5

1. 2.

2013/6/21*

5

1. 2. 2013/6/21*

Cancer Cancri Crab

p.s. 2013/6/21*

--- ---1.

2. 65

3.2013/6/21*

2013/6/21*

548 1122 1

557 (14,040) (11,023) (10,615) (9,655) (6,560)

31 201090,649 2012 43,665

350

(8,587) (8,116) (5,131)

2013/6/21*

2011

07441315 8161 111 2013/6/21*

() () (HBV, HCV, HPV)2013/6/21*

()

2013/6/21*

2013/6/21*

2013/6/21*

?2013/6/21*

() (), ,

1.() 2. :2013/6/21*

(/)2013/6/21*

precarcinogen/ ( free radical )carcinogeninitiated cellinitiation 12pre-neoplastic cellneoplastic cell promotion 10progression 1 --- 2013/6/21*

APC

K-rasp53DCC2013/6/21*

1. 2. 3.Aflatoxin4.AIDS(), B,C(HBV,HCV), HPV()5.6.7.8.

2013/6/21*

30-35%() 60%-70%2013/6/21*

2013/6/21*

1. 5

60% + 30~50% A + / 10~30% B / / 5% + 2%2013/6/21*

2. 2013/6/21*

3. 2013/6/21*

TNM Tumor Node MetastasisBCLCBarcelona Clinic Liver CancerTumor factorsnodularity Liver function Treatment modality FIGOInternational Federation of Gynecology and Obstetrics Stage 0, IA1, IA2 IB1, IB2, IIA, IIB, IIIA, IIIB, IVA, IVB 2013/6/21*

1990-1995102013/6/21*

1998199521.3953.847.259.421.935.615.7112.5421.813.628.010.513.226.1374.352.4114.425.140.036.0731.0470.735.1102.040.032.47.20150.382.2224.346.4104.44.823.2024.110.955.014.216.8179.15485.6324.1605.1180.1331.2167.62148.43210.1129.9311.4122.8132.6

35%1.

2.

3.

4. 2013/6/21*

84vs (88)2013/6/21*

1 4596360278.4 (81.1) 1 253337870.9 (65.2) 23 4217250359.4 (51.1) 34 2768140850.9 (40.6) 4569534349.4 (40.3) 56120253544.5 (30.2) 7772531643.6 (36.9) 68186679342.5 (10.9) 1494217162338.5 (24.9) 8103353118935.5 (12.7) 131197231532.4 (19.1) 1012103333232.1 (17.4) 111368821230.8 (10.6) 151488427230.8 (24.9) 91543613230.3 (14.8) 1216 251564125.5 (9.1) 16 30,70014,59447.5 (30.6)

? (20~30)

2013/6/21*

: 6090 12 5069 2134 12 IFOBT50 69 1533 35 43 :2013/6/21*

() : 4570404521 () : 301 () : 30 21 () : 50-6921 2013/6/21*

- (99-102) 992324982 (2.24.416)16100260%-89%19,5577,069 9815,0002.32013/6/21*

994379,605 ()30,087 () 30-69370% 45-69230% 302 50% 50-69250%

- (99-102) 2013/6/21*

CC View(Cephalic-Caudal View)MLO View(Medial-Lateral-Oblique View)2013/6/21*

BI-RADS : Breast Imaging Reporting and Data System Category 0 : Incomplete Category 1 : Negative Category 2 : Benign finding(s) Category 3 : Probably benign Category 4 : Suspicious abnormality Category 5 : Highly suggestive of malignancy Category 6 : Known biopsy proven malignancy2013/6/21*

Lt MLO View2013/6/21*

2013/6/21*

2013/6/21*

2013/6/21*

Cervical tumor Cervical Paps smear Cervical biopsy 30 3 2 ~ 32013/6/21*

1995 1 65 (HPV) (cervical dysplasia) 2013/6/21*

HPV 45 (CIN 3) 4 CIN 2 43% ~ 80%HPV 88% ~ 98.8%FDA2003 HPV 30 2013/6/21*

2013/6/21*

a meta-analysis of 4 randomized trial involving 320, 000 cases showed a 16% reduction in relative risk for CRC cancer death. The sensitivity of different fecal occult blood tests for cancer detection ranged from 37% to 79% in a study of about 8,000 candidates. (PET-CT) 2013/6/21*

2013/6/21*

5

1. 2. 2013/6/21*

Stopping Cancer Before It Starts ()-- 6070 3040 302013/6/21*

5

(BMI 18.5-24)2013/6/21*

1 579

2013/6/21*

2013/6/21*

2013/6/21*

1990 5-A-DAY Campaign 2013/6/21*

66% - 75% 75% 50% 30 - 40% 2013/6/21*

Low versus High Consumption of Fruit and Vegetable in the Risk of Cancer A review of 172 case-controlled prospective studiesCancer SiteProtection / StudiesRiskLung ()15 / 242.2Oral ()9 / 92.0Larynx ()4 / 42.3Esophagus ()15 / 162.0Stomach ()17 / 192.5Pancreas ()9 / 112.8Cervix ()7 / 82.0Colorectal ()20 / 351.9Breast ()8 / 141.8Prostate ()4 / 141.3Total 108 / 154 2013/6/21*

Dietary Phytochemicals 21

--- Phytochemicals are the vitamins --- of the twenty-first century

2013/6/21*

Phytochemicals

2013/6/21*

2013/6/21*

2 2013/6/21*

1. 2.3. 4.5.6.7.8.9. 1 2 32013/6/21*

333330130

2011.8.18 408153

2013/6/21*

2013/6/21*

/ (220-) x 50 ~ 60 %(220-) x 60 ~ 70 %(220-) x 70 ~ 80 %(220-) x 80 ~100 %

3

BMI 18.5-242013/6/21*

40 33 55

2013/6/21*

20127111851.135.8% 122013/6/21*

BMI Body Mass Index, BMI)/ 2()WHO BMI BMI (WHO, 2000)BMI 222013/6/21*

**

25-3030-3535-40

30/A500-10000.5-1.01000A______B30 / 581740 17405001240

**

*

4

20*

4000:1. 2. 3.4. 48

2013/6/21*

2010 1.35

2013/6/21*

201220%5/2013/6/21*

43665858719.7811618.6513111.8

937520102009

2010200914965563.252892659.95223589736.867533734.56731391824.367390625.26742327220.570333321.770521183812.947184613.247615173711.35414969.95376168010.856179711.9558514398.96914449.26898.12458.55211137.751102014038.47413398.47439757256.26038167253.560

90%!!

/2013/6/21*

15 : 85 :

15-242013/6/21*

1960

1981

1990 : 1. 2. ( ) 3. 4. 5.

2013/6/21*

105 ~ 7(,,, )2013/6/21*

85%~90%

512%~13% 2013/6/21*

20X2013/6/21*

0.3cm4000-6000X70%1cm1-2cm40060060-705-2020%MRI12cm3-5

5 2013/6/21*

--1. 2.3.4.5.6.2013/6/21*

11031061071091012102030400.1110111220.2//?2013/6/21*

DR70 () DR70? DR702013/6/21*

MRI PET

100% 95% 65% 25% 0%

#

/

5

2013/6/21*

2013/6/21*

****Regular physical activity.and may be beneficial for the prevention of other cancers as well including breast cancer.

*30**30500-10001000

*******