© 2006 plataforma bioinformàtica de la uab recerca biològica a la web 1. bases de dades de...
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© 2006 Plataforma Bioinformàtica de la UAB
Recerca biològica a la WebRecerca biològica a la Web
1. Bases de dades de bibliografia científica
Cursd’introducció a la bioinformàticaCursd’introducció a la bioinformàticaPlataforma Bioinformàtica de la UAB
© 2006 Plataforma Bioinformàtica de la UAB
L’art de trobar informació a la WebL’art de trobar informació a la Web
• Internet és una font d’informació tremendament útil per a la recerca biològica
• ... però el Google em dóna milions d’entrades a les meves cerques, i la que jo vull és la número 342...!
• On puc anar a trobar la informació que necessito?
• Com put jutjar quina informació és fiable?
© 2006 Plataforma Bioinformàtica de la UAB
Bases de dades bibliogràfiquesBases de dades bibliogràfiques
Organització dels articles publicats a les revistes d’àmbit científic.
– Medline
– Pubmed (NCBI)
© 2006 Plataforma Bioinformàtica de la UAB
Operadors lògics o booleansOperadors lògics o booleans
• AND / + keyword1 i keyword2» human AND mouse
• OR / ^ keyword1 o keyword2» human OR mouse
• NOT / - keyword1 però no keyword2» mammal NOT human
• ? / * mots parcials (inici / final)» ?ribonucleotide deoxy*
• “” frases» “major histocompatibility complex”
• (...) estructures complexes» (mhc AND mammal) NOT human
© 2006 Plataforma Bioinformàtica de la UAB
Entrez PubMed Search fieldsEntrez PubMed Search fields
• Exemple: Lander+ES[AU] = “Lander ES”[AU]
© 2006 Plataforma Bioinformàtica de la UAB
Exercici bàsicExercici bàsic
• Find citations to articles about female
genital diseases published in 2006 by
Edward W. Cowen or Giovanni Parmigiani. female genital diseases AND 2006[DP] AND
("Cowen EW"[AU] OR "Parmigiani G"[AU])
© 2006 Plataforma Bioinformàtica de la UAB
Medical Subject Headings (MeSH)Medical Subject Headings (MeSH)
• Vocabulari controlat de mots mèdics• Estructura jeràrquica• Garantitza una correcta indexació dels
documents del MEDLINE / PubMed
• http://www.nlm.nih.gov/mesh/meshhome.html
1. Cerques 2. Combinació de mots 3. Altres característiques
© 2006 Plataforma Bioinformàtica de la UAB
Exercici avançatExercici avançat
• Find citations to articles about female
genital diseases in adolescents and health
education methods and trends used to
educate this group. Limit the results to
citations published in English since 1990.
© 2006 Plataforma Bioinformàtica de la UAB
Exercici avançatExercici avançat
Step 1: Click on Preview/Index.
Find citations to articles about female genital diseases in adolescents and health
education methods and trends used to educate this group. Limit the results to
citations published in English since 1990.
© 2006 Plataforma Bioinformàtica de la UAB
Exercici avançatExercici avançat
Step 2: Go to the "Add Term(s) to Query or View Index" section of the screen and use the All Fields pull-down to select the MeSH Terms search field.
Find citations to articles about female genital diseases in adolescents and health
education methods and trends used to educate this group. Limit the results to
citations published in English since 1990.
© 2006 Plataforma Bioinformàtica de la UAB
Exercici avançatExercici avançat
Step 3: Enter your first term (female genital diseases) in the text box. Click Preview. PubMed adds the term to the query box and previews the number of search results.
Find citations to articles about female genital diseases in adolescents and health
education methods and trends used to educate this group. Limit the results to
citations published in English since 1990.
© 2006 Plataforma Bioinformàtica de la UAB
Exercici avançatExercici avançat
Step 4: Return to the "Add Term(s) to Query or View Index" section of the screen. Notice that the search field is set to MeSH Terms. Enter your next term (adolescents) in the text box. Click Preview. PubMed adds the term to the query box with an AND operator and previews the number of search results (i.e., female genital diseases AND adolescents).
Find citations to articles about female genital diseases in adolescents and health
education methods and trends used to educate this group. Limit the results to
citations published in English since 1990.
© 2006 Plataforma Bioinformàtica de la UAB
Exercici avançatExercici avançat
Step 5: Return to the "Add Term(s) to Query or View Index" section of the screen. Notice that the search field is still set to MeSH Terms. Enter your next term (health education) in the text box. This time, click Index. PubMed displays the MeSH Terms Index beginning with the term health education.
Find citations to articles about female genital diseases in adolescents and health
education methods and trends used to educate this group. Limit the results to
citations published in English since 1990.
© 2006 Plataforma Bioinformàtica de la UAB
Exercici avançatExercici avançat
Step 6: Select the terms health education/methods and health education/trends by holding down the Ctrl key and clicking on the terms. Click Preview. PubMed automatically ORs the selected terms together, ANDs them to the query, and previews the number of search results.
Find citations to articles about female genital diseases in adolescents and health
education methods and trends used to educate this group. Limit the results to
citations published in English since 1990.
© 2006 Plataforma Bioinformàtica de la UAB
Exercici avançatExercici avançat
Step 7: Click on Limits. Use the Published in the Last date, and select Specify Date Range to choose articles published from 1990 to present (i.e., From: 1990). Use the Language menu to select English. Click Go.
Find citations to articles about female genital diseases in adolescents and health
education methods and trends used to educate this group. Limit the results to
citations published in English since 1990.
© 2006 Plataforma Bioinformàtica de la UAB
Exercici avançatExercici avançat
Find citations to articles about female genital diseases in adolescents and health
education methods and trends used to educate this group. Limit the results to
citations published in English since 1990.
© 2006 Plataforma Bioinformàtica de la UAB
Altres motors de cerca bibliogràficaAltres motors de cerca bibliogràfica
© 2006 Plataforma Bioinformàtica de la UAB
Revistes científiquesRevistes científiques