenza A virus (A/swine/Egypt/151/2015(H9N2)) segment 4 hemagglutinin (HA) gene

52



53



54



55



56



57



58



59



60



61



62

2016 Gomaa,M., Kandeil,A., El Shesheny,R., Ali,M.A. and

KX097881.1 Influenza A virus (A/swine/Egypt/94/2014(H5N1))

63

10

Kayali,G segment 4 hemagglutinin (HA) gene



64



65

2016 Kayali,G., El-Shesheny,R., Kandeil,A., Webby,R.J. and Ali,M.A.

KX000879.1 Influenza A virus (A/chicken/Egypt/F9883C/2014(H9N2)) segment 6 neuraminidase (NA) gene

66


KX000878.1 Influenza A virus (A/chicken/Egypt/D10566B/2015(H9N2)) segment 4 hemagglutinin (HA) gene

67


KX000877.1

Influenza A virus (A/chicken/Egypt/Q10429E/2014(H9N2)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes

68


KX000876.1 Influenza A virus (A/pigeon/Egypt/S10408B/2014(H9N2)) segment 1 polymerase PB2 (PB2) gene

69


KX000875.1 Influenza A virus (A/chicken/Egypt/D10561/2015(H9N2)) segment 6 neuraminidase (NA) gene

70


KX000874.1

Influenza A virus (A/chicken/Egypt/Q10429E/2014(H9N2)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes

71



72


KX000872.1 Influenza A virus (A/quail/Egypt/D10093/2014(H9N2)) segment 6 neuraminidase (NA) gene

73


KX000871.1 Influenza A virus (A/chicken/Egypt/D9817E/2014(H9N2)) segment 4 hemagglutinin (HA) gene

74


KX000870.1 Influenza A virus (A/chicken/Egypt/F9516B/2014(H9N2)) segment 1 polymerase PB2 (PB2) gene

75


KX000869.1

Influenza A virus (A/quail/Egypt/D9842/2014(H9N2)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes

76


KX000868.1 Influenza A virus (A/chicken/Egypt/D9326C/2013(H9N2)) segment 6 neuraminidase (NA) gene

77


KX000867.1

Influenza A virus (A/chicken/Egypt/F10993B/2015(H9N2)) segment 5 nucleocapsid protein (NP) gene

78


KX000866.1

Influenza A virus (A/pigeon/Egypt/S10408B/2014(H9N2)) segment 5 nucleocapsid protein (NP) gene

79

2016 Kayali,G., El-Shesheny,R., Kandeil,A., Webby,R.J. and

KX000865.1 Influenza A virus (A/quail/Egypt/D10106/2014(H9N2))

80

11

Ali,M.A. segment 4 hemagglutinin (HA) gene


KX000864.1 Influenza A virus (A/chicken/Egypt/C9742/2014(H9N2)) segment 4 hemagglutinin (HA) gene

81


KX000863.1 influenza A virus (A/chicken/Egypt/D10549D/2015(H9N2)) segment 4 hemagglutinin (HA) gene

82


KX000862.1 Influenza A virus (A/chicken/Egypt/D10707B/2015(H9N2)) segment 6 neuraminidase (NA) gene

83


KX000861.1 Influenza A virus (A/chicken/Egypt/D10705/2015(H9N2)) segment 4 hemagglutinin (HA) gene

84


KX000860.1 Influenza A virus (A/chicken/Egypt/F9883C/2014(H9N2)) segment 4 hemagglutinin (HA) gene

85


KX000859.1

Influenza A virus (A/pigeon/Egypt/S10408B/2014(H9N2)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes

86



87


KX000857.1 Influenza A virus (A/quail/Egypt/D9842/2014(H9N2)) segment 4 hemagglutinin (HA) gene

88


KX000856.1 Influenza A virus (A/chicken/Egypt/Q10429E/2014(H9N2)) segment 6 neuraminidase (NA) gene

89


KX000855.1

Influenza A virus (A/pigeon/Egypt/S10408B/2014(H9N2)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes

90



91


KX000853.1 Influenza A virus (A/chicken/Egypt/S10916B/2015(H9N2)) segment 4 hemagglutinin (HA) gene

92



93



94


KX000850.1 Influenza A virus (A/chicken/Egypt/F10285D/2014(H9N2)) segment 6 neuraminidase (NA) gene

95


KX000849.1

Influenza A virus (A/chicken/Egypt/Q10429E/2014(H9N2)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes

96


KX000848.1 Influenza A virus (A/chicken/Egypt/F10533D/2015(H9N2)) segment 6 neuraminidase (NA) gene

97

2016 Kayali,G., El-Shesheny,R., KX000847.1 Influenza A virus 98

12

Kandeil,A., Webby,R.J. and Ali,M.A.

(A/chicken/Egypt/F10993B/2015(H9N2)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes


KX000846.1 Influenza A virus (A/chicken/Egypt/A1093D/2015(H9N2)) segment 4 hemagglutinin (HA) gene

99



100



101


KX000843.1 Influenza A virus (A/chicken/Egypt/F10993B/2015(H9N2)) segment 6 neuraminidase (NA) gene

102


KX000842.1 Influenza A virus (A/chicken/Egypt/S10490/2015(H9N2)) segment 6 neuraminidase (NA) gene

103


KX000841.1

Influenza A virus (A/duck/Egypt/C9787/2014(H9N2)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes

104


KX000840.1 Influenza A virus (A/chicken/Egypt/D9817E/2014(H9N2)) segment 6 neuraminidase (NA) gene

105


KX000839.1 Influenza A virus (A/chicken/Egypt/S10939E/2015(H9N2)) segment 6 neuraminidase (NA) gene,

106


KX000838.1 Influenza A virus (A/chicken/Egypt/N10963/2015(H9N2)) segment 4 hemagglutinin (HA) gene

107


KX000837.1

Influenza A virus (A/pigeon/Egypt/S10408B/2014(H9N2)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes

108



109


KX000835.1

Influenza A virus (A/chicken/Egypt/F9516B/2014(H9N2)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes

110


KX000834.1

Influenza A virus (A/quail/Egypt/D10106/2014(H9N2)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes

111


KX000833.1


112


KX000832.1 Influenza A virus (A/chicken/Egypt/S10312C/2014(H9N2)) segment 6 neuraminidase (NA) gene

113


KX000831.1 Influenza A virus (A/chicken/Egypt/F9516B/2014(H9N2)) segment 6 neuraminidase (NA) gene

114

13


KX000830.1 Influenza A virus (A/chicken/Egypt/Q10429E/2014(H9N2)) segment 4 hemagglutinin (HA) gene

115


KX000829.1 Influenza A virus (A/chicken/Egypt/S9668D/2014(H9N2)) segment 6 neuraminidase (NA) gene

116


KX000828.1

Influenza A virus (A/pigeon/Egypt/S10409A/2014(H9N2)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes

117


KX000827.1 Influenza A virus (A/quail/Egypt/D10106/2014(H9N2)) segment 1 polymerase PB2 (PB2) gene

118


KX000826.1

Influenza A virus (A/quail/Egypt/D10106/2014(H9N2)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes

119


KX000825.1

Influenza A virus (A/chicken/Egypt/F10993B/2015(H9N2)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes

120



121


KX000823.1 Influenza A virus (A/chicken/Egypt/S9652E/2014(H9N2)) segment 4 hemagglutinin (HA) gene,

122



123



124


KX000820.1 Influenza A virus (A/chicken/Egypt/D10706E/2015(H9N2)) segment 6 neuraminidase (NA) gene

125


KX000819.1


126


KX000818.1

Influenza A virus (A/quail/Egypt/D10093/2014(H9N2)) segment 5 nucleocapsid protein (NP) gene

127



128



129



130


KX000814.1 Influenza A virus (A/chicken/Egypt/A10588/2015(H9N2)) segment 4 hemagglutinin (HA) gene

131

14



132


KX000812.1 Influenza A virus (A/chicken/Egypt/S10598E/2015(H9N2)) segment 6 neuraminidase (NA) gene

133


KX000811.1 Influenza A virus (A/pigeon/Egypt/S10408B/2014(H9N2)) segment 6 neuraminidase (NA) gene

134


KX000810.1


135


KX000809.1


136


KX000808.1 Influenza A virus (A/chicken/Egypt/F10533A/2015(H9N2)) segment 6 neuraminidase (NA) gene

137


KX000807.1 Influenza A virus (A/chicken/Egypt/S10916B/2015(H9N2)) segment 6 neuraminidase (NA) gene

138


KX000806.1

Influenza A virus (A/pigeon/Egypt/S10409A/2014(H9N2)) segment 5 nucleocapsid protein (NP) gene

139



140


KX000804.1 Influenza A virus (A/duck/Egypt/C9787/2014(H9N2)) segment 1 polymerase PB2 (PB2) gene

141


KX000803.1 Influenza A virus (A/chicken/Egypt/S9348B/2014(H9N2)) segment 6 neuraminidase (NA) gene

142


KX000802.1 Influenza A virus (A/chicken/Egypt/N10963/2015(H9N2)) segment 6 neuraminidase (NA) gene

143


KX000801.1 Influenza A virus (A/chicken/Egypt/F10528A/2015(H9N2)) segment 4 hemagglutinin (HA) gene

144


KX000800.1

Influenza A virus (A/quail/Egypt/D10105/2014(H9N2)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes

145


KX000799.1 Influenza A virus (A/chicken/Egypt/Q9394E/2014(H9N2)) segment 6 neuraminidase (NA) gene

146



147


KX000797.1 Influenza A virus (A/chicken/Egypt/D9326C/2013(H9N2)) segment 4 hemagglutinin (HA) gene

148


15


(A/chicken/Egypt/D10562/2015(H9N2)) segment 6 neuraminidase (NA) gene


KX000795.1 Influenza A virus (A/chicken/Egypt/C9742/2014(H9N2)) segment 6 neuraminidase (NA) gene

150


KX000794.1 Influenza A virus (A/chicken/Egypt/S10489C/2015(H9N2)) segment 4 hemagglutinin (HA) gene

151



152


KX000792.1 Influenza A virus (A/chicken/Egypt/S10598E/2015(H9N2)) segment 4 hemagglutinin (HA) gene

153


KX000791.1 Influenza A virus (A/chicken/Egypt/F10993B/2015(H9N2)) segment 4 hemagglutinin (HA) gene

154


KX000790.1 Influenza A virus (A/quail/Egypt/D10093/2014(H9N2)) segment 4 hemagglutinin (HA) gene

155


KX000789.1 Influenza A virus (A/pigeon/Egypt/S10408B/2014(H9N2)) segment 4 hemagglutinin (HA) gene

156


KX000788.1 Influenza A virus (A/chicken/Egypt/N10957A/2015(H9N2)) segment 6 neuraminidase (NA) gene

157


KX000787.1 Influenza A virus (A/chicken/Egypt/Q10649C/2015(H9N2)) segment 6 neuraminidase (NA) gene

158



159


KX000785.1

Influenza A virus (A/pigeon/Egypt/S10409A/2014(H9N2)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes

160


KX000784.1 Influenza A virus (A/quail/Egypt/D10105/2014(H9N2)) segment 1 polymerase PB2 (PB2) gene

161


KX000783.1

Influenza A virus (A/chicken/Egypt/F10993B/2015(H9N2)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes

162


KX000782.1 Influenza A virus (A/chicken/Egypt/D10798D/2015(H9N2)) segment 6 neuraminidase (NA) gene

163


KX000781.1 Influenza A virus (A/chicken/Egypt/N10957A/2015(H9N2)) segment 4 hemagglutinin (HA) gene

164


KX000780.1

Influenza A virus (A/quail/Egypt/D10105/2014(H9N2)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes, complete cds

165


KX000779.1 Influenza A virus (A/pigeon/Egypt/S10408B/2014(H9N2))

166

16

Ali,M.A. segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes, complete cds


KX000778.1

Influenza A virus (A/pigeon/Egypt/S10409A/2014(H9N2)) segment 6 neuraminidase (NA) gene, complete cds

167


KX000777.1

Influenza A virus (A/chicken/Egypt/D10799A/2015(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

168


KX000776.1

Influenza A virus (A/chicken/Egypt/F9516B/2014(H9N2)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes, complete cds

169


KX000775.1

Influenza A virus (A/chicken/Egypt/Q10660B/2015(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

170


KX000774.1

Influenza A virus (A/chicken/Egypt/D10549D/2015(H9N2)) segment 6 neuraminidase (NA) gene, complete cds

171


KX000773.1

Influenza A virus (A/chicken/Egypt/S9288A/2013(H9N2)) segment 6 neuraminidase (NA) gene, complete cds

172


KX000772.1

Influenza A virus (A/quail/Egypt/D10093/2014(H9N2)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes, complete cds

173


KX000771.1

Influenza A virus (A/quail/Egypt/D9842/2014(H9N2)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes, complete cds

174


KX000770.1

Influenza A virus (A/chicken/Egypt/D10562/2015(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

175


KX000769.1

Influenza A virus (A/chicken/Egypt/F10993B/2015(H9N2)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes, complete cds

176


KX000768.1

Influenza A virus (A/chicken/Egypt/S9652E/2014(H9N2)) segment 6 neuraminidase (NA) gene, complete cds

177


KX000767.1

Influenza A virus (A/duck/Egypt/C9787/2014(H9N2)) segment 5 nucleocapsid protein (NP) gene, complete cds

178


KX000766.1 Influenza A virus (A/chicken/Egypt/D10685D/2015(H9N2))

179

17

Ali,M.A. segment 4 hemagglutinin (HA) gene, complete cds


KX000765.1

Influenza A virus (A/chicken/Egypt/F9516B/2014(H9N2)) segment 5 nucleocapsid protein (NP) gene, complete cds

180


KX000764.1

Influenza A virus (A/pigeon/Egypt/S10409A/2014(H9N2)) segment 1 polymerase PB2 (PB2) gene, complete cds

181


KX000763.1

Influenza A virus (A/chicken/Egypt/F10534C/2015(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

182


KX000762.1

Influenza A virus (A/chicken/Egypt/F9516B/2014(H9N2)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes, complete cds

183


KX000761.1

Influenza A virus (A/chicken/Egypt/Q10660B/2015(H9N2)) segment 6 neuraminidase (NA) gene, complete cds

184


KX000760.1

Influenza A virus (A/chicken/Egypt/S10312C/2014(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

185


KX000759.1

Influenza A virus (A/chicken/Egypt/A10588/2015(H9N2)) segment 6 neuraminidase (NA) gene, complete cds

186


KX000758.1

Influenza A virus (A/chicken/Egypt/S9645/2014(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

187


KX000757.1

Influenza A virus (A/chicken/Egypt/S10489C/2015(H9N2)) segment 6 neuraminidase (NA) gene, complete cds

188


KX000756.1

Influenza A virus (A/chicken/Egypt/D10700/2015(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

189


KX000755.1

Influenza A virus (A/duck/Egypt/C9787/2014(H9N2)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes, complete cds

190


KX000754.1

Influenza A virus (A/chicken/Egypt/S9668D/2014(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

191


KX000753.1

Influenza A virus (A/chicken/Egypt/F10528A/2015(H9N2)) segment 6 neuraminidase (NA) gene, complete cds

192


18


(A/chicken/Egypt/Q10429E/2014(H9N2)) segment 1 polymerase PB2 (PB2) gene, complete cds


KX000751.1

Influenza A virus (A/duck/Egypt/C9787/2014(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

194


KX000750.1

Influenza A virus (A/chicken/Egypt/S10939E/2015(H9N2)) segment 4 hemagglutinin (HA) gene, complete cds

195


KX000749.1

Influenza A virus (A/chicken/Egypt/N10975/2015(H9N2)) segment 6 neuraminidase (NA) gene, complete cds

196

19

Patents

طالب البراءة تاريخ اإليذاع رقن الطلب تسويت البراءة م

استحذاث ساللت لقاح انفلونزا 1

هنخفضت H5N1الطيور

الضراوة هن العزالث الوصريت

شذيذة الضراوة باستخذام

تكنولوجيا الوراثت العكسيت

الوركز القوهي للبحوث 8/5/7117 787/7117

اعذاد لقااح انفلاونزا الطياور ناوع 7

H5N8 هاان الوعاازوالث الوصااريت

و تقيوت هناعيا

1978/7117 71/11/7117 الوركز القوهي للبحوث

Prizes

الجوائز التى حصل عليها الفريق البحثى خالل العمل بالمشروع

عام الجهة المانحة الجائزة االسم

رابح عبد الحق محمد عبد الفتاح الشيشيني

2016 المركز القومً للبحوث جائزة المركز للتشجٌع العلمً

2016 اكادٌمٌة البحث العلمً جائزة الدولة التشجعٌة السيداحمد مصطفى محمد

جائزة الهٌئات و االفراد"دكتور احمد مصطفى محمد السيد محمد الصبان"

2017 اكادٌمٌة البحث العلمً

افضل نشر علمً لمساعدي البحاث مختار رزق موسي العلوم الطبٌة

2016 المركز القومً للبحوث

محمود محمد مصطفي شحاتة

افضل نشر علمً لمساعدي البحاث العلوم التكنولوجٌة


افضل نشر علمً لمساعدي البحاث احمد السيد قايد بحوث البٌئة


20

Training

تدريب باحثين من خارج مصر:

تم تدرٌب السادة اآلتى أسماؤهم :

Funded Agent Home Institute Country Name

FAO,Ethiopia National Animal Health Diagnostic

and Investigation Centre

(NAHDIC),Ethiopia

Ethiopia Ayelech Mulunbh

FAO,Ethiopia National Animal Health Diagnostic

and Investigation Centre

(NAHDIC),Ethiopia

Ethiopia Melaku Sombo

NRC بىك الجيىاث والتتابعاث الىراثيت بمركز الدوا

العادلى للبحث والتدريب بجامعه الىهريه بالعراق وادرة سلمان محمد العراق

تدريب باحثين من الداخل:

الدرجة العلمية الجهة الموفد منها أسم المتدرب م

جامعة مصر للعلوم-كلٌة البٌوتكنولوجى أحمد عبد العال 1 الرابعة طالب بالفرقة

طالب بالفرقة الرابعة مركز بحوث الصحة الحٌوانٌة محمد حسن 2

جامعة مصر للعلوم-كلٌة البٌوتكنولوجى نٌرفانا محمد 3 طالب بالفرقة الرابعة

طالب بالفرقة الرابعة جامعة مصر للعلوم-كلٌة البٌوتكنولوجى نوران ٌحى 4

للعلوم جامعة مصر-كلٌة البٌوتكنولوجى مدحت محمد حسن 5 طالب بالفرقة الرابعة

طالب بالفرقة الرابعة معهد بحوث وأنتاج اللقاحات البٌطرٌة خلٌل أحمد على 6

طالب بالفرقة الرابعة جامعة القاهرة -قسم البٌوتكنولوجى مٌنا نبٌل 7

جامعة القاهرة -قسم البٌوتكنولوجى أالء أسامة حسن 8 طالب بالفرقة الرابعة

جامعة القاهرة -قسم البٌوتكنولوجى أبراهٌمأسماء سعٌد 9 طالب بالفرقة الرابعة

جامعة القاهرة -قسم البٌوتكنولوجى أٌة مدحت شاكر 11 طالب بالفرقة الرابعة

جامعة القاهرة -قسم البٌوتكنولوجى خلود خالد أحمد 11 طالب بالفرقة الرابعة

جامعة القاهرة -قسم البٌوتكنولوجى أسراء الباز 12 طالب بالفرقة الرابعة

جامعة القاهرة -قسم البٌوتكنولوجى مى محمود شوكت 13 طالب بالفرقة الرابعة

جامعة القاهرة -قسم البٌوتكنولوجى دٌفٌد وجٌه أدٌب 14 طالب بالفرقة الرابعة

جامعة القاهرة -قسم البٌوتكنولوجى مدحت محمد حسن 15 طالب بالفرقة الرابعة

21

Post-graduates

الرسائل العلمية

و قد قام الطالب باجراء الشق العملي في مركز تم منحهاالتي رسائل قائمة بالأ.

: التميز العلمي لفيروسات االنفلونزا

No. Degree Student

Name Title Faculty University

Date of

Submission

Date of

Approval

1 M.Sc. محمد عبد أمنٌة

العزٌز

Evaluation of avian

influenza H5N1 plasmid-

based inactivated Egyptian

vaccines and treatment with

antivirus drugs.

Pharmacy Cairo 2010 2116

2 M.Sc. محمد عال

منصور

Molecular Basis of

influenza A virus sensitivity

to commercial drugs:

screening for novel antiviral

compounds.

Science Cairo 2014 2016

3 M.Sc. محمد ٌاسمٌن

معتصم

Possible reassortment

between highly pathogenic

H5N1 and low pathogenic

H9N2 avian influenza

viruses and its impact on

pathogenicity and

infectivity.

Science

Biotech.

Cairo 2014 2017

4 M.Sc. رزق مختار

موسى

Seroprevalence of Avian

influenza subtyps H7 and

H9 among Egyptian

farmers.

Azhar

Science

Azhar 2012 2016

5 Ph.D. نٌفٌن مجدي

رزق محمد

Possible transmission of

Avian influenza A virus

(H5N1) via some aquatic

animals.

Science Ain

Shams

2010 2116

6 M.D. محمد ٌس على

دروٌش

A Study of Community

acquired viral pneumonia in

children.

Medicine Ain

Shams

2010 2017

22

باجراء الشق العملي في مركز التميز المسجلة ويقوم الطالب ب. قائمة بالرسائل

العلمي لفيروسات االنفلونزا

No. Degree Student Name

Title Faculty University Date of Submission

1 Ph.D. محمود محمد مصطفى شحاته

Development of MERS CoV vaccine using predicted immunogenic coding peptides transformed in carrier viruses

Science Ain Shams 2014

2 Ph.D. احمد السٌد محمد السٌد قاٌد

Establishment of an active surveillance system to monitor avian influenza viruses circulating among wild birds in Egyptian environment

Agriculture Cairo 2016

3 Ph.D. مختار رزق موسى

Effectiveness of the control strategies for influenza A viruses among Egyptian population: An active surveillance based study


4 Ph.D. محمد عبد أمنٌة العزٌز

Novel approaches to develop targeted antiviral compounds based on structural proteins of influenza viruses

Pharmacy Cairo 2018

5 Ph.D. محمد منصور عال Genetic and antigenic characterization of Influenza B viruses in Egypt and assessment of vaccine efficency

Science Cairo 2017

6 Ph.D. محمد ٌاسمٌن معتصم

Molecular approaches to study genetic characteristics, pathobiological features and control strategies of Avian influenza H5N8 virus

Science Cairo 2017

7 Ph.D. سارة حسٌن محمود

Evolution of Avian Influenza viruses in Egypt towards Mammals: In silico Prediction and experimental confirmation

Agriculture Cairo 2016

8 Ph.D. فرج أحمد ناجح الطوٌل

Zoonotic Potential of Astroviruses in Bats and Migratory birds


9 M.SC. محمد عبد الفتاحعبد العزٌز جاب

هللا

Screening for antiviral bioactivity of water extracts from some medicinal and edible plants

Science Al-Azhar 2017

ثوحبلل ىموقلا زكرملا center of scientific excellence for influenza ... · center...

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