백혈구 구조 , 기능 및 백혈구질환
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백혈구 구조 , 기능 및 백혈구질환. http://blog.naver.com/hyouncho2/60088163283. 백혈구 종류. Granulocyte : neutrophil, eosinoiphil, basophil Monocyte *mactophage histiocyte = tissue macrophage Lymphocyte *plasma cell. Differentiation of Myeloid Cells. - PowerPoint PPT PresentationTRANSCRIPT
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백혈구 구조 , 기능 및 백혈구질환
http://blog.naver.com/hyouncho2/60088163283
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Back to Basic백혈구 종류
Granulocyte : neutrophil, eosinoiphil, basophil Monocyte *mactophage histiocyte = tissue macrophageLymphocyte *plasma cell
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Pleuripotent stem cell (PST) → CFU-GEMM → CFU-GM → CFU-G →Myeloblast → promyelocyte → myelocyte → metamyelocyte → band neutophil → segmented neutrophil (eosinophil, basophil)
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Back to BasicMyeloid Pools (compartments)
Bone marrow : Stem cell pool: PSC – CFU-G Mitotic pool (5 ds ): myeloblast-myelocyte Post mitotic (reserve) pool (6.6 ds): metamyelocyte - seg.N Peripheral blood (9.5 hrs) : Circulating pool Marginated pool Tissue
http://blog.naver.com/hyouncho2/60105729162
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• Primary granules: myeloperoxidase, lactoferrin, leukocyte adhesion receptors, ALP, defensin, azurophil-derived bactericidal factor (ADBF)
• Secondary granules: lysozyme, collagenase, plasmin activator
• Tertiary granules : adhesion molecules, gelatinase, C3b receptor
• Surface membrane: CD11/CD18 complex, receptors for opsonin, chemotaxin, GM-CSF, G-CSF, phospholipid(PGE2, leukotriene, etc)
• Cytoplasm: actin, myosin, tubulin
과립구 ( 중성구 ) 구조
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Adhesion Cascade
중성구 살균 기능 - 관여물질
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Back to BasicPhagocytosis and Killing
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Back to Basic과립구 기능 이상
Defects of chemotaxis : aspirin, alcohol, corticosteroids, leukemias, lazy leucocyte syndrome
Defects of phagocytosis: lack of opsonization (hypogammaglobulinemia)
Defects of killing: chronic granulomatous disease (cytochrome b558 def), myeloperoxidase def.
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Back to Basic백혈구 수 (/mL) 변화
Neutrophilia : >7,500 Neutropenia : <1,500 Severe neutropenia : <500 Agranulocytosis : <100
Eosinophilia : 직접계산 ; 350 이상 , 백혈구 백분율로 환산 ; 500 이상 Basophilia : 200 이상 Monocytosis : 1,000 이상 Lymphocytosis : 성인 4,000 이상 , 소아 8,800 이상
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Back to BasicNeutrophilia
InfectionToxins: metabolic (uremia), drugs, chemicalsTissue destruction or necrosis: trauma, burns, myositis, vaculitis, infarction, neoplasiaMetabolic disorder : uremia, eclampsiaHemorrhage, especially into a body cavityRapid hemolysisHematologic disorders: leukemias, myeloproliferative neoplasmPseudoneutrophilia : physical stress, drugs
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Leukemoid reaction WBC>50,000, or immature cells in PB Granulocyte, Lymphocyte Severe inflammation or infection
Leukoerythroblastic reaction Immature granulocyte and erythroblast in PB Myelofibrosis, BM metastastic tumor, Massive bleeding or hemolysis,
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Pelger-Huet anomaly
May-Hegglin anomaly ; Dohle body
Chediak Higashi syndrome
Chronic granulomatous disease (CGD)
Myeloperoxidase deficiency
http://blog.naver.com/hyouncho2/60105739704
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Toxic granules & vacuoles
Dohle body
Hypersegmentation &
Macrocytic neutrophil
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Back to Basic중성구감소증 Neutropenia
Diseases that decrease neutrophil production ( 생산감소 )
• Aplastic anemia• Toxins that damage marrow• Collagen vascular diseases (such as SLE) • Myelphthisic marrow processes such as marrow
infiltration by infections or metastatic carcinomas)• Hematologic malignancies such as leukemias• Myeloproliferative disorders• Radiation therapy, Chemotherapy• Congenital disorders
Diseases that increase neutrophil destruction ( 파괴증가 )
• Splenomegaly with hypersplenism• Infection• Immune destruction
Pseudoneutropenia http://blog.naver.com/hyouncho2/60105693613
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Acute myeloid leukemia (AML) and related neoplasms Myelodysplastic syndromes (MDS) Myeloproliferative neoplasms (MPN)
Myelodysplastic–myeloproliferative neoplasms (MDS/MPN)
Myeloid/lymphoid neoplasms
associated with eosinophilia and abnormalities of
PDGFRA, PDGFRB, or FGFR1
http://blog.naver.com/hyouncho2/60142413658
http://blog.naver.com/hyouncho2/60109241833