24

THE END

(hepatitis A virus, HAV)RNA(Picornaviridae) RNA(Hepatovirus)

() 20 RNA

() () HAV.() 601h100oC 5 pH 3

(hepatitis B virus, HBV)DNA(Hepadnaviridae)(Hepadnavirus)

() () 1. 2. (1) HAV IgM HAV IgGHAV (2) 3. (1) (2) RT-PCR

() HBV3 1.Dane HBsAgpre-S1pre-S2 20HBeAg DNA+DNA

2.22nmHBVHBsAgHBsAg3.22nm100700nm

S2SSSSPre-S1Pre-S2 CCCHBeAgHBcAgPDNAX154HBxAg() DNA2DNAHBV DNASCPXHBV

() ; ;() HAV 70 100 10

HBsAg

() () 1. 2. 3.

HBsAg: HBV a, d/y, w/r, adr -HBsHBcAg:Dane HBcIgGIgM eHBeAg: Dane HBe

HBsAgHBeAg-HBs-HBe-HBc+----HBV++---++--++--++--+++--++-----+--+--

(hepatitis C virus, HCV)(Flavivirdae)20~

() 4060nm RNA()

() HCV; HCV () HCV

HBV 4-8HCV HCV50%HCV

() () 1. 2. 1 HCVELISA 2 (strip immunoassay, SIA)(recombinant immunoblot assay, RIBA) 3. (1) RT-PCR (2) bDNA

(hepatitis D virus, HDV)(Arenaviridae) (Deltavirus)HBVDNA ()HBsAgHDVHBsAg35-37nmRNA

() 1.7Kb-ssRNA 9ORF() HDVHBV ()

HBsAg1.6%-5%HBsAgHBVHDV 1. (coinfection) HBV 2. (superinfection) HBVHDVHDV

() () 1. 2. 1HDV 2HDV IgM ELISA 3 HDV 3. RT-PCR

(hepatitis E virus, HEV)(Caliciviridae)(Calicivirus) () 3234nm RNA

() 7.5kb5-NCR-NS-S-NCR-Poly(A)- 33ORF () () HEV

2

() () 1. 2. ELISAHEV 3. RT-PCRHEV RNA

(hepatitis G virus, HGV) RNA9.5kbORFHBVHCV HGVRT-PCRELISA

(transfusion transmitted virus, TTV)DNA DNA3050nm 3.8kb2ORF TTVTTV TTV TV TTVPCRTTV DNA