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［別冊 平成２１年（２００９年）各研究分野業績発行物等一覧］ ＜分子遺伝研究分野＞ 「原著論文」

Takashi, Y., Kobayashi, Y., Tanaka, K. and Tamura, K.: Arabidopsis replication protein A 70a is required for DNA damage response and telomere length homeostasis. Plant Cell Physiol. 50, 1965–1976 (2009). Kawai-Yamada, M., Hori, Z., Ogawa, T., Ihara-Ohori, Y., Tamura, K., Nagano, M., Ishikawa, T. and Uchimiya, H.: Loss of calmodulin binding to Bax inhibitor-1 affects Pseudomonas- mediated hypersensitive response-associated cell death in Arabidopsis thaliana. J. Biol. Chem. 284, 27998–8003 (2009). ＜染色体動態研究分野＞ 「原著論文」 Kawashima, S. A., Yamagishi, Y., Honda, T., Ishiguro, K. and Watanabe, Y.: Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin. Science 327, 172-177 (2010). Tanaka, K., Chang, H. L., Kagami, A. and Watanabe, Y.: CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis. Dev. Cell 17, 334-343 (2009). Takemoto, A., Maeshima, K., Ikehara, T., Yamaguchi, K., Murayama, A., Imamura, S., Imamoto, N., Yokoyama, S., Hirano, T., Watanabe, Y., Hanaoka, F., Yanagisawa, J. and Kimura, K.: The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Nat. Struct. Mol. Biol. 16, 1302-1308 (2009). Sakuno, T., Tada, K. and Watanabe, Y.: Kinetochore geometry defined by cohesion within the centromere. Nature 458, 852-858 (2009).

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「総説」 丹野悠司、渡邊嘉典：姉妹染色分体のセントロメアにおける接着保護機構

蛋白質核酸酵素 54(4), 436-440 (2009)

山岸有哉、渡邊嘉典：ヘテロクロマチンがシュゴシンをセントロメアに繋ぎとめる 実験医学 27(13), 2113-2116 (2009)

作野剛士、渡邊嘉典：セントロメアでのコヒーシンによる接着を介した動原体

方向性の制御機構 蛋白質核酸酵素 54(14), 1842-1849 (2009) ＜核内情報研究分野＞ 「原著論文」 Sawatsubashi, S., Murata, T., Lim, J., Fujiki, R., Ito, S., Suzuki, E., Tanabe, M., Zhao, Y., Kimura, S., Fujiyama, S., Ueda, T., Umetsu, D., Ito, T., Takeyama, K. and Kato, S.: Histone chaperone DEK coactivates a nuclear receptor: a functional link to leukemia. Genes Dev. 24, 159-170 (2010). Ochiai, E., Kitagawa, H., Takada, I., Fujiyama, S., Sawatsubashi, S., Kim, M.-S., Mezaki, Y., Tshushima, Y., Takagi, K., Azuma, Y., Takeyama, K., Yamaoka, K., Kato, S. and Kamimura, T.: CDP/Cut is an osteoblastic co-activator of the vitamin D receptor (VDR). J. Bone Miner. Res. 2010, in press. Murai-Takeda, A., Shibata, H., Kurihara, I., Kobayashi, S., Yokota, K., Suda, N., Mitsuishi, Y., Jo, R., Kitagawa, H., Kato, S., Saruta, T. and Itoh, H.: NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor. J. Biol. Chem. 2010, in press. Son, B. K., Akishita, M., Iijima, K., Ogawa, S., Maemura, K., Yu, J., Takeyama, K., Kato, S., Eto, M. and Ouchi, Y.: Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification. J. Biol. Chem. 2010, in press. Nishikawa, K., Nakashima, T., Hayashi, M., Fukunaga, T., Kato, S., Kodama, T., Takahashi, S., Calame, K. and Takayanagi, H.: Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc. Natl. Acad. Sci. USA 107, 3117-3122 (2010). Koyama, S., Wada-Hiraike, O., Nakagawa, S., Tanikawa, M., Hiraike, H., Miyamoto, Y., Sone, K., Oda, K., Fukuhara, H., Nakagawa, K., Kato, S., Yano, T. and Taketani, Y.: Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem. Biophys. Res. Commun. 392, 357-362 (2010).

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Kim, M., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa H., Takeyama, K., Shibuya, H., Ohtake, F. and Kato, S.: DNA demethylation in hormone-induced transcriptional derepression. Nature 461, 1007-1012 (2009). Oya, H., Yokoyama, A., Yamaoka, I., Fujiki, R., Yonezawa, M., Youn, M.-Y., Takada, I., Kato, S. and Kitagawa, H.: Phosphorylation of WSTF by MAPK induces a switching between two distinct chromatin remodeling complexes. J. Biol. Chem. 284, 32472-32482 (2009). Fujiki, R., Chikanishi, T., Hashiba, W., Ito, H., Takada, I., Roeder, R. G., Kitagawa, H. and Kato, S.: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature 459, 455-459 (2009). Yamagata, K., Fujiyama, S., Ito, S., Ueda, T., Murata, T., Naitou, M., Takeyama, K., Minami, Y., O’Malley, B. W. and Kato, S.: Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol. Cell 36, 340-347 (2009). Zhao, Y., Takeyama, K., Sawatsubashi, S., Ito, S., Suzuki, E., Yamagata, K., Tanabe, M., Kimura, S., Fujiyama, S., Ueda, T., Murata, T., Matsukawa, H., Shirode, Y., Kouzmenko, A. P., Li, F., Tabata, T. and Kato, S.: Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system. Mol. Cell. Biol. 29, 1017-1034 (2009). Kouzu-Fujita, M., Mezaki, Y., Mtsumoto, T., Yamaoka, I., Sawatsubashi, S., Yano, T., Taketani, Y., Kitagawa, H. and Kato, S.: Co-activation of ERb by a gonadotropin-induced cofactor. Mol. Cell. Biol. 29, 83-92 (2009). Imai, Y., Kondoh, S., Kouzmenko, A. and Kato, S.: Regulation of bone metabolism by nuclear receptors. Mol. Cell. Endocrinol. 310, 3-10 (2009). Yoshimura, K., Kitagawa, H., Fujiki, R., Tanabe, M., Takezawa, S., Takada, I., Yamaoka, I., Yonezawa, M., Kondo, T., Furutani, Y., Yagi, H., Yoshinaga, S., Masuda, T., Fukuda, T., Yamamoto, Y., Ebihara, K., Li, D. Y., Matsuoka, R., Takeuchi, J. K., Matsumoto, T. and Kato, S.: Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). Proc. Natl. Acad. Sci. USA 106, 9280-9285 (2009). Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, A. P., Aigaki, T., Tabata, T., Takeyama, K. and Kato, S.: Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Proc. Natl. Acad. Sci. USA 106, 3818-3822 (2009).

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Imai, Y., Nakamura, T., Matsumoto, T., Takaoka, K. and Kato, S.: Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism. J. Bone Miner. Metab. 27, 127-130 (2009). Fujiyama-Nakamura, S., Ito, S., Sawatsubashi, S., Yamauchi, Y., Suzuki, E., Tanabe, M., Kimura, S., Murata, T., Isobe, T., Takeyama, K. and Kato, S.: BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Genes to Cells 14, 965-973 (2009). Ohtake, F., Fujii-Kuriyama, Y. and Kato, S.: AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions. Biochem. Pharmacol. 77, 474-484 (2009). Takada, I., Kouzmenko, A. P. and Kato, S.: Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat. Rev. Rheumatol. 5, 442-447 (2009). Takada, I., Kouzmenko, A. P. and Kato, S.: Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies. Expert Opin. Ther. Targets. 13, 593-603 (2009). Suzuki, H. I., Yamagata, K., Sugimoto, K., Iwamoto, T., Kato, S. and Miyazono, K.: Modulation of microRNA processing by p53. Nature 460, 529-533 (2009). Kawajiri, K., Kobayashi, Y., Ohtake, F., Ikuta, T., Matsushima, Y., Mimura, J., Pettersson, S., Pollenz, R. S., Sakaki, T., Hirokawa, T., Akiyama, T., Kurosumi, M., Poellinger, L., Kato, S. and Fujii-Kuriyama, Y.: Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc. Natl. Acad. Sci. USA 106, 13481-13486 (2009). Zhang, Z., Hener, P., Frossard, N., Kato, S., Metzger, D., Li, M. and Chambon, P.: Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc. Natl. Acad. Sci. USA 106, 1536-1541 (2009). Miyagawa, S., Satoh, Y., Haraguchi, R., Suzuki, K., Iguchi, T., Taketo, M. M., Nakagata, N., Matsumoto, T., Takeyama, K., Kato, S. and Yamada, G.: Genetic interactions of the androgen and Wnt/{beta}-catenin pathways for the masculinization of external genitalia. Mol. Endocrinol. 23, 871-880 (2009). Ikeda, Y., Aihara, K., Yoshida, S., Sato, T., Yagi, S., Iwase, T., Sumitomo, Y., Ise, T., Ishikawa, K., Azuma, H., Akaike, M., Kato, S. and Matsumoto, T.: Androgen-androgen receptor system protects against angiotensin II-induced vascular remodeling. Endocrinology 150, 2857-2864 (2009).

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Suzuki, K., Yamaguchi, Y., Villacorte, M., Mihara, K., Akiyama, M., Shimizu, H., Taketo, M. M., Nakagata, N., Tsukiyama, T., Yamaguchi, T. P., Birchmeier, W., Kato, S. and Yamada, G.: Embryonic hair follicle fate change by augmented beta-catenin through Shh and Bmp signaling. Development 136, 367-372 (2009). Iwasawa, M,, Miyazaki, T., Nagase, Y., Akiyama, T., Kadono, Y., Nakamura, M., Oshima, Y., Yasui, T., Matsumoto, T,. Nakamura, T., Kato, S., Hennighausen, L., Nakamura, K. and Tanaka, S.: The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice. J. Clin. Invest. 119, 3149-3159 (2009). Honzawa, S., Takahashi, N., Yamashita, A., Sugiura, T., Kurihara, M., Arai, M. A., Kato, S. and Kittaka, A.: Synthesis of a 1alpha-C-methyl analogue of 25-hydroxyvitamin D3: interaction with a mutant vitamin D receptor Arg274Leu. Tetrahedron 65, 7135-7145 (2009). Ishizawa, M., Iwasaki, K. I., Kato, S. and Makishima, M.: Hypergravity modulates vitamin D receptor target gene mRNA expression in mice. Am. J. Physiol. Endocrinol. Metab. 297, E728-734 (2009). Shiizaki, K., Hatamura, I., Imazeki, I., Moriguchi, Y., Sakaguchi, T., Saji, F., Nakazawa, E., Kato, S., Akizawa, T. and Kusano, E.: Improvement of impaired calcium and skeletal homeostasis in vitamin D receptor knockout mice by a high dose of calcitriol and maxacalcitol. Bone 45, 964-971 (2009). Tsuji, M., Yamamoto, H., Sato, T., Mizuha, Y., Kawai, Y., Taketani, Y., Kato, S., Terao, J., Inakuma, T., Takeda, E.: Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice. J. Bone Miner. Metab. 27, 673-681 (2009). ＜分子情報研究分野＞ 「原著論文」 Kawasaki, Y., Tsuji, S., Sagara, M., Echizen, K., Shibata, Y. and Akiyama, T.：APC and Asef function downstream of the HGF receptor and phosphatidylinositol 3-kinase. J. Biol. Chem. 284, 22436-22443 (2009). Kawasaki, Y., Tsuji, S., Muroya, K., Furukawa, S., Shibata, Y., Okuno, M., Ohwada, S. and Akiyama, T.：The APC-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+ mice. EMBO Rep. 10, 1355-1362 (2009). Sagara, M., Kawasaki, Y., Iemura, S. I., Natsume, T., Takai, Y., and Akiyama, T.：Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. Oncogene 28, 1357-1365 (2009).

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Kawajiri, K., Kobayashi, Y., Ohtake, F., Ikuta, T., Matsushima, Y., Mimura, J., Pettersson, S., Pollenz, R. S., Sakaki, T., Hirokawa, T., Akiyama, T., Kurosumi, M., Poellinger, L., Kato, S., and Fujii-Kuriyama, Y.：Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A. 106, 13481-13486 (2009). Niida, A., Smith, A. D., Imoto, S., Aburatani, H., Zhang, M. Q. and Akiyama T.：Gene set-based module discovery in the breast cancer transcriptome BMC Bioinformatics 10, 71 (2009). Yamazumi, Y., Kamiya, A., Nishida, A., Nishihara, A., Iemura, S., Natsume, T. and Akiyama, T.：The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes. Biochem. Biophys. Res. Commun. 389, 100-104 (2009). Kawasaki, Y., Jigami, T., Furukawa, S., Sagara, M., Echizen, K., Shibata, Y., Sato, R., and Akiyama, T.：The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. J. Biol. Chem. 285, 1199-1207 (2010). Niimi, R., Matsumine, A., Iino, T., Murata, T., Shintani, K., Nakazora, S., Nakamura, T., Uehara, Y., Kusuzaki, K., Akiyama, T., and Uchida, A.：The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas. Oncol Rep. 23, 631-638 (2010). Nakamura, T., Hayashi, T., Mimori-Kiyosue, Y., Sakaue, F., Matsuura, K., Iemura, S., Natsume, T. and Akiyama, T. ： The PX-RICS/14-3-3ζ/θ complex couples N-cadherin/β-catenin with Dynein/Dynactin to mediate its export from the endoplasmic reticulum. J. Biol. Chem. (in press). Roy, B. C., Kohno, T., Iwakawa, R., Moriguchi, T., Kiyono, T., Morishita, K., Sanchez-Cespedes, M., Akiyama, T. and Yokota, J.： Involvement of LKB1 in Epithelial-Mesenchymal Transition (EMT) of Human Lung Cancer Cells. Lung Cancer (in press). Taniue, K., Nishida, A., Hamada, F., Sugie, A., Oda, T., Ui-Tei, K., Tabata, T., and Akiyama, T.： Sunspot, a link between Wingless signaling and endoreplication in Drosophila. Development. 137, 1755-1764 (2010).

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＜情報伝達研究分野＞ 「原著論文」 Oishi K., Watatani K., Itoh Y., Okano H., Guillemot F., Nakajima K. and Gotoh Y.: Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1. Proc. Natl. Acad. Sci. U. S. A. 106, 13064-13069 (2009). Hirabayashi Y., Suzki N., Tsuboi M., Endo T.A., Toyoda T., Shinga J., Koseki H., Vidal M. and Gotoh Y.: Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron. 63, 600-613 (2009). Kuwahara A., Hirabayashi Y., Knoepfler P.S., Taketo M.M., Sakai J., Kodama T. and Gotoh Y.: Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex. Development. 137, 1035-1044 (2010). 「総説」 Miyata T., Kawaguchi D., Kawaguchi A. and Gotoh Y.: Mechanisms that regulate the number of neurons during mouse neocortical development. Curr. Opin. Neurobiol. 20, 22-28 (2010). 平林祐介、後藤由季子 : 大脳皮質においてニューロンの数を決定するメカニズム. 細胞工学、28, 45-49 (2009) 桑原篤、後藤由季子 : Wntシグナル. 炎症・再生事典、(2009) 川口大地、後藤由季子 ： 神経幹細胞の運命制御に関わるシグナル伝達. 最新医学、64, 1417-1425 (2009) 大西啓介、後藤由季子 : がん治療標的としての PI3K-Akt経路と JNK経路. 最新医学、64, 2176-2183 (2009) 平林祐介、後藤由季子 : ポリコーム複合体による神経系前駆細胞のニューロン分化能制御. 実験医学、28, 444-447 (2010) ＜細胞機能研究分野＞ 「原著論文」 Nagano, M., Ihara-Ohori, Y., Imai, H., Inada, N., Fujimoto, M., Tsutsumi, N., Uchimiya, H., and Kawai-Yamada, M.: Functional association of cell death suppressor, Arabidopsis Bax Inhibitor-1, with fatty acid 2-hydroxylation through cytochrome b5. Plant J. 26, 122-134 (2009). Takahashi, H., Munemura, I., Nakatsuka, T., Nishihara, M., and Uchimiya, H.: Metabolite Profiling by capillary electrophoresis-mass spectrometry reveals aberrant

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putrescine accumulation associated with idiopathic symptoms of gentian plants. J. Hort. Sci. Biotech. 84, 312-318 (2009). Sato, T., Kanda, K., Okawa, K., Takahashi, M., Watanabe, H., Hirano, T., Yaegashi, K., Sakamoto, Y., and Uchimiya, H.: The Tyrosinase-Encoding Gene of Lentinula edodes, Letyr, Is Abundantly Expressed in the Gills of the Fruit-Body during Post-Harvest Preservation. Biosci. Biotechnol. Biochem. 73, 1042-1047 (2009). Nakasone, A., Kawai-Yamada, M., Kiyosue, T., Narumi, I., Uchimiya, H., and Oono, Y.: A gene encoding SMALL ACIDIC PROTEIN2 potentially mediates the response to synthetic auxin, 2,4-dichlorophonoxyacetic acid, in Arabidopsis thaliana. J. Plant Physiol. 166, 1307-1313 (2009). Kasajima, I., Takahara, K., Kawai-Yamada, M., and Uchimiya, H.: Estimation of the Relative Sizes of Rate Constants for Chlorophyll De-excitation Processes through Comparison of Inverse Fluorescence Intensities. Plant Cell Physiol. 50, 1600-1616 (2009). Takahashi, H., Takahara, K., Hashida, S-N., Hirabayashi, T., Fujimori, T., Kawai-Yamada, M., Yamaya, T., Yanagisawa, S., and Uchimiya, H.: Pleiotropic modulation of carbon and nitrogen metabolism in Arabidopsis plants overexpressing NAD kinase 2 gene. Plant Physiol. 151, 100-113 (2009). Kawai-Yamada, M., Hori, Z., Ogawa, T., Ihara-Ohori, Y., Tamura, T., Nagano, M., Ishikawa, T., and Uchimiya, H.: Loss of calmodulin binding to bax inhibitor-1 affects pseudomonas mediated presensitive respose-cell death in Arabidopsis thaliana. J Biol. Chem. 284, 27998-28003 (2009). Miyagi, A., Takahashi, H., Takahara, K., Hirabayashi, T., Nishimura, Y., Tezuka, T., Kawai-Yamada, M., and Uchimiya, H.: Principal component and hierarchical clustering analysis of metabolites in destructive weeds; polygonaceous plants. Metabolomics 6, 146-155 (2010). Ishikawa, T., Takahara, K., Hirabayashi, T., Matsumura, H., Fujisawa, S., Terauchi, R., Uchimiya, H. and Kawai-Yamada, M.: Metabolome analysis of response to oxidative stress in rice suspension cells overexpressing cell death suppressor Bax inhibitor-1. Plant Cell Physiol. 51, 9-20 (2010). Takahara, K., Kasajima, I., Takahashi, H., Hashida, S. N., Itami, T., Onodera, H., Toki, S., Yanagisawa, S., Kawai-Yamada, M. and Uchimiya, H.: Metabolome and photochemical analysis of rice plants over-expressing Arabidopsis NAD kinase gene. Plant Physiol. (In press)

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Watanabe, C. K., Hachiya, T., Takahara, K., Kawai, M., Uchimiya, H., Uesono, Y., Terashima, I. and Noguchi, K.: Effects of AOX1a deficiency on plant growth, gene expression of respiratory components, and metabolic profile under low-nitrogen stress in Arabidopsis thaliana plants. Plant Cell Physiol. (in press) 「総説」 Hashida, S., Takahashi, H., and Uchimiya, H.: The role of NAD biosynthesis in plant development and stress responses. Ann. Bot. 109, 819-824 (2009). ＜細胞形態研究分野＞ 「原著論文」

Shimada, A., Takano, K., Shirouzu, M., Hanawa-Suetsugu, K., Terada, T., Toyooka, K., Umehara, T., Yamamoto, M., Yokoyama, S. and Suetsugu, S.: Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II. FEBS Lett. 584(6), 1111-8. Epub (2010). Suetsugu, S.: The direction of actin polymerization for vesicle fission suggested from membranes tubulated by the EFC/F-BAR domain protein FBP17. FEBS Lett. 583(21), 3401-4. Epub (2009). Taniguchi, K., Takeya, R., Suetsugu, S., Kan-O M, Narusawa, M., Shiose, A., Tominaga, R. and Sumimoto, H.: Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. J Biol Chem. 284(43), 29873-81. Epub (2009). 「総説」 Suetsugu, S., Toyooka, K. and Senju, Y.: Subcellular membrane curvature mediated by the BAR domain superfamily proteins. Semin Cell Dev Biol. [Epub ahead of print] (2009). ＜形態形成研究分野＞ 「原著論文」 Taniue, K., Nishida, A., Hamada, F., Sugie, A., Oda, T., Ui-Tei, K., Tabata, T. and Akiyama, T.: Sunspot, a link between Wingless signaling and endoreplication in Drosophila. Development (in press) Murakami, S., Dan, C., Zagaeski, B., Maeyama, Y., Kunes, S. and Tabata, T.: Optimizing Drosophila Olfactory Learning with a Semi-automated Training Device. Journal of Neuroscience Methods. 188, 195-204 (2010).

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Suzuki, E., Zhao Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, A., Aigaki, T., Tabata, T., Takeyama, K. and Kato, S.: Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Proc Natl Acad Sci USA, 106, 3818-3822 (2009). Zhao, Y., Takeyama, K., Sawatsubashi, S., Ito, S., Suzuki, E., Yamagata, K., Tanabe, M., Kimura, S., Fujiyama, S., Ueda, T., Murata, T., Matsukawa, H., Shirode, Y., Kouzmenko, A., Li, F., Tabata, T. and Kato, S.: Corepressive action of CBP on androgen receptor transactivation inpericentric heterochromatin in a Drosophila experimental model system. Mol. Cell. Biol. 29 (4) ,1017-1034 (2009). ＜細胞形成研究分野＞ 「原著論文」 Nakada, S., Sakakura, M., Takahashi, H., Okuda, S., Tokuda, H., and Shimada, I.: Structural investigation of the interaction between LolA and LolB using NMR. J. Biol. Chem. 284, 24634-24643 (2009). Narita, S., and Tokuda, H.: Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides. FEBS Lett. 583, 2160-2164 (2009). Tsukahara, J., Mukaiyama, K., Okuda, S., Narita, S., and Tokuda, H.: Dissection of the LolB function; lipoprotein binding, membrane targeting, and incorporation of lipoproteins into lipid bilayers. FEBS J. 276, 4496-4504 (2009). Yasuda M., Iguchi-Yokoyama A., Matsuyama S., Tokuda H., and Narita S.: Membrane topology and functional importance of the periplasmic region of ABC transporter LolCDE. Biosci. Biotechnol. Biochem. 73, 2310-2316 (2009). Tsukahara, J., Narita, S., and Tokuda, H.: Real time analysis of lipoprotein transfer from LolA to LolB by means of surface plasmon resonance. FEBS Lett. 583, 2987-2990 (2009). Nishiyama, K., and Tokuda, H.: Development of a functional in vitro integration system for an integral membrane protein, SecG. Biochem. Biophys. Res. Commun. 390, 920-924 (2009). Nishiyama, K., Maeda, M., Abe, M., Kanamori, T., Shimamoto, K., Kusumoto, S., Ueda, T., and Tokuda, H. A novel complete reconstitution system for membrane integration of the simplest membrane protein. Biochem. Biophys. Res. Commun. (Epub 2010 Mar).

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「出版物」

Narita, S., and Tokuda, H.: Sorting of bacterial lipoproteins to the outer membrane by the Lol system. In A. Economou (ed.), Protein secretion: Methods and Protocols (Methods in Molecular Biology Vol. 619) Chapter 7. Humana Press (Totowa, USA) (2010). Narita, S., and Tokuda, H.: Biogenesis and membrane targeting of lipoproteins. In A. Böck, R. Curtiss III, J. B. Kaper, P. D. Karp, F. C. Neidhardt, T. Nyström, J. M. Slauch, C. L. Squires, and D. Ussery (eds.), EcoSal—Escherichia coli and Salmonella: Cellular and Molecular Biology. Chapter 4.3.7. ASM Press (Washington, DC, USA) (2010). ＜機能形成研究分野＞ 「原著論文」 Chen, Y. R., Sekine, K., Nakamura, K., Yanai, H. Tanaka, M. and Miyajima A.: Y-box binding protein-1 down-regulates expression of carbamoyl phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha function in mice. Gastroenterology 137, 330-340 (2009).

Okabe, M., Tsukahara, Y., Tanaka, M., Suzuki, K., Saito, S., Kamiya, Y., Tsujimura, T.,

Nakamura, K., Miyajima, A.: Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse livers. Development 136, 1951-1960 (2009).

Esashi, E., Ito, H., Minehata, K., Saito, S., Morikawa, Y. and Miyajima, A.: Oncostatin M deficiency leads to thymic hypoplasia, accumulation of apoptotic thymocytes and glomerulonephritis. Eur. J. Immunol. 39, 1664-1670 (2009).

Itoh, T., Kamiya, Y., Okabe, M., Tanaka, M. and Miyajima, A.: Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response. FEBS Letters 583, 777-781 (2009).

Tomita, T., Yamada, A., Miyakoshi, M., Kido, T., Sheikh, F., Srisodsai, A., Miyajima A., Donnelly R. P. and Kimura S.: Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner. Am J Respir Cell Mol Biol. 40, 620-630 (2009).

Tanimizu, N., Miyajima, A. and Mostov K.: Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesis. Mol. Biol. Cell. 20, 2486-2494 (2009). Tanaka, M., Okabe, M., Suzuki, K., Kamiya, Y., Tsukahara, Y., Saito, S. and Miyajima A.: Mouse hepatoblasts at distinct developmental stages are characterized by expression of EpCAM and DLK1: drastic change of EpCAM expression during liver

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development. Mech. Dev. 126, 665-676 (2009). Hirose, Y., Itoh, T. and Miyajima, A. Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells. Exp. Cell Res. 315, 2648-2657 (2009).

Yamamoto, Y., Kosaka, N., Tanaka, M., Koizumi, F., Kanai, Y., Mizutani, T., Murakami, Y., Kuroda, M., Miyajima, A., Kato T. and Ochiya T.: MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma. Biomarkers 14, 529-538 (2009).

Miyaoka, Y., Tanaka, M., Imamura, T., Takada, S. and Miyajima A. A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk). Development 137, 159-167 (2010). Onitsuka, I., Tanaka, M. and Miyajima A.: Characterization and functional analyses of hepatic mesothelial cells in mouse liver development. Gastroenterology 138, 1525-1536 (2010). Yanai, H., Nakamura, K., Hijioka, S., Kamei, A., Ikari, T., Ishikawa, Y., Shinozaki, E., Mizunuma, N., Hatake, K. and Miyajima A.: Dlk-1, a cell surface antigen on fetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency. J. Biochem. in press. ＜発生分化構造研究分野＞ 「原著論文」 Sato, L., Noguchi, S., Hayashi, Y., Sakamoto, M. and Horikoshi, M.: Global analysis of functional relationships between histone point mutations and the effects of histone deacetylase inhibitors. Genes Cells, (in press). Akai, Y., Adachi, N., Hayashi, Y., Eitoku, M., Sano, N., Natsume, R., Kudo, N., Tanokura, M., Senda, T. and Horikoshi, M.: Structure of the histone chaperone CIA/ASF1–double bromodomain complex connecting histone modifications and site-specific histone eviction. Proc. Natl. Acad. Sci. U.S.A., (in press). Sakamoto, M., Noguchi, S., Kawashima, S., Okada, Y., Enomoto, T., Seki, M. and Horikoshi, M.: Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants. Genes Cells, 14, 1271-1330 (2009). Hayashi, Y., Senda, T., Sano, N. and Horikoshi, M.: Theoretical framework for the histone modification network: modifications in the unstructured histone tails form a robust scale-free network. Genes Cells, 14, 789-806 (2009).

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「出版物」 堀越正美 著：「スーパーサイエンスハイスクール講義-LET IT BE OR NOT」

培風館.(2009)

堀越正美 監訳：「エピジェネティクス」培風館.(2010) ＜生体超高分子研究分野 豊島研究室＞ 「原著論文」 Ogawa, H., Shinoda, T., Cornelius, F. and Toyoshima, C.: Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain. Proc. Nat. Acad. Sci. USA 106, 13742-13747 (2009). Tsuda, T. and Toyoshima, C.: Nucleotide recognition by CopA, a Cu+-transporting P-type ATPase. Embo J. 28, 1782-1791 (2009). Shinoda, T., Ogawa, H., Cornelius, F. and Toyoshima, C: Crystal structure of the sodium-potassium pump at 2.4 Å resolution. Nature. 459, 446-450 (2009). Ogawa, H., Qui, Y., Huang, L., Tam-Chang, S.W., Young, H.S. and Misono, K.S.: Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy. FEBS J. 276, 1347-1355 (2009). 「総説」 Toyoshima, C.: How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane. Biochem. Biophys. Acta 1793, 941-946 (2009). ＜生体超高分子研究分野 前田研究室＞ 「原著論文」 Nishizawa, M., Tanigawa, M., Hayashi, M., Maeda, T., Yazaki, Y., Saeki, Y. and Toh-e, A.: Pho85 kinase, a cyclin-dependent kinase, regulates nuclear accumulation of the Rim101 transcription factor in the stress-response of yeast. Eukaryotic Cell (in press). 「総説」 Ohne, Y., Takahara, T. and Maeda, T.: Evaluation of mTOR function by a gain-of-function approach. Cell Cycle 8, 573-579 (2009). 高原照直、前田達哉: mTOR阻害薬. 腎と透析, 67 607-613 (2009).

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＜生体有機化学研究分野＞ 「原著論文」 Uno, S., Endo, K., Jeong, Y., Kawana, K., Miyachi, H., Hashimoto, Y. and Makishima, M.: Suppression of β-catenin signaling by liver X receptor ligands. Biochem. Pharmacol. 77, 186-195 (2009). Dodo, K., Minato, T. and Hashimoto, Y.: Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate. Chem. Pharm. Bull. 57, 190-194 (2009). Aoyama, H., Sako, K., Sato, S., Nakamura, M., Miyachi, H., Baba, M. and Hashimoto, Y.: Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity. Heterocycles 77, 779-785 (2009). Noguchi-Yachide, T., Tetsuhashi, M., Aoyama, H. and Hashimoto, Y.: Enhancement of chemically-induced HL-60 cell differentiation by 3,3’-diindolylmethane derivatives. Chem. Pharm. Bull. 57, 536-540 (2009). Yokoyama, A., Makishima, M., Choi, M., Cho, Y., Nishida, S., Hashimoto, Y. and Terui, T.: Induction of SREBP-1c mRNA by differentiation and LXR ligand in human keratinocytes. J. Invest. Dermatol. 129, 1395-1401 (2009). Hosoda, S., Aoyama, H., Goto, Y., Salim, M.T., Okamoto, M., Hashimoto, M., Baba, M. and Hashimoto, Y.: Discovery of diphenylmethane analogs as anti-bovine viral diarrhea viral agents. Bioorg. Med. Chem. Lett. 19, 3157-3161 (2009). Nakamura, M., Hamasaki, T., Tokitou, M., Baba, M., Hashimoto, Y. and Aoyama, H.: Discovery of tetramethyltatrahydronaphthalene analogs as adult T-cell leukemia cells-selective proliferation inhibitors in a small chemical library constructed based on multi-template hypothesis. Bioorg. Med. Chem. 17, 4740-4746 (2009). Wakabayashi, K., Okamura, M., Tsutsumi , S., Nishikawa, N.S., Tanaka, T., Sakakibara, I., Kitakami, J., Ihara, S., Hashimoto, Y., Hamakubo, T., Kodama, T., Aburatani, H. and Sakai, J.: The peroxisome proliferator-activated receptor γ/retinoid X receptor α heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol. Cell. Biol. 29, 3544-3555 (2009). Hosoda, S., Matsuda, D., Tomoda, H., Hashimoto, M., Aoyama, H. and Hashimoto, Y.: Application of a 3,3-diphenylpentane skeleon as a multi-template for creation of HMG-CoA reductase inhibitors. Bioorg. Med. Chem. Lett. 19, 4228-4231 (2009). Motoshima, K., Noguchi-Yachide, T., Sugita, K., Hashimoto Y. and Ishikawa, M.: Separation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of

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phenethylphenylphthalimide analogs and generation of LXRα-selective antagonists. Bioorg. Med. Chem. 17, 5001-5014 (2009). Oyama, T., Toyota, K., Waku, T., Hirakawa, Y., Nagasawa, N., Kasuga, J., Hashimoto, Y., Miyachi H. and Morikawa, K.: Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures. Acta Crystallographica (D) D65, 786-795 (2009). Aoyama, A., Aoyama, H., Makishima, M., Hashimoto Y. and Miyachi. H.: Liver X receptor (LXR) modulators with dibenz[b,f][1,4]oxazepin-11-one, (Z)-dibenz[b,f]azocin- 6-one, and 11,12-dihydrodibenz[b,f]azocin-6-one skeleton. Heterocycles 78, 2209-2216 (2009). Motoshima, K., Ishikawa, M., Sugita, K. and Hashimoto, Y.: Glycogen phosphorylase a inhibitors with a phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidsase inhibitors and liver X receptor antagonists. Biol. Pharm. Bull. 32, 1618-1620 (2009). Kasuga, J., Ishida, S., Yamasaki, D., Makishima, M., Doi, T., Hashimoto, Y. and Miyachi, H.: Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ selective antagonists. Bioorg. Med. Chem. Lett. 19, 6595-6599 (2009). Wang, W., Lee, J.-S., Nakazawa, T., Ukai, K., Mangindaan, R.E., Wewengkang, D.S., Rotinsulu, H., Kobayashi, H., Tsukamoto, S. and Namikoshi, M.: (25S)-Cholesten-26-oic acid derivatives from an Indonesian soft coral Minabea sp. Steroids 74, 758-760 (2009). Wang, W., Takahashi, O., Oda, T., Nakazawa, T., Ukai, K., Mangindaan, R.E., Rotinsulu, H., Wewengkang, D.S., Kobayashi, H., Tsukamoto, S. and Namikoshi, M.: Lissoclibadins 814, polysulfur dopamine-derived alkaloids from the colonial ascidian Lissoclinum cf. badium. Tetrahedron 65, 9598-9603 (2009). Noguchi-Yachide, T., Dodo, K., Aoyama, H., Fujimoto, H., Hori, M., Hashimoto, Y. and Kobayashi, H.: Identification of binding proteins of fusarielin A as actin and tubulin. Chem. Pharm. Bull. 58, 129-134 (2010). Fujita, Y., Yonehara, M., Tetsuhashi, M., Noguchi-Yachide, T., Hashimoto Y. and Ishikawa, M.: β-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: improvement of solubility by disruption of molecular planarity. Bioorg. Med. Chem. 18, 1194-1203 (2010).

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Mita, Y., Dodo, K., Noguchi-Yachide, T., Miyachi, H., Makishima, M., Hashimoto, Y. and Ishikawa, M.: LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators. Bioorg. Med. Chem. Lett. 20, 1712-1717 (2010). Nakamura, M., Aoyama, A., Salim, M.T., Okamoto, M., Baba, M. Miyachi, H., Hashimoto, Y.and Aoyama H.: Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton. Bioorg. Med. Chem. 18, 2402-2411 (2010). 「総説」 橋本祐一：マルチテンプレート手法によるサリドマイドの構造展開と活性拡張．

和光純薬時報 77, 2-5 (2009). Hosoda, S., Matsuda, D., Tomoda, H. and Hashimoto, Y.: Dipheynylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes. Mini-Rev. Med. Chem. 9, 572-580 (2009). 宮地弘幸、青山惇、橋本祐一：配座固定を基盤とした核内受容体 LXR の新規リガンド創製 MEDCHEM NEWS 19, 30-37 (2009). 春日淳一、大山拓次、中込泉、青山惇、迫久美子、槙島誠、広野修一、森川耿

右、橋本祐一、宮地弘幸：PPARδ選択的アゴニストの創製と受容体-リガンド複合体構造情報を踏まえた選択性発現機構解明 薬学雑誌 129, 709-718 (2009). 「出版物」 Hashimoto, Y.: Interaction of biological response modifier with proteins. Chapter 8 in “Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications”, ed. By Osada, Y., p149-168, John Wiley & Sons, Inc., New Jersey, ISBN: 978-0-470-12053-8 (2009). ＜RNA 構造研究分野＞ 「原著論文」

Yoda, M., Kawamata, T., Paroo, Z., Ye, X., Iwasaki, S., Liu, Q. and Tomari, Y.: ATP-dependent human RISC assembly pathways. Nat Struct Mol Biol. Epub (2009). Kawamata, T., Seitz, H. and Tomari, Y.: Structural requirement of miRNAs for RISC-loading and slicer-independent unwinding. Nat Struct Mol Biol. 16 953-960 (2009). Kawaoka, S., Hayashi, N., Suzuki, Y., Abe, H., Sugano, S., Tomari, Y., Shimada,T. and Katsuma, S.: The Bombyx ovary-derived cell line endogenously expresses PIWI/PIWI-interacting RNA complexes. RNA. 15, 1258-1264 (2009).

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Iwasaki, S., Kawamata, T. and Tomari, Y.: Drosophila Argonaute1 and Argonaute2 employ distinct mechanisms for translational repression. Mol Cell. 34, 58-67 (2009). 「総説」 塩濱愛子, 泊幸秀. RNAサイレンシング. 遺伝子医学MOOK, 15 メディカルドゥ 34-41 (2009). Iwasaki, S. and Tomari, Y.: Argonaute-mediated translational repression (and activation).Fly (Austin). 14 (2009). ＜創生研究分野＞ 「原著論文」 Sakuraba, S. and Kitao, A.: Multiple Markov transition matrix method: Obtaining the stationary probability distribution from multiple simulations. J. Comp. Chem. 30, 1850-1858 (2009). Loeffler, H. H. and Kitao, A.: Collective Dynamics of Periplasmic Glutamine Binding Protein upon Domain Closure. Biophys. J. 97, 2541-2549 (2009). Chng, C. P. and Kitao, A.: Mechanical unfolding of bacterial flagellar filament protein by molecular dynamics simulation. J. Mol. Graph. Model 28, 548-554 (2010). ＜高次構造研究分野＞ 「原著論文」

Inagaki, H. K., Kamikouchi, A., and Ito, K.: Methods for quantifying simple gravity sensing in Drosophila melanogaster. Nat Protoc 5, 20-25, (2010). Inagaki, H. K., Kamikouchi, A., and Ito, K.: Protocol for quantifying sound-sensing ability of Drosophila melanogaster. Nat Protoc 5, 26-30, (2010). Schnell, B., Joesch, M., Foerstner, F., Raghu, S. V., Otsuna, H., Ito, K., Borst, A., and Reiff, D. F.: Processing of horizontal optic flow in three visual interneurons of the Drosophila Brain. J Neurophysiol, 103, 1646-57, (2010). Okada, R., Awasaki, T. and Ito, K.: GABA-mediated neural connections in the Drosophila antennal lobe. J Comp Neurol, 514, 74-91, (2009). Tanaka, N. K., Ito, K. and Stopfer, M.: Odor-evoked neural oscillations in Drosophila are mediated by widely branching interneurons. J Neurosci, 29, 8595-603, (2009).

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Busch, S., Selcho, M., Ito, K. and Tanimoto, H.: A map of octopaminergic neurons in the Drosophila brain and subesophageal ganglion. J Comp Neurol, 513, 643-667, (2009). Sakurai, M., Aoki, T., Yoshikawa, S., Santschi, L. A., Saito, H., Endo, K., Ishikawa, K., Kimura, K., Ito, K., Thomas, J. B., and Hama, C. Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development. J Neurosci 29, 4972-4980, (2009). ＜バイオリソーシス研究分野＞ 「原著論文」 Khamna, S., Yokota, A. and Lumyong, S.: Actinomycetes isolated from medicinal plant rhizosphere soils: diversity and screening of antifungal compounds, indole-3-acetic acid and siderophore production. World J. Microbiol. Biotechnol. 25, 649-655 (2009). Khamna, S., Yokota, A. and Lumyong, S.: L-Asparaginase production by actinomycetes isolated from some Thai medicinal plant rhizosphere soils. Int. J. Integr. Biol. 6, 22-26 (2009). Miwa, H., Ahmed, I., Yokota, A. and Fujiwara, T.: Lysinibacillus parviboronicapiens sp. nov., aerobic spore-forming bacterium isolated from soil. Int. J. Syst. Evol. Microbiol. 59, 1427-1432 (2009). Yoshizawa, S., Wada, M., Kita-Tsukamoto, K., Yokota, A. and Kogure, K.: Photobacterium aquimaris sp. nov., luminous marine bacteria isolated from sea water. Int. J. Syst. Evol. Microbiol. 59, 1438-1442 (2009). Tominaga, T., An, S.-Y., Oyaizu, H. and Yokota, A.: Sporosarcina lutea sp. nov., isolated from soy sauce production equipment in Japan. J. Gen. Appl. Microbiol. 55, 217-223 (2009). Tominaga, T., An, S.-Y., Oyaizu, H. and Yokota, A.: Oceanobacilllus soja sp. nov., isolated from soy sauce production equipment in Japan. J. Gen. Appl. Microbiol. 55, 225-232 (2009). Yoshizawa, S., Wada, M., Kita-Tsukamoto, K., Yokota, A. and Kogure, K.: Vibrio azureus sp. nov., luminous marine bacteria isolated from sea water. Int. J. Syst. Evol. Microbiol. 59, 1645-1649 (2009). Fukunaga, Y., Kurahashi, M., Sakiyama, Y., Ohuchi, M., Yokota, A. and Harayama, S.: Phycisphaera mikurensis gen. nov., sp. nov., isolated from a marine alga, and proposal

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of Phycisphaeraceae fam. nov., Phycisphaerales ord. nov. and Phycisphaerae classis nov. in the phylum Planctomycetes. J. Gen. Appl. Microbiol. 55, 267-275 (2009). Yabe, S., Kato, A., Hazaka, M. and Yokota, A.: Thermaerobacter composti sp. nov., a novel extremely thermophilic bacterium isolated from compost. J. Gen. Appl. Microbiol. 55, 323-328 (2009). An, S.-Y., Xio, T. and Yokota, A.: Leifsonia lichenia sp. nov., isolated from lichen in Japan. J. Gen. Appl. Microbiol. 55, 339-343 (2009). Khamna, S., Yokota, A., Peberdy, J. F. and Lumyong, S.: Antifungal activity of Streptomyces sp. isolated from Thai medicinal plant rhizosphere soils. Int. J. Integr. Biol. 6, 143-147 (2009). Bautista, V. V., Monsalud, R. and Yokota, A.: Devosia yakushimensis sp. nov., isolated from root nodules Pueraria lobata (Willd.) Ohwi. Int. J. Syst. Evol. Microbiol. 60, 627-632 (2010). Yabe, S., Aiba, Y., Sakai, Y., Hazaka, M. and Yokota, A.: Thermosporothrix hazakensis gen. nov., sp. nov., isolated from compost and description of Thermosporotrichaceae fam. nov. within the class Ktedonobacteria. Int. J. Syst. Evol. Microbiol. 60, doi: 10.1099/ijs.0.018069-0 (2010). Kurahashi, M., Fukunaga, Y., Sakiyama, Y., Harayama S. and Yokota, A.: Euzebya tangerina gen. nov., sp. nov., a deeply branching marine actinobacterium isolated from sea cucumber Holothuria edulis and proposal of Euzebyaceae fam. nov., Euzebyales ord. nov. and Nitriliruptoridae subclassis nov. Int. J. Syst. Evol. Microbiol. 60, doi: 10.1099/ijs.0.016543-0 (2010) Yoon, J., Miwa, H., Ahmed, I., Yokota, A. and Fujiwara, T.: Rhodococcus baikonurensis BTM4c, a boron-tolerant actinobacterial strain isolated from soil. Biosci. Biotechnol. Biochem. 74, 178-181 (2010). An, S.-Y., Xiao, T. and Yokota, A.: Reclassification of Leifsonia aurea to the genus Rhodoglobus as Rhodoglobus aureus comb. nov., and emended description of Rhodoglobus vestalii Sheridan et al. J. Gen. Appl. Microbiol. 56, 53-55 (2010). Khamna, S., Yokota, A., Peberdy, J. F. and Lumyong, S.: Indol-3-acetic acid production by Streptomyces sp. isolated from some Thai medicinal plant rhizosphere soils. EurAsian J. Biosci. 4, 23-32 (2010).

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＜放射線連携研究機構＞ 「原著論文」 Yamashita, M., Kurokawa, K., Sato, Y., Yamagata, A., Mimura, H., Yoshikawa, A., Sato, K., Nakano, A. and Fukai, S.: Structural basis for the Rho- and phosphoinositide-dependent localization of the exocyst subunit Sec3. Nature Struct. Mol. Biol. 17, 180-186 (2010). Yamagata, A., Mimura, H., Sato, Y., Yamashita, M., Yoshikawa, A. and Fukai, S.: Structural insight into the membrane insertion of tail-anchored proteins by Get3. Genes Cells 15, 29-41 (2010). Sato, Y., Yoshikawa, A., Yamashita, M., Yamagata, A. and Fukai, S.: Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3. EMBO J. 28, 3903-3909 (2009). Yoshikawa, A., Sato, Y., Mimura, H., Yamashita, M., Yamagata, A. and Fukai, S.: Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin. FEBS Lett. 583, 3317-3322 (2009). Toh, Y., Takeshita, D., Numata, T., Fukai, S., Nureki, O. and Tomita, K.: Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme. EMBO J. 28, 3353-3365 (2009). Sato, Y., Yoshikawa, A., Mimura, H., Yamashita, M., Yamagata, A. and Fukai, S.: Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80. EMBO J. 28, 2461-2468 (2009). Shirakawa, R., Fukai, S., Kawato, M., Higashi, T., Kondo, H., Ikeda, T., Nakayama, E., Okawa, K., Nureki, O., Kimura, T., Kita, T. and Horiuchi, H.: Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. J. Biol. Chem. 284, 21580-21588 (2009). 「総説」 深井 周也「K63結合型選択的な脱ユビキチン化機構」生化学，81巻，815-819 (2009) 佐藤 裕介，深井 周也「Lys63 結合型ポリユビキチン鎖の選択的切断メカニズム」生体の科学，60巻 (2009) 佐藤 裕介，深井 周也「ユビキチン鎖の認識と選択的切断メカニズムの構造

的理解」日本結晶学会誌，52巻 (2010)