排尿障礙治療中心 版權所有 dysfunctional voiding in children hann-chorng kuo department...
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排尿障礙治療中心 版權所有
Dysfunctional Voiding in Children
Hann-Chorng KuoDepartment of Urology
Buddhist Tzu Chi General Hospital
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排尿障礙治療中心 版權所有
Development ofUrethral Sphincter Specific striated sphincter muscle closely a
pplied to the smooth muscle at membranous urethra and mid-urethra
A ring shape sphincter in early adolescence, which account for initial high voiding pressure in infancy and early vesicoureteral reflux
An omega shape shincter in adolescence after development of urogenital septum
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排尿障礙治療中心 版權所有
Congenital Abnormalities Myelodysplasia Lipomeningocele Sacral agenesis Tethered cord Cerebral palsy Bladder extrophy Posterior urethral valve Anorectal malformations
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排尿障礙治療中心 版權所有
Myelomeningocele The most common form of NVD in children Early detection and folic acid treatment ma
rkedly decrease spinal defects Upper and lower motor bladder dysfunctio
n and pelvic floor dysfunction may occur in thoracic or sacral lesions
Early prophylactic treatment of DESD by CIC, anticholinergics are beneficial
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排尿障礙治療中心 版權所有
Myelomeningocele, detrusor areflexia and incontinence
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排尿障礙治療中心 版權所有
Meningomyelocele & Bilateral VUR & Recurrent UTI
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排尿障礙治療中心 版權所有
Lipomeningocele Difficult to identify by physical examination,
MRI is the best diagnostic method Intradural lipoma results in disease and pre
sentation The most common urodynamic findings are
consistent with an upper motor neuron lesion
DESD is less common Detrusor hyperreflexia and areflexia can be
found in this group of lesion
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排尿障礙治療中心 版權所有
Sacral agenesis Often discovered at older children with
incontinence Loss of the lower vetebral bodies by X-r
ay or MRI Patients have stable neurological lesio
n Patients may have no signs of denervat
ion, hyperreflexia, areflexia, intact sphincter, sphincter dyssynergia
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排尿障礙治療中心 版權所有
Tethered cord syndrome Most commonly seen in patients after
surgery for myelomeningocele Isolated tethered cord is less common Severe bladder dysfunction and refrac
tory incontinence may occur Surgical division of the filum may imp
rove symptoms
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排尿障礙治療中心 版權所有
Cerebral Palsy Develops most commonly in premature infa
nt Infection and anoxia result in a non-progres
sive brain lesion and muscular disability Continence is often delayed to develop but
intact Uninhibited detrusor contractions without
DESD is the most commonly urodynamic finding
Pseudodyssynergia may occur
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排尿障礙治療中心 版權所有
Cerebral palsy with frequency dysuria due to DI
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排尿障礙治療中心 版權所有
Bladder extrophy Characterized by extrophic bladder, abdom
inal wall defect, epispadias, pelvic diastasis, VU reflux, inguinal hernia
Staged reconstruction by abdominal wall closure, epispadias repair, bladder neck reconstruction and correction of VUR
Improved pelvic floor reconstruction after osteotomy has better continence rate
Bladder augmentation may be indicated
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排尿障礙治療中心 版權所有
Posterior Urethral Valve The most common cause of BOO in newborn Present with incontinence and recurrent UTI Severe PUV may be detected antenatally, mild
form is found in older children Bilateral hydroureter and hydronephrosis may
develop in severe form of valve disease Transurethral ablation of valve resumes norm
al bladder but bladder function depends Anticholinergics, CIC and augmentation by ure
ter may be indicated
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排尿障礙治療中心 版權所有
Anorectal Malformations Rare congenital lesions of cloaca Associated with congenital GU abnormalitie
s in 20% with low and 60% high lesions,VUR, NVD, renal agenesis, renal dysplasia, cryptorchidism
Urethrorectal fistula may develop at at high, intermediate or low level
Neurogenic voiding dysfunction in 50% Tethered cord is the main vertebral abnorm
ality, which account for NVD
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排尿障礙治療中心 版權所有
Dysfunctional Voiding A group of neurologically intact children pre
sents with incontinence, dysuria, large residual urine, recurrent UTI, unilateral or bilateral hydronephrosis
Urodynamically classified into small capacity hypertonic bladder, detrusor hyperreflexia, lazy bladder syndrome,non-neurogenic neurogenic bladder
Treatment bases on interaction of bladder and external sphincter
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排尿障礙治療中心 版權所有
Patient evaluation – history Antenatal GU abnormalities – hydronephrosi
s, enlarged bladder, open spinal cord defect Past surgical history – detethering procedure,
VP shunt, urinary diversion Occurrence of UTI and antibiotics Bowel habit, fecal incontinence, and stool so
fteners Catheterization schedule, urine amount Medication and adverse effects
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排尿障礙治療中心 版權所有
Physical examination Neurological examination – gait, discr
imination of extremities, motor strength, DTR (S1,2), BCR (S2-4)
Sacral dimple, hair patch, lipoma Enlarged bladder Vincent curtsey Anal tone, volitional contraction of pe
lvic floor muscles
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排尿障礙治療中心 版權所有
Urodynamic study Estimated bladder capacity: (age+2)x30 ml Infusion rate: 10% of capacity Catheter: <6Fr intraurethral dual channel ca
theter, suprapubic catheter is preferable for pressure flow study
Abdominal pressure by rectal catheter Pelvic floor EMG – surface or needle Measuring bladder compliance, detrusor pr
essure, and EMG activities coordination
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排尿障礙治療中心 版權所有
Detrusor external sphincter dyssynergia (DESD) Type 1: Onset of EMG activity with initiation o
f voiding Type 2: intermittent inappropriate external sp
hincter contraction during voiding,which causes a reflex inhibition of detrusor contraction
Type 3: Persistent increased EMG activity during filling and voiding phases, which causes large residual urine and incontinence
Pseudodyssynergia: presence of urodynamic DESD in neurologically intact patient
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排尿障礙治療中心 版權所有
Leak-point pressures Detrusor leak-point pressure (DLPP): The de
trusor pressure causing urinary leakage per urethrum in the absence of detrusor contractions
A DLPP of more than 40 cm water has a risk of upper tract deterioration
Valsalvar LPP (VLPP): Assessing urethral resistance by abdominal straining, a VLPP <60 cm water indicates intrinsic sphincter deficiency
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排尿障礙治療中心 版權所有
Indications for urodynamic study in children Spinal dysraphisms Spinal cord injury Cerebral palsy with voiding dysfunction Sacral agenesis Imperforated anus Diurnal enuresis Suspicious voiding dysfunction and UTI Dysfunctional voiding
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排尿障礙治療中心 版權所有Urodynamic studies in children with dysfunctional voiding Uroflowmetry with surface EMG Cystometry with abdominal pressure
and EMG Pressure flow study recording Pves,Pa
bd, Pdet, EMG activity, and uroflowmetry
Videourodynamic study by suprapubic catheter or intra-urethral catheter
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排尿障礙治療中心 版權所有
Uroflowmetry – flat flow pattern with non-relaxing ES
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排尿障礙治療中心 版權所有
Uroflowmetry – Staccato pattern and poor relaxing ES
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排尿障礙治療中心 版權所有
Videourodynamics via cystostomy pressure flow study
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排尿障礙治療中心 版權所有
Dysfunctional VoidingAssociated with the followings Diurnal enuresis Urinary urgency Urinary frequency Constipation Urinary tract infection Vesicoureteral reflux
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排尿障礙治療中心 版權所有
Pathogenesis of dysfunctional voiding Increased voiding pressure during voiding
with contraction of the urethral sphincter Dysfunctional bowel evacuation and consti
pation Treatment directed at urodynamic abnorm
alities reduce the incidence of breakthrough UTI and increase resolution of vesicoureteral reflux
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排尿障礙治療中心 版權所有
Typical spinning top voiding cystourethrography
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排尿障礙治療中心 版權所有
Development of dysfunctional voiding Long-standing pelvic floor dysfunctio
n results in paradoxical sphincter contraction
Pelvic laxity Inappropriate stimulation of guarding
reflex results in inhibition of detrusor contraction
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排尿障礙治療中心 版權所有Detrusor instability without dyssynergic external sphincter
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排尿障礙治療中心 版權所有
Dysfunctional voiding and Urinary tract infection Elevated postvoid residual urine Host resistance – ability of bladder to
wash out pathogens Well hydration, void with strong strea
m, and complete voiding are important in prevention of UTI
Treatment aims at relaxation of the pelvic floor rather than the bladder
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排尿障礙治療中心 版權所有
Recurrent UTI in siblings with Dysfunctional voiding
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排尿障礙治療中心 版權所有
Non-neurogenic neurogenic bladder– Hinman syndrome The severest form of dysfunctional voi
ding Symptom complex including nocturn
al enuresis, diurnal enuresis, constipation, encopresis, UTI, and upper tract dilatation
Uninhibited detrusor contractions and dyssynergic external sphincter
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排尿障礙治療中心 版權所有
Treatment of non-neurogenic neurogenic bladder Voiding retraining Biofeedback Anticholinergic therapy Hypnosis Psychotherapy Management of constipation Antibiotics Clean intermittent catheterization
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排尿障礙治療中心 版權所有
Dysfunctional voiding and Vesicoureteral reflux Play a major role in etiology of
congenital VUR Important in development of VUR in
older child without congenital VUR Responsible for reflux exacerbation
and renal scarring Therapy to VUR should aim at
correction of dysfunctional voiding
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排尿障礙治療中心 版權所有
Bilateral VUR in a girl with Dysfunctional voiding
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排尿障礙治療中心 版權所有
Right VUR and DI without dysfunctional voiding
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排尿障礙治療中心 版權所有
Resolution of VUR after Anticholinergic therapy
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排尿障礙治療中心 版權所有
Urodynamic studies in infants High voiding pressures (160cm water)
with low bladder capacity in infant with gross dilating reflux
Voiding pressure in infant without reflux is 80 cm water
By age 2 years, voiding pressure diminished (70 cm water) and capacity increased, but unstable detrusor remain
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排尿障礙治療中心 版權所有
High voiding pressures in infancy Transient functional bladder outlet
obstruction Boys with high grade reflux have dilated
posterior urethra Higher voiding pressure is seen in
children with grades IV and V reflux Normalization of voiding pressures
explains high rate of reflux resolution in childhood
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排尿障礙治療中心 版權所有
Urodynamic studies in older children Up to 60% of children with reflux have
urodynamic abnormality Detrusor overactivity and sphincter d
yscoordination Primary sphincter overactivity is more
associated with high grade reflux and renal scarring
Bladder instability improves over time
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排尿障礙治療中心 版權所有
Pitfalls in urodynamic study in infants and children Poor cooperation of patient Appropriate size of intra-urethral cathet
er – 3 Fr, 5 Fr, 7 Fr? Frequent increased abdominal pressure Different infusion rate and compliance i
n different age Differential diagnosis of volitional voidi
ng and detrusor overactivity
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排尿障礙治療中心 版權所有
Urodynamics and Clinical course of VUR Treatment of detrusor overactivity with anti
cholinergics improves resolution or improvement in VUR than stable bladders
A higher surgery rate in stable bladder with VUR
Controversy remains in correlation of urodynamic abnormalities with grades of VUR and anticholinergic treatment with resolution rate of VUR
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排尿障礙治療中心 版權所有
Resolution of VUR and improved DI after anticholinergic and CIC in myelomeningocele
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排尿障礙治療中心 版權所有
Dysfunctional elimination syndromes (DES) Children are both infrequent voiders and co
nstipated Associated with an increased risk of urinary
tract infection With or without reflux Incontinent day and night with fecal soiling Observed to engage in holding maneuver to
avoid urination and defecation
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排尿障礙治療中心 版權所有
DES – A learned habit A learned habit acquired during
toilet training Most often occur in girls Recurrent cystitis due to short
urethra and bladder colonization Congenital VUR or secondary VUR
due to these aberrant toilet training habits
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排尿障礙治療中心 版權所有
Breakthrough UTI and Dysfunctional voiding Girls with history of voiding dysfuncti
on have higher rates of breakthrough UTI (4 times more common in DES)
Unsuccessful surgical outcome was seen in children with DES
Adequate hydration, timed voiding, stool softeners, laxatives, as well as anticholinergics may be helpful
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排尿障礙治療中心 版權所有
Voiding dysfunction without UTI Children with mono-symptomatic enuresis
have a very low urodynamic abnormality VUR has been found in child with frequency
urgency and urinary incontinence without history of UTI
15% of children had positive urodynamic findings and 16% had renal scarring
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排尿障礙治療中心 版權所有Diurnal incontinence due to pelvic floor hypertonicity & DI
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排尿障礙治療中心 版權所有Urge incontinence in a girl with dysfunctional voiding & DI
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排尿障礙治療中心 版權所有Treatment of Dysfunctional voiding in Children Adequate hydration and timed voiding Stool softeners and laxatives Anticholinergics – Ditropan, tolterodine Biofeedback – pelvic floor relaxation, c
omputerized game Intermittent catheterization Antibiotics for recurrent UTI
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排尿障礙治療中心 版權所有Improved bladder compliance and DI after ditropan therapy in myelomeningocele
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排尿障礙治療中心 版權所有
Adequate hydration Provide adequate urine production an
d wash out effect of bladder Prevent constipation and reduce colo
nization of pathogen in perineum Reduce detrusor instability through di
lution of urine and decrease urine permeability into urothelium
Time voiding is required
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排尿障礙治療中心 版權所有
Medication for dysfunctional voiding Oxybutynin – effective in reducing detrusor
overactivity, side effects of mucosal dryness & constipation
Ditropan XL – elimination of peak drug effect and reduce adverse effects
Tolterodine – M3 anticholinergic Alpha-adrenergic blocker to reduce urethral
resistance Phenylpropanolamine, pseudoephedrine –
in ISD with incontinence ready for CIC
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排尿障礙治療中心 版權所有
Pelvic floor rehabilitation Identification of pelvic floor muscles Regular pelvic floor muscle exercises
provide adequate relaxation of pelvic floor including urethral sphincter
A synergistic voiding pattern can be achieved after rehabilitation
Combined with fluid and anticholinergic therapy
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排尿障礙治療中心 版權所有Biofeedback for pelvic floor muscle relaxation Correcting paradoxical contractions of pelvi
c floor and urinary sphincter muscles with voiding
Success relies on motivation of children Uroflow- surface EMG integrated biofeedback
Cystometry biofeedback to inhibit detrusor overactivity in patients with DI
Visual or audio biofeedback may be more successful than verbal biofeedback
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排尿障礙治療中心 版權所有Biofeedback Pelvic floor muscle retraining
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排尿障礙治療中心 版權所有
Electrical stimulation to inhibit detrusor overactivity
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排尿障礙治療中心 版權所有
CMG biofeedback to inhibit Detrusor overactivty
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排尿障礙治療中心 版權所有Urethral injection of Botulinum A toxin in dysfunctional voiding New technique in reducing urethral re
sistance by paralyzing striated urethral sphincter
Intra-detrusor injection to reduce detrusor overactivity and increase bladder capacity
Restoration of normal voiding pattern Repeat injection may be necessary
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排尿障礙治療中心 版權所有
Botulinum A toxin (Botox)
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排尿障礙治療中心 版權所有
Reduction of MUCP after Botulinum A toxin injection
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排尿障礙治療中心 版權所有
Reduction of voiding pressure after Botulinum A toxin