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GmdSilmollb

The study of the effect of hydroalcoholic extract of Fumaria parviflora

on analgesic effect of morphine in Rat.

Alimohammad Maleki

In traditional medicine, it is suggested that Fumaria parviflora has analgesic

effect. In this study, the effect of hydroalcoholic extract of Fumaria parviflora on the

analgesic effect of morphine was investigated to lower the dose of morphine as

much as possible. This study was performed on rats by Tail flick Test

At first, analgesic effect of different doses of Fumaria Pam/lora extract (100,

200, 400, 600 and 800 mg/kg) were investigated separately. Then the influence of

these doses on the analgesic effect of suitable dose of morphine (2.5 mg/kg) were

recorded.

For performance of this study, each rat was placed in the restrainer and then

transferred to the Tail Flick set. The tail of the animal was placed in a special

groove of electrical eye, against lamp rays having an intensity of 51°C which was

produced by a set-lamp and the time of animal tail-taking reflex from electrical eye

was recorded automatically. In this study the cut off time was 10 seconds.

According to the results and using analytical variance method and Tukey Test,

the hest dose of extract for increasing the analgesic effect of morphine was

determined 400 mg/kg .The maximum analgesic effect of Fumaria panglora plus

morphine was observed withine 30 minutes of the test.

key words: Fumaria pang/0ra, Morphine, Pain, Tail flick, Rat.